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Q2R0L2

- LAC19_ORYSJ

UniProt

Q2R0L2 - LAC19_ORYSJ

Protein

Laccase-19

Gene

LAC19

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Copper 1By similarity
    Metal bindingi88 – 881Copper 2By similarity
    Metal bindingi131 – 1311Copper 2By similarity
    Metal bindingi133 – 1331Copper 3By similarity
    Metal bindingi483 – 4831Copper 4Sequence Analysis
    Metal bindingi486 – 4861Copper 1By similarity
    Metal bindingi488 – 4881Copper 3By similarity
    Metal bindingi545 – 5451Copper 3By similarity
    Metal bindingi546 – 5461Copper 4Sequence Analysis
    Metal bindingi547 – 5471Copper 2By similarity
    Metal bindingi551 – 5511Copper 4Sequence Analysis
    Metal bindingi556 – 5561Copper 4Sequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-19 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 19
    Diphenol oxidase 19
    Urishiol oxidase 19
    Gene namesi
    Name:LAC19
    Ordered Locus Names:Os11g0641500, LOC_Os11g42200
    ORF Names:OsJ_033252
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 11

    Organism-specific databases

    GrameneiQ2R0L2.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 590562Laccase-19PRO_0000291905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ2R0L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 152117Plastocyanin-like 1Add
    BLAST
    Domaini161 – 315155Plastocyanin-like 2Add
    BLAST
    Domaini424 – 566143Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    OMAiERHRVPM.

    Family and domain databases

    Gene3Di2.60.40.420. 4 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2R0L2-1 [UniParc]FASTAAdd to Basket

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    MEKLSMVTSL LCAITVAVLA VAVVSGEAAV VEHTFVVHEM NATHLCNTTK    50
    IYVVNGQFPG PTVDVTEGDT VVVHVINKLP FGLTIHWHGV RQMRSCWADG 100
    AGFVTECPIP PGNEHTYRFN VTGQVGTLWW HAHVTCLRAT INGAFIVRPR 150
    DGKYPFPTPA KDVPIIIGEW WELDLIELDR RMMDGNFDDN PLSATINGKL 200
    GDLSNCSRMV EESFILDVKH GESYLLRVIN TALFSEYYFR VAGHTFTVVG 250
    ADGNYLTPFK TDMVTVAPGE AIDVIMVADA PPAHYHMIAL ANQPPEPDPQ 300
    IPVFTSRGLV RYAGTTANNN GLPVPMPIMP NQHNTMPSYY FHANLTGLAH 350
    PERHRVPMHV DERLFVTLGL GSICRGQNTT CKRRRSPETI VVATMNNVSF 400
    AHPKTTALLE RYYDGTSKGV YTEDFPIRPP RPFNYTNRDL IPPGPLEEAL 450
    EPTFKATKLK RFKYNTSVEI IFQSTTLMQS DSNPMHLHGY DVFLLAQGLG 500
    NFNAKRDVRK FNYHNPQLRN TVQVPRGGWA AIRFVTDNPG MWYLHCHFEF 550
    HIIMGMATAF IVEDGPTPET SLPPPPPEFK RCGNNGLSQP 590
    Length:590
    Mass (Da):65,848
    Last modified:January 24, 2006 - v1
    Checksum:i451C018F129BD2E5
    GO

    Sequence cautioni

    The sequence AK103094 differs from that shown. Reason: Frameshift at position 318.
    The sequence EAZ19043.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti501 – 5011N → K in EAZ19043. (PubMed:15685292)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000010 Genomic DNA. Translation: ABA95017.1.
    AP008217 Genomic DNA. Translation: BAF28716.1.
    CM000148 Genomic DNA. Translation: EAZ19043.1. Sequence problems.
    AK103094 mRNA. No translation available.
    RefSeqiNP_001068353.1. NM_001074885.1.
    UniGeneiOs.54291.

    Genome annotation databases

    EnsemblPlantsiOS11T0641500-01; OS11T0641500-01; OS11G0641500.
    GeneIDi4351005.
    KEGGiosa:4351005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000010 Genomic DNA. Translation: ABA95017.1 .
    AP008217 Genomic DNA. Translation: BAF28716.1 .
    CM000148 Genomic DNA. Translation: EAZ19043.1 . Sequence problems.
    AK103094 mRNA. No translation available.
    RefSeqi NP_001068353.1. NM_001074885.1.
    UniGenei Os.54291.

    3D structure databases

    ProteinModelPortali Q2R0L2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS11T0641500-01 ; OS11T0641500-01 ; OS11G0641500 .
    GeneIDi 4351005.
    KEGGi osa:4351005.

    Organism-specific databases

    Gramenei Q2R0L2.

    Phylogenomic databases

    eggNOGi COG2132.
    OMAi ERHRVPM.

    Family and domain databases

    Gene3Di 2.60.40.420. 4 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLAC19_ORYSJ
    AccessioniPrimary (citable) accession number: Q2R0L2
    Secondary accession number(s): A3CD80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3