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Protein

Laccase-19

Gene

LAC19

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1By similarity1
Metal bindingi88Copper 2By similarity1
Metal bindingi131Copper 2By similarity1
Metal bindingi133Copper 3By similarity1
Metal bindingi483Copper 4Sequence analysis1
Metal bindingi486Copper 1By similarity1
Metal bindingi488Copper 3By similarity1
Metal bindingi545Copper 3By similarity1
Metal bindingi546Copper 4Sequence analysis1
Metal bindingi547Copper 2By similarity1
Metal bindingi551Copper 4Sequence analysis1
Metal bindingi556Copper 4Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-19 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 19
Diphenol oxidase 19
Urishiol oxidase 19
Gene namesi
Name:LAC19
Ordered Locus Names:Os11g0641500, LOC_Os11g42200
ORF Names:OsJ_033252
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000029190529 – 590Laccase-19Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2R0L2
PRIDEiQ2R0L2

Expressioni

Gene expression databases

ExpressionAtlasiQ2R0L2 differential
GenevisibleiQ2R0L2 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g42200.1

Structurei

3D structure databases

ProteinModelPortaliQ2R0L2
SMRiQ2R0L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 152Plastocyanin-like 1Add BLAST117
Domaini161 – 315Plastocyanin-like 2Add BLAST155
Domaini424 – 566Plastocyanin-like 3Add BLAST143

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
InParanoidiQ2R0L2
OMAiINHPITR
OrthoDBiEOG093605N6

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2R0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLSMVTSL LCAITVAVLA VAVVSGEAAV VEHTFVVHEM NATHLCNTTK
60 70 80 90 100
IYVVNGQFPG PTVDVTEGDT VVVHVINKLP FGLTIHWHGV RQMRSCWADG
110 120 130 140 150
AGFVTECPIP PGNEHTYRFN VTGQVGTLWW HAHVTCLRAT INGAFIVRPR
160 170 180 190 200
DGKYPFPTPA KDVPIIIGEW WELDLIELDR RMMDGNFDDN PLSATINGKL
210 220 230 240 250
GDLSNCSRMV EESFILDVKH GESYLLRVIN TALFSEYYFR VAGHTFTVVG
260 270 280 290 300
ADGNYLTPFK TDMVTVAPGE AIDVIMVADA PPAHYHMIAL ANQPPEPDPQ
310 320 330 340 350
IPVFTSRGLV RYAGTTANNN GLPVPMPIMP NQHNTMPSYY FHANLTGLAH
360 370 380 390 400
PERHRVPMHV DERLFVTLGL GSICRGQNTT CKRRRSPETI VVATMNNVSF
410 420 430 440 450
AHPKTTALLE RYYDGTSKGV YTEDFPIRPP RPFNYTNRDL IPPGPLEEAL
460 470 480 490 500
EPTFKATKLK RFKYNTSVEI IFQSTTLMQS DSNPMHLHGY DVFLLAQGLG
510 520 530 540 550
NFNAKRDVRK FNYHNPQLRN TVQVPRGGWA AIRFVTDNPG MWYLHCHFEF
560 570 580 590
HIIMGMATAF IVEDGPTPET SLPPPPPEFK RCGNNGLSQP
Length:590
Mass (Da):65,848
Last modified:January 24, 2006 - v1
Checksum:i451C018F129BD2E5
GO

Sequence cautioni

The sequence AK103094 differs from that shown. Reason: Frameshift at position 318.Curated
The sequence EAZ19043 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501N → K in EAZ19043 (PubMed:15685292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000010 Genomic DNA Translation: ABA95017.1
AP008217 Genomic DNA Translation: BAF28716.1
AP014967 Genomic DNA Translation: BAT15010.1
CM000148 Genomic DNA Translation: EAZ19043.1 Sequence problems.
AK103094 mRNA No translation available.
RefSeqiXP_015615642.1, XM_015760156.1
UniGeneiOs.54291

Genome annotation databases

EnsemblPlantsiOs11t0641500-01; Os11t0641500-01; Os11g0641500
GeneIDi4351005
GrameneiOs11t0641500-01; Os11t0641500-01; Os11g0641500
KEGGiosa:4351005

Similar proteinsi

Entry informationi

Entry nameiLAC19_ORYSJ
AccessioniPrimary (citable) accession number: Q2R0L2
Secondary accession number(s): A0A0N7KT97, A3CD80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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