Reviewed, UniProtKB/Swiss-Prot Q2R8Z5 (ADH1_ORYSJ)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:	ADH1
Synonyms:	DUPR11.3
Ordered Locus Names:	Os11g0210300, LOC_Os11g10480
ORF Names:	OsJ_032001

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q2R8Z5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Alcohol dehydrogenase 1		PRO_0000160707
Regions
	Nucleotide binding	202 – 207	6	NAD By similarity
	Nucleotide binding	295 – 297	3	NAD By similarity
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	69	1	Zinc 1; catalytic By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	102	1	Zinc 2 By similarity
	Metal binding	105	1	Zinc 2 By similarity
	Metal binding	113	1	Zinc 2 By similarity
	Metal binding	177	1	Zinc 1; catalytic By similarity
	Binding site	226	1	NAD By similarity
	Binding site	231	1	NAD By similarity
	Binding site	372	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 11, 2006. Version 2. Checksum: 1281E87F3DB30545	FASTA	379	40,984
	10 20 30 40 50 60 MATAGKVIKC KAAVAWEAAK PLVIEEVEVA PPQAMEVRVK ILFTSLCHTD VYFWEAKGQT 70 80 90 100 110 120 PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK ECAHCKSAES NMCDLLRINT 130 140 150 160 170 180 DRGVMIGDGK SRFSINGKPI YHFVGTSTFS EYTVMHVGCV AKINPAAPLD KVCVLSCGIS 190 200 210 220 230 240 TGLGATINVA KPPKGSTVAI FGLGAVGLAA AEGARIAGAS RIIGIDLNAN RFEEARKFGC 250 260 270 280 290 300 TEFVNPKDHD KPVQQVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK 310 320 330 340 350 360 DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT HSVPFSEINT 370 AFDLMHKGEG IRCIIRMEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequence of 340 kb of DNA around the rice Adh1-Adh2 region reveals interrupted colinearity with maize chromosome 4." Tarchini R., Biddle P., Wineland R., Tingey S., Rafalski A. Plant Cell 12:381-391(2000) [PubMed: 10715324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning of alcohol dehydrogenase 1 genes in rice seeds." Yoon U.H., Kim Y.H. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: cv. Ilpoombyeo. Tissue: Seed.
[3]	"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications." The rice chromosomes 11 and 12 sequencing consortia BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[5]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[6]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[7]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF172282 Genomic DNA. Translation: AAF34414.1. EF122490 mRNA. Translation: ABL74577.1. DP000010 Genomic DNA. Translation: ABA92029.2. DP000010 Genomic DNA. Translation: ABA92030.1. DP000010 Genomic DNA. Translation: ABA92031.2. AP008217 Genomic DNA. Translation: BAF27847.1. CM000148 Genomic DNA. Translation: EAZ17792.1. AK069330 mRNA. No translation available.
RefSeq	NP_001067484.1.
UniGene	Os.21601
3D structure databases
SMR	Q2R8Z5. Positions 4-377.
ModBase	Search...
Genome annotation databases
GeneID	4350053.
GenomeReviews	Gene locus ADH1 in contig AP008217_GR.
KEGG	osa:4350053.
Organism-specific databases
Gramene	P20306.
Phylogenomic databases
HOGENOM	HBG753318.
PhylomeDB	Q2R8Z5.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_ORYSJ

Accession

Primary (citable) accession number: Q2R8Z5
Secondary accession number(s): P20306 , Q2R8Z6, Q2R8Z7, Q9LLP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	July 11, 2006
Last modified:	January 19, 2010
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)