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Q2RAS0 (ACA5_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable calcium-transporting ATPase 5, plasma membrane-type
EC=3.6.3.8
Alternative name(s):
Ca(2+)-ATPase isoform 5
Gene names
Ordered Locus Names:Os11g0140400, LOC_Os11g04460
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length1017 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles By similarity.

Catalytic activity

ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2].

Enzyme regulation

Activated by calmodulin By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Domain

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10171017Probable calcium-transporting ATPase 5, plasma membrane-type
PRO_0000247304

Regions

Topological domain1 – 153153Cytoplasmic Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane177 – 19721Helical; Potential
Topological domain198 – 22831Cytoplasmic Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane331 – 35121Helical; Potential
Topological domain352 – 38433Cytoplasmic Potential
Transmembrane385 – 40521Helical; Potential
Transmembrane803 – 82321Helical; Potential
Topological domain824 – 8252Cytoplasmic Potential
Transmembrane826 – 84621Helical; Potential
Transmembrane875 – 89521Helical; Potential
Topological domain896 – 93843Cytoplasmic Potential
Transmembrane939 – 95921Helical; Potential
Transmembrane973 – 99321Helical; Potential
Topological domain994 – 101724Cytoplasmic Potential

Sites

Active site43414-aspartylphosphate intermediate By similarity
Metal binding7361Magnesium By similarity
Metal binding7401Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2RAS0 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 65910150C99609D8

FASTA1,017111,286
        10         20         30         40         50         60 
MEKLDRYLQE HFDVPAKNPS EEAQRRWRQA VGTIVKNRRR RFRWVPDLDR RSLDKAKVRS 

        70         80         90        100        110        120 
TQEKIRVALY VQQAALIFSD DELALITSKH DSKALKMHGG VDGISKKVRS SFDHGICASD 

       130        140        150        160        170        180 
LDTRQNIYGV NRYAEKPSRS FWMFVWDAFQ DMTLIILMVC ALLSVAVGLA TEGWPKGMYD 

       190        200        210        220        230        240 
GLGIILSIFL VVMVTAVSDY KQSLQFKELD NEKKKIFIHV TRDGRRQKIS IYDLVVGDIV 

       250        260        270        280        290        300 
HLSIGDQVPA DGLYIHGYSL LIDESSLSGE SDPVYVSQDK PFILAGTKVQ DGSAKMIVTA 

       310        320        330        340        350        360 
VGMRTEWGKL MSTLSEGGED ETPLQVKLNG VATVIGKIGL VFAILTFLVL LVRFLIDKGM 

       370        380        390        400        410        420 
TVGLLKWYST DALTIVNYFA TAVTIIVVAV PEGLPLAVTL SLAFAMKKLM NDKALVRHLS 

       430        440        450        460        470        480 
ACETMGSAGT ICTDKTGTLT TNYMVVDKIW ISEVSKSVTS NTISGELNSV VSSRTLSLLL 

       490        500        510        520        530        540 
QGIFENTSAE VVKEKDGKQT VLGTPTERAI LEFGLGLEGV HDAEYSACTK VKVEPFNSVK 

       550        560        570        580        590        600 
KKMAVLISLP SGTSRWFCKG ASEIILQMCD MMVDGDGNAI PLSEAQRKNI LDTINSFASD 

       610        620        630        640        650        660 
ALRTLCLAYK EVDDDIDDNA DSPTSGFTLI AIFGIKDPVR PGVKDAVKTC MSAGITVRMV 

       670        680        690        700        710        720 
TGDNINTAKA IAKECGILTE DGVAIEGPEF HSKSPEEMRD LIPNIQVMAR SLPLDKHTLV 

       730        740        750        760        770        780 
TNLRGMFDEV VSVTGDGTND APALHEADIG LAMGIAGTEV AKESADVIVL DDNFTTIINV 

       790        800        810        820        830        840 
ARWGRAVYIN IQKFVQFQLT VNIVALVINF VSACITGSAP LTAVQLLWVN MIMDTLGALA 

       850        860        870        880        890        900 
LATEPPNDEM MKRPPVRKGE SFITKVMWRN IMGQSLYQLF VLGALMFGGE SLLNIKGADS 

       910        920        930        940        950        960 
KSIINTLIFN SFVFCQVFNE INSREMQKIN VFRGIISNWI FIAVIAATVA FQVVIIEFLG 

       970        980        990       1000       1010 
TFASTVPLNW QHWLLSVGLG SISLIVGVIL KCIPVGSGET SATPNGYRPL ANGPDDI

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References

[1]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DP000010 Genomic DNA. Translation: ABA91401.1.

3D structure databases

ProteinModelPortalQ2RAS0.
ModBaseSearch...

Proteomic databases

PRIDEQ2RAS0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os11g04460.1; LOC_Os11g04460.1; LOC_Os11g04460.

Organism-specific databases

GrameneQ2RAS0.

Phylogenomic databases

GeneTreeEPGT00050000008540.
OMANITANTH.
PhylomeDBQ2RAS0.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006408. ATPase_P-typ_Ca-transp_PMCA.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR024750. Ca_ATPase_N_dom.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
PfamPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACA5_ORYSJ
AccessionPrimary (citable) accession number: Q2RAS0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 24, 2006
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

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