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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167Acyl-thioester intermediatePROSITE-ProRule annotation1
Binding sitei200SubstrateBy similarity1
Binding sitei311Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Short name:
OsCHS1
Alternative name(s):
Naregenin-chalcone synthase
Gene namesi
Name:CHS1
Synonyms:CHS
Ordered Locus Names:Os11g0530600, LOC_Os11g32650
ORF Names:OsJ_032788
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002160171 – 398Chalcone synthase 1Add BLAST398

Proteomic databases

PaxDbiQ2R3A1
PRIDEiQ2R3A1

Expressioni

Gene expression databases

ExpressionAtlasiQ2R3A1 baseline and differential
GenevisibleiQ2R3A1 OS

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os11g32650.1

Structurei

3D structure databases

ProteinModelPortaliQ2R3A1
SMRiQ2R3A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 65Coenzyme A bindingBy similarity8
Regioni219 – 220Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2 Eukaryota
COG3424 LUCA
InParanoidiQ2R3A1
KOiK00660
OMAiPIWGLGC
OrthoDBiEOG09360E8Q

Family and domain databases

Gene3Di3.40.47.102 hits
InterProiView protein in InterPro
IPR012328 Chalcone/stilbene_synth_C
IPR018088 Chalcone/stilbene_synthase_AS
IPR001099 Chalcone/stilbene_synthase_N
IPR011141 Polyketide_synthase_type-III
IPR016039 Thiolase-like
PANTHERiPTHR11877 PTHR11877, 1 hit
PfamiView protein in Pfam
PF02797 Chal_sti_synt_C, 1 hit
PF00195 Chal_sti_synt_N, 1 hit
PIRSFiPIRSF000451 PKS_III, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00441 CHALCONE_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

Q2R3A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVTVEEV RRAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFRITKSE
60 70 80 90 100
HMVELKEKFK RMCDKSQIRK RYMHLTEEIL QENPNMCAYM APSLDARQDI
110 120 130 140 150
VVVEVPKLGK AAAQKAIKEW GQPRSRITHL VFCTTSGVDM PGADYQLAKM
160 170 180 190 200
LGLRPNVNRL MMYQQGCFAG GTVLRVAKDL AENNRGARVL AVCSEITAVT
210 220 230 240 250
FRGPSESHLD SMVGQALFGD GAAAVIVGSD PDEAVERPLF QMVSASQTIL
260 270 280 290 300
PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALGDAF TPLGISDWNS
310 320 330 340 350
IFWVAHPGGP AILDQVEAKV GLDKERMRAT RHVLSEYGNM SSACVLFILD
360 370 380 390
EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PITAGAAA
Length:398
Mass (Da):43,265
Last modified:January 24, 2006 - v1
Checksum:iFD5D8C28FE60FAE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000801 mRNA Translation: BAA19186.2
AB058397 Genomic DNA Translation: BAB39764.1
DP000010 Genomic DNA Translation: ABA94123.1
AP008217 Genomic DNA Translation: BAF28372.1
AP014967 Genomic DNA Translation: BAT14279.1
CM000148 Genomic DNA Translation: EAZ18579.1
RefSeqiXP_015618054.1, XM_015762568.1
UniGeneiOs.12416

Genome annotation databases

EnsemblPlantsiOs11t0530600-01; Os11t0530600-01; Os11g0530600
GeneIDi4350636
GrameneiOs11t0530600-01; Os11t0530600-01; Os11g0530600
KEGGiosa:4350636

Similar proteinsi

Entry informationi

Entry nameiCHS1_ORYSJ
AccessioniPrimary (citable) accession number: Q2R3A1
Secondary accession number(s): A0A0P0Y338
, P48405, P93710, Q9AVC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 24, 2006
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome