Reviewed, UniProtKB/Swiss-Prot Q2RBK2 (LAC17_ORYSJ)

Names and origin

Protein names

Recommended name:
    Putative laccase-17
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 17
    Urishiol oxidase 17
    Diphenol oxidase 17

Gene names

Name:	LAC17
Ordered Locus Names:	Os11g0108700, LOC_Os11g01730
ORF Names:	OsJ_031367

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Lignin degradation and detoxification of lignin-derived products By similarity.
Catalytic activity	4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.
Cofactor	Binds 4 copper ions per monomer By similarity.
Subcellular location	Secreted › extracellular space › apoplast Potential.
Sequence similarities	Belongs to the multicopper oxidase family. Contains 3 plastocyanin-like domains.

Ontologies

Keywords
Biological process	Lignin degradation
Cellular component	Apoplast Secreted
Domain	Repeat Signal
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	apoplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW laccase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 567	545	Putative laccase-17		PRO_0000291901
Regions
	Domain	30 – 146	117	Plastocyanin-like 1
	Domain	158 – 310	153	Plastocyanin-like 2
	Domain	415 – 551	137	Plastocyanin-like 3
Sites
	Metal binding	80	1	Copper 1 By similarity
	Metal binding	82	1	Copper 2 By similarity
	Metal binding	125	1	Copper 2 By similarity
	Metal binding	127	1	Copper 3 By similarity
	Metal binding	468	1	Copper 4 By similarity
	Metal binding	471	1	Copper 1 By similarity
	Metal binding	473	1	Copper 3 By similarity
	Metal binding	530	1	Copper 3 By similarity
	Metal binding	531	1	Copper 4 By similarity
	Metal binding	532	1	Copper 2 By similarity
	Metal binding	536	1	Copper 4 By similarity
Amino acid modifications
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	241	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Glycosylation	365	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Glycosylation	378	1	N-linked (GlcNAc...) Potential
	Glycosylation	388	1	N-linked (GlcNAc...) Potential
	Glycosylation	430	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2RBK2-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: AD2816C44ED952B5	FASTA	567	61,544
	10 20 30 40 50 60 MPSRGCSCWL LSLALLCSLA AAKEQYHEFV IRETTVKRLC KSHNIMTVNG QFPGPTLEIN 70 80 90 100 110 120 EGDSLIINLI NRGRYNMTLH WHGVRQMRTG WSDGPEYVTQ CPVRPGQSYR YRFTVAAQEG 130 140 150 160 170 180 TLWWHAHSSW LRATVYGALL IRPRDGTSYP FDVQPTRELA PILLGEWWDM NPVDVVRAAT 190 200 210 220 230 240 RTGAAPNISD ALTVNAQPGD LYSCSSHDTA VFPVTSGETN LLRFINAALN TELFVSLAGH 250 260 270 280 290 300 NMTVVAADAS YTKPYTTSLL LLAPGQTTDV LVTFDQPPGR YYLAARAYAS AQGVPFDNTT 310 320 330 340 350 360 TTAIFDYGAA NNASSAAIAM PTLPAYNDTT AATAFTTNLR GLRKAELPSR VDESLFFTVG 370 380 390 400 410 420 VGLFNCTNAT AQQCGGPNGT RFAASINNVS FVLPSSTSIL QAHHHGAPGG VFTADFPANP 430 440 450 460 470 480 PVQFDYTAQN VSRALWQPVA GTKVYKLKYG SAVQVVLQGT NIFAGENHPI HLHGYDFYIL 490 500 510 520 530 540 AEGLGNFDAG ADTGKFNVED PPMRNTVGVP VNGWAVIRFV ADNPGVWLMH CHLDVHITWG 550 560 LAMAFLVDDG VGELQSLEAP PPDLPLC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications." The rice chromosomes 11 and 12 sequencing consortia BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000010 Genomic DNA. Translation: ABA91124.1. AP008217 Genomic DNA. Translation: BAF27393.1. CM000148 Genomic DNA. Translation: EAZ17158.1.
RefSeq	NP_001065548.1.
UniGene	Os.56166
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4349566.
GenomeReviews	Gene locus LAC17 in contig AP008217_GR.
KEGG	osa:4349566.
Organism-specific databases
Gramene	Q2RBK2.
Phylogenomic databases
HOGENOM	HBG749556.
PhylomeDB	Q2RBK2.
Family and domain databases
InterPro	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR017761. Laccase. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 3 hits.
Pfam	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR03389. laccase. 1 hit.
PROSITE	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LAC17_ORYSJ

Accession

Primary (citable) accession number: Q2RBK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	January 24, 2006
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)