Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2R3K3

- LCB2A_ORYSJ

UniProt

Q2R3K3 - LCB2A_ORYSJ

Protein

Long chain base biosynthesis protein 2a

Gene

Os11g0516000

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1 constitutes the catalytic core By similarity.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. photomorphogenesis Source: EnsemblPlants/Gramene
    2. pollen development Source: EnsemblPlants/Gramene
    3. regulation of programmed cell death Source: EnsemblPlants/Gramene
    4. sphingosine biosynthetic process Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_220105. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long chain base biosynthesis protein 2a (EC:2.3.1.50)
    Gene namesi
    Ordered Locus Names:Os11g0516000, LOC_Os11g31640
    ORF Names:OsJ_34042
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 11

    Organism-specific databases

    GrameneiQ2R3K3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. vacuole Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Long chain base biosynthesis protein 2aPRO_0000419150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei311 – 3111N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Heterodimer with LCB1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2R3K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    KOiK00654.
    OMAiPEPGGCC.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2R3K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRLPYTTAL TTLFSYGLLF AFGQLRDFFR KLIDWFKAKN VKGYAPICLG    50
    LEDFYVRRLY LRIQDCFGRP IASAPDAWFD VVERYSNDSN KTLKRTSNTT 100
    RCLNLGSYNY LGFAAADEYC TPLVIESLKK YSPSTCSVRV DGGTTKLHTE 150
    LEELVARFVG KPAAILFGMG YVTNSAIIPC LVGKGGLIIS DSLNHNSIVN 200
    GARGSGATVR VFQHNSPAHL EEVLREQIAG GQPRTHRPWK KIIVIVEGIY 250
    SMEGELCKLP EIIAVCKKYK AYTYLDEAHS IGAVGQSGRG VCELLGVDPA 300
    DVDIMMGTFT KSFGSCGGYI AASKEIIQHL KLSCPAHIYA TSMSPPAVQQ 350
    VISAIKVILG EDGSNRGAQK LARIRENSNF FRSELKKMGF EVLGDNDSPV 400
    MPIMLYNPAK IPAFSRECLR QKVAVVTVAF PATPLLLARA RICISASHTR 450
    EDLIKALDVI SRVGDLVGIK YFPAEPPKIA EADHDKLE 488
    Length:488
    Mass (Da):53,690
    Last modified:January 24, 2006 - v1
    Checksum:iE4478AE71F6F8373
    GO

    Sequence cautioni

    The sequence EEE52176.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti289 – 2891R → W in AK069007. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000010 Genomic DNA. Translation: ABA93932.1.
    AP008217 Genomic DNA. Translation: BAF28335.1.
    CM000148 Genomic DNA. Translation: EEE52176.1. Sequence problems.
    AK069007 mRNA. No translation available.
    RefSeqiNP_001067972.1. NM_001074504.1.
    UniGeneiOs.7816.

    Genome annotation databases

    EnsemblPlantsiOS11T0516000-01; OS11T0516000-01; OS11G0516000.
    GeneIDi4350591.
    KEGGiosa:4350591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000010 Genomic DNA. Translation: ABA93932.1 .
    AP008217 Genomic DNA. Translation: BAF28335.1 .
    CM000148 Genomic DNA. Translation: EEE52176.1 . Sequence problems.
    AK069007 mRNA. No translation available.
    RefSeqi NP_001067972.1. NM_001074504.1.
    UniGenei Os.7816.

    3D structure databases

    ProteinModelPortali Q2R3K3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS11T0516000-01 ; OS11T0516000-01 ; OS11G0516000 .
    GeneIDi 4350591.
    KEGGi osa:4350591.

    Organism-specific databases

    Gramenei Q2R3K3.

    Phylogenomic databases

    eggNOGi COG0156.
    KOi K00654.
    OMAi PEPGGCC.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_220105. Sphingolipid de novo biosynthesis.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLCB2A_ORYSJ
    AccessioniPrimary (citable) accession number: Q2R3K3
    Secondary accession number(s): B9GAX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3