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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH1
Synonyms:DUPR11.3
Ordered Locus Names:Os11g0210300, LOC_Os11g10480
ORF Names:OsJ_032001
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607071 – 379Alcohol dehydrogenase 1Add BLAST379

Proteomic databases

PaxDbiQ2R8Z5.

Expressioni

Gene expression databases

ExpressionAtlasiQ2R8Z5. baseline and differential.
GenevisibleiQ2R8Z5. OS.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os11g10480.1.

Structurei

3D structure databases

ProteinModelPortaliQ2R8Z5.
SMRiQ2R8Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
InParanoidiQ2R8Z5.
KOiK18857.
OMAiNPQGTLQ.
OrthoDBiEOG09360BVQ.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q2R8Z5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAAK PLVIEEVEVA PPQAMEVRVK ILFTSLCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK
110 120 130 140 150
ECAHCKSAES NMCDLLRINT DRGVMIGDGK SRFSINGKPI YHFVGTSTFS
160 170 180 190 200
EYTVMHVGCV AKINPAAPLD KVCVLSCGIS TGLGATINVA KPPKGSTVAI
210 220 230 240 250
FGLGAVGLAA AEGARIAGAS RIIGIDLNAN RFEEARKFGC TEFVNPKDHD
260 270 280 290 300
KPVQQVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK
310 320 330 340 350
DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT
360 370
HSVPFSEINT AFDLMHKGEG IRCIIRMEN
Length:379
Mass (Da):40,984
Last modified:July 11, 2006 - v2
Checksum:i1281E87F3DB30545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172282 Genomic DNA. Translation: AAF34414.1.
EF122490 mRNA. Translation: ABL74577.1.
DP000010 Genomic DNA. Translation: ABA92029.2.
DP000010 Genomic DNA. Translation: ABA92030.1.
DP000010 Genomic DNA. Translation: ABA92031.2.
AP008217 Genomic DNA. Translation: BAF27847.1.
AP014967 Genomic DNA. Translation: BAT13173.1.
CM000148 Genomic DNA. Translation: EAZ17792.1.
AK069330 mRNA. No translation available.
RefSeqiXP_015616853.1. XM_015761367.1. [Q2R8Z5-1]
UniGeneiOs.21601.
Os.57564.

Genome annotation databases

EnsemblPlantsiOS11T0210300-01; OS11T0210300-01; OS11G0210300. [Q2R8Z5-1]
GeneIDi4350053.
GrameneiOS11T0210300-01; OS11T0210300-01; OS11G0210300.
KEGGiosa:4350053.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADH1_ORYSJ
AccessioniPrimary (citable) accession number: Q2R8Z5
Secondary accession number(s): P20306
, Q2R8Z6, Q2R8Z7, Q9LLP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 11, 2006
Last modified: October 25, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families