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Q2R0L2

- LAC19_ORYSJ

UniProt

Q2R0L2 - LAC19_ORYSJ

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Protein

Laccase-19

Gene

LAC19

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Copper 1By similarity
Metal bindingi88 – 881Copper 2By similarity
Metal bindingi131 – 1311Copper 2By similarity
Metal bindingi133 – 1331Copper 3By similarity
Metal bindingi483 – 4831Copper 4Sequence Analysis
Metal bindingi486 – 4861Copper 1By similarity
Metal bindingi488 – 4881Copper 3By similarity
Metal bindingi545 – 5451Copper 3By similarity
Metal bindingi546 – 5461Copper 4Sequence Analysis
Metal bindingi547 – 5471Copper 2By similarity
Metal bindingi551 – 5511Copper 4Sequence Analysis
Metal bindingi556 – 5561Copper 4Sequence Analysis

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-19 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 19
Diphenol oxidase 19
Urishiol oxidase 19
Gene namesi
Name:LAC19
Ordered Locus Names:Os11g0641500, LOC_Os11g42200
ORF Names:OsJ_033252
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 11

Organism-specific databases

GrameneiQ2R0L2.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 590562Laccase-19PRO_0000291905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2R0L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 152117Plastocyanin-like 1Add
BLAST
Domaini161 – 315155Plastocyanin-like 2Add
BLAST
Domaini424 – 566143Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
InParanoidiQ2R0L2.
OMAiERHRVPM.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2R0L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLSMVTSL LCAITVAVLA VAVVSGEAAV VEHTFVVHEM NATHLCNTTK
60 70 80 90 100
IYVVNGQFPG PTVDVTEGDT VVVHVINKLP FGLTIHWHGV RQMRSCWADG
110 120 130 140 150
AGFVTECPIP PGNEHTYRFN VTGQVGTLWW HAHVTCLRAT INGAFIVRPR
160 170 180 190 200
DGKYPFPTPA KDVPIIIGEW WELDLIELDR RMMDGNFDDN PLSATINGKL
210 220 230 240 250
GDLSNCSRMV EESFILDVKH GESYLLRVIN TALFSEYYFR VAGHTFTVVG
260 270 280 290 300
ADGNYLTPFK TDMVTVAPGE AIDVIMVADA PPAHYHMIAL ANQPPEPDPQ
310 320 330 340 350
IPVFTSRGLV RYAGTTANNN GLPVPMPIMP NQHNTMPSYY FHANLTGLAH
360 370 380 390 400
PERHRVPMHV DERLFVTLGL GSICRGQNTT CKRRRSPETI VVATMNNVSF
410 420 430 440 450
AHPKTTALLE RYYDGTSKGV YTEDFPIRPP RPFNYTNRDL IPPGPLEEAL
460 470 480 490 500
EPTFKATKLK RFKYNTSVEI IFQSTTLMQS DSNPMHLHGY DVFLLAQGLG
510 520 530 540 550
NFNAKRDVRK FNYHNPQLRN TVQVPRGGWA AIRFVTDNPG MWYLHCHFEF
560 570 580 590
HIIMGMATAF IVEDGPTPET SLPPPPPEFK RCGNNGLSQP
Length:590
Mass (Da):65,848
Last modified:January 24, 2006 - v1
Checksum:i451C018F129BD2E5
GO

Sequence cautioni

The sequence AK103094 differs from that shown. Reason: Frameshift at position 318. Curated
The sequence EAZ19043.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti501 – 5011N → K in EAZ19043. (PubMed:15685292)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000010 Genomic DNA. Translation: ABA95017.1.
AP008217 Genomic DNA. Translation: BAF28716.1.
CM000148 Genomic DNA. Translation: EAZ19043.1. Sequence problems.
AK103094 mRNA. No translation available.
RefSeqiNP_001068353.1. NM_001074885.1.
UniGeneiOs.54291.

Genome annotation databases

EnsemblPlantsiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
GeneIDi4351005.
KEGGiosa:4351005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000010 Genomic DNA. Translation: ABA95017.1 .
AP008217 Genomic DNA. Translation: BAF28716.1 .
CM000148 Genomic DNA. Translation: EAZ19043.1 . Sequence problems.
AK103094 mRNA. No translation available.
RefSeqi NP_001068353.1. NM_001074885.1.
UniGenei Os.54291.

3D structure databases

ProteinModelPortali Q2R0L2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS11T0641500-01 ; OS11T0641500-01 ; OS11G0641500 .
GeneIDi 4351005.
KEGGi osa:4351005.

Organism-specific databases

Gramenei Q2R0L2.

Phylogenomic databases

eggNOGi COG2132.
InParanoidi Q2R0L2.
OMAi ERHRVPM.

Family and domain databases

Gene3Di 2.60.40.420. 4 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
    The rice chromosomes 11 and 12 sequencing consortia
    BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiLAC19_ORYSJ
AccessioniPrimary (citable) accession number: Q2R0L2
Secondary accession number(s): A3CD80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3