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Q2R3A1

- CHS1_ORYSJ

UniProt

Q2R3A1 - CHS1_ORYSJ

Protein

Chalcone synthase 1

Gene

CHS1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671Acyl-thioester intermediatePROSITE-ProRule annotation
    Binding sitei200 – 2001SubstrateBy similarity
    Binding sitei311 – 3111Coenzyme A; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. auxin polar transport Source: EnsemblPlants/Gramene
    2. flavonoid biosynthetic process Source: UniProtKB-UniPathway
    3. regulation of anthocyanin biosynthetic process Source: EnsemblPlants/Gramene
    4. response to auxin Source: EnsemblPlants/Gramene
    5. response to gravity Source: EnsemblPlants/Gramene
    6. response to jasmonic acid Source: EnsemblPlants/Gramene
    7. response to oxidative stress Source: EnsemblPlants/Gramene
    8. response to UV-B Source: EnsemblPlants/Gramene
    9. response to wounding Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 1 (EC:2.3.1.74)
    Short name:
    OsCHS1
    Alternative name(s):
    Naregenin-chalcone synthase
    Gene namesi
    Name:CHS1
    Synonyms:CHS
    Ordered Locus Names:Os11g0530600, LOC_Os11g32650
    ORF Names:OsJ_032788
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 11

    Organism-specific databases

    GrameneiQ2R3A1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: EnsemblPlants/Gramene
    2. nucleus Source: EnsemblPlants/Gramene
    3. plant-type vacuole membrane Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Chalcone synthase 1PRO_0000216017Add
    BLAST

    Proteomic databases

    PRIDEiQ2R3A1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2R3A1.
    SMRiQ2R3A1. Positions 6-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 658Coenzyme A bindingBy similarity
    Regioni219 – 2202Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG3424.
    KOiK00660.
    OMAiQVEKPLF.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2R3A1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVTVEEV RRAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFRITKSE    50
    HMVELKEKFK RMCDKSQIRK RYMHLTEEIL QENPNMCAYM APSLDARQDI 100
    VVVEVPKLGK AAAQKAIKEW GQPRSRITHL VFCTTSGVDM PGADYQLAKM 150
    LGLRPNVNRL MMYQQGCFAG GTVLRVAKDL AENNRGARVL AVCSEITAVT 200
    FRGPSESHLD SMVGQALFGD GAAAVIVGSD PDEAVERPLF QMVSASQTIL 250
    PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALGDAF TPLGISDWNS 300
    IFWVAHPGGP AILDQVEAKV GLDKERMRAT RHVLSEYGNM SSACVLFILD 350
    EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PITAGAAA 398
    Length:398
    Mass (Da):43,265
    Last modified:January 24, 2006 - v1
    Checksum:iFD5D8C28FE60FAE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000801 mRNA. Translation: BAA19186.2.
    AB058397 Genomic DNA. Translation: BAB39764.1.
    DP000010 Genomic DNA. Translation: ABA94123.1.
    AP008217 Genomic DNA. Translation: BAF28372.1.
    CM000148 Genomic DNA. Translation: EAZ18579.1.
    RefSeqiNP_001068009.1. NM_001074541.1.
    UniGeneiOs.12416.

    Genome annotation databases

    EnsemblPlantsiOS11T0530600-01; OS11T0530600-01; OS11G0530600.
    GeneIDi4350636.
    KEGGiosa:4350636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000801 mRNA. Translation: BAA19186.2 .
    AB058397 Genomic DNA. Translation: BAB39764.1 .
    DP000010 Genomic DNA. Translation: ABA94123.1 .
    AP008217 Genomic DNA. Translation: BAF28372.1 .
    CM000148 Genomic DNA. Translation: EAZ18579.1 .
    RefSeqi NP_001068009.1. NM_001074541.1.
    UniGenei Os.12416.

    3D structure databases

    ProteinModelPortali Q2R3A1.
    SMRi Q2R3A1. Positions 6-392.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2R3A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS11T0530600-01 ; OS11T0530600-01 ; OS11G0530600 .
    GeneIDi 4350636.
    KEGGi osa:4350636.

    Organism-specific databases

    Gramenei Q2R3A1.

    Phylogenomic databases

    eggNOGi COG3424.
    KOi K00660.
    OMAi QVEKPLF.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and some characterization of single-copied chalcone synthase from rice."
      Minami E., He D., Minami N., Shibuya N.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
      Tissue: Leaf.
    2. "Molecular cloning and characterization of chalcone synthase (CHS) gene from rice (Oryza sativa L)."
      Ichikawa H., Okano E., Shimizu T., Nakamura S., Kawasaki S., Minami E.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    6. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiCHS1_ORYSJ
    AccessioniPrimary (citable) accession number: Q2R3A1
    Secondary accession number(s): P48405, P93710, Q9AVC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3