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Reviewed, UniProtKB/Swiss-Prot Q2QY12 (ACA4_ORYSJ)

Last modified June 16, 2009. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable calcium-transporting ATPase 4, plasma membrane-type
    EC=3.6.3.8
Alternative name(s):
    Ca(2+)-ATPase isoform 4
Gene names
Ordered Locus Names: Os12g0136900, LOC_Os12g04220
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length1039 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles By similarity.

Catalytic activity

ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

Enzyme regulation

Activated by calmodulin By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Domain

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10391039Probable calcium-transporting ATPase 4, plasma membrane-type
PRO_0000247303

Regions

Topological domain1 – 175175Cytoplasmic Potential
Transmembrane176 – 19621 Potential
Transmembrane199 – 21921 Potential
Topological domain220 – 25031Cytoplasmic Potential
Transmembrane251 – 27121 Potential
Transmembrane353 – 37321 Potential
Topological domain374 – 40633Cytoplasmic Potential
Transmembrane407 – 42721 Potential
Transmembrane825 – 84521 Potential
Topological domain846 – 8472Cytoplasmic Potential
Transmembrane848 – 86821 Potential
Transmembrane892 – 91221 Potential
Topological domain913 – 96048Cytoplasmic Potential
Transmembrane961 – 98121 Potential
Transmembrane995 – 101521 Potential
Topological domain1016 – 103924Cytoplasmic Potential

Sites

Active site45614-aspartylphosphate intermediate By similarity
Metal binding7581Magnesium By similarity
Metal binding7621Magnesium By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2QY12-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 63E8DAEB9A6729B1

FASTA1,039113,842
        10         20         30         40         50         60 
MEKLDRYLQE NFDVPAKNPS EEAQRRWRQA VGTIVKNRRR RFRWVPDLER RSLDKAKVRS 

        70         80         90        100        110        120 
TQEKIRVALY VQQAALIFSD GAKKKEYKLT GDIIKAGYAI NPDELALITS KHDSKALKMH 

       130        140        150        160        170        180 
GGVDGISIKV RSSFDHGIYA SELDTRQNIY GVNRYAEKPS RSFWMFVWDA LQDMTLIILM 

       190        200        210        220        230        240 
VCALLSVAVG LATEGWPKGM YDGLGIILSI FLVVMVTAVS DYKQSLQFKE LDNEKKKIFI 

       250        260        270        280        290        300 
HVTRDGRRQK ISIYDLVVGD IVHLSIGDQV PADGLYIHGY SLLIDESSLS GESDPVYVSQ 

       310        320        330        340        350        360 
DKPFILAGTK VQDGSAKMIV TAVGMRTEWG KLMSTLSEGG EDETPLQVKL NGVATIIGKI 

       370        380        390        400        410        420 
GLVFAILTFL VLLVRFLIDK GMTVGLLKWY STDALTIVNY FATAVTIIVV AVPEGLPLAV 

       430        440        450        460        470        480 
TLSLAFAMKK LMNDKALVRH LSACETMGSA GTICTDKTGT LTTNHMVVDK IWISEVSKSV 

       490        500        510        520        530        540 
TSNTISGELN SVVSSSTLSL LLQGIFENTS AEVVKEKDGK QTVLGTPTER AILEFGLGLK 

       550        560        570        580        590        600 
GDHDAEYRAC TKVKVEPFNS VKKKMAVLIS LPNGTSRWFC KGASEIILQM CDMMVDGDGN 

       610        620        630        640        650        660 
AIPLSEAQRK NILDTINSFA SDALRTLCLA YKEVDDDIDD NADSPTSGFT LIAIFGIKDP 

       670        680        690        700        710        720 
VRPGVKDAVK TCMSAGITVR MVTGDNINTA KAIAKECGIL TEDGVAIEGP EFHSKSTEEM 

       730        740        750        760        770        780 
RDLILNIQVM ARSLPLDKHT LVTNLRGMFD EVVSVTGDGT NDAPALHEAD IGLAMGIAGT 

       790        800        810        820        830        840 
EVAKESADVI VLDDNFTTII NVARWGRAVY INIQKFVQFQ LTVNIVALVI NFVSACIIGS 

       850        860        870        880        890        900 
APLTAVQLLW VNMIMDTLGA LALATEPPND EMMKRPPVRK GESFITKFMW RNIMGQSLYQ 

       910        920        930        940        950        960 
LFVLGALMFG GERLLNIKGA DSKSIINTLI FNSFVFCQVF NEINSREMQK INVFRGIISN 

       970        980        990       1000       1010       1020 
WIFIAVIAAT VAFQVVIIEF LGTFASTVPL NWQHWLLSVG LGSISLIVGV ILKCIPVGSG 

      1030 
ETSATPNGYR PLANGPDDI

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References

[1]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

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Cross-references

Sequence databases

DP000011 Genomic DNA. Translation: ABA95758.1.
RefSeqNP_001066105.1.
UniGeneOs.79627

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4351449.
KEGGosa:4351449.

Organism-specific databases

GrameneQ2QY12.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR006408. ATPase_P-typ_Ca-transp_PMCA.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_phosphor_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
TIGRFAMsTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameACA4_ORYSJ
AccessionPrimary (citable) accession number: Q2QY12
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 24, 2006
Last modified: June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents