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Protein

Laccase-19

Gene

LAC19

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1By similarity1
Metal bindingi88Copper 2By similarity1
Metal bindingi131Copper 2By similarity1
Metal bindingi133Copper 3By similarity1
Metal bindingi483Copper 4Sequence analysis1
Metal bindingi486Copper 1By similarity1
Metal bindingi488Copper 3By similarity1
Metal bindingi545Copper 3By similarity1
Metal bindingi546Copper 4Sequence analysis1
Metal bindingi547Copper 2By similarity1
Metal bindingi551Copper 4Sequence analysis1
Metal bindingi556Copper 4Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-19 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 19
Diphenol oxidase 19
Urishiol oxidase 19
Gene namesi
Name:LAC19
Ordered Locus Names:Os11g0641500, LOC_Os11g42200
ORF Names:OsJ_033252
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000029190529 – 590Laccase-19Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2R0L2.

Expressioni

Gene expression databases

GenevisibleiQ2R0L2. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g42200.1.

Structurei

3D structure databases

ProteinModelPortaliQ2R0L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 152Plastocyanin-like 1Add BLAST117
Domaini161 – 315Plastocyanin-like 2Add BLAST155
Domaini424 – 566Plastocyanin-like 3Add BLAST143

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ2R0L2.
OMAiVSFHHPT.
OrthoDBiEOG093605N6.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2R0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLSMVTSL LCAITVAVLA VAVVSGEAAV VEHTFVVHEM NATHLCNTTK
60 70 80 90 100
IYVVNGQFPG PTVDVTEGDT VVVHVINKLP FGLTIHWHGV RQMRSCWADG
110 120 130 140 150
AGFVTECPIP PGNEHTYRFN VTGQVGTLWW HAHVTCLRAT INGAFIVRPR
160 170 180 190 200
DGKYPFPTPA KDVPIIIGEW WELDLIELDR RMMDGNFDDN PLSATINGKL
210 220 230 240 250
GDLSNCSRMV EESFILDVKH GESYLLRVIN TALFSEYYFR VAGHTFTVVG
260 270 280 290 300
ADGNYLTPFK TDMVTVAPGE AIDVIMVADA PPAHYHMIAL ANQPPEPDPQ
310 320 330 340 350
IPVFTSRGLV RYAGTTANNN GLPVPMPIMP NQHNTMPSYY FHANLTGLAH
360 370 380 390 400
PERHRVPMHV DERLFVTLGL GSICRGQNTT CKRRRSPETI VVATMNNVSF
410 420 430 440 450
AHPKTTALLE RYYDGTSKGV YTEDFPIRPP RPFNYTNRDL IPPGPLEEAL
460 470 480 490 500
EPTFKATKLK RFKYNTSVEI IFQSTTLMQS DSNPMHLHGY DVFLLAQGLG
510 520 530 540 550
NFNAKRDVRK FNYHNPQLRN TVQVPRGGWA AIRFVTDNPG MWYLHCHFEF
560 570 580 590
HIIMGMATAF IVEDGPTPET SLPPPPPEFK RCGNNGLSQP
Length:590
Mass (Da):65,848
Last modified:January 24, 2006 - v1
Checksum:i451C018F129BD2E5
GO

Sequence cautioni

The sequence AK103094 differs from that shown. Reason: Frameshift at position 318.Curated
The sequence EAZ19043 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501N → K in EAZ19043 (PubMed:15685292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000010 Genomic DNA. Translation: ABA95017.1.
AP008217 Genomic DNA. Translation: BAF28716.1.
AP014967 Genomic DNA. Translation: BAT15010.1.
CM000148 Genomic DNA. Translation: EAZ19043.1. Sequence problems.
AK103094 mRNA. No translation available.
RefSeqiXP_015615642.1. XM_015760156.1.
UniGeneiOs.54291.

Genome annotation databases

EnsemblPlantsiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
GeneIDi4351005.
GrameneiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
KEGGiosa:4351005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000010 Genomic DNA. Translation: ABA95017.1.
AP008217 Genomic DNA. Translation: BAF28716.1.
AP014967 Genomic DNA. Translation: BAT15010.1.
CM000148 Genomic DNA. Translation: EAZ19043.1. Sequence problems.
AK103094 mRNA. No translation available.
RefSeqiXP_015615642.1. XM_015760156.1.
UniGeneiOs.54291.

3D structure databases

ProteinModelPortaliQ2R0L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os11g42200.1.

Proteomic databases

PaxDbiQ2R0L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
GeneIDi4351005.
GrameneiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
KEGGiosa:4351005.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ2R0L2.
OMAiVSFHHPT.
OrthoDBiEOG093605N6.

Gene expression databases

GenevisibleiQ2R0L2. OS.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC19_ORYSJ
AccessioniPrimary (citable) accession number: Q2R0L2
Secondary accession number(s): A0A0N7KT97, A3CD80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.