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Q2QUN2

- LAC24_ORYSJ

UniProt

Q2QUN2 - LAC24_ORYSJ

Protein

Laccase-24

Gene

LAC24

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi82 – 821Copper 1By similarity
    Metal bindingi84 – 841Copper 2By similarity
    Metal bindingi127 – 1271Copper 2By similarity
    Metal bindingi129 – 1291Copper 3By similarity
    Metal bindingi480 – 4801Copper 4By similarity
    Metal bindingi483 – 4831Copper 1By similarity
    Metal bindingi485 – 4851Copper 3By similarity
    Metal bindingi542 – 5421Copper 3By similarity
    Metal bindingi543 – 5431Copper 4By similarity
    Metal bindingi544 – 5441Copper 2By similarity
    Metal bindingi548 – 5481Copper 4By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-24 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 24
    Diphenol oxidase 24
    Urishiol oxidase 24
    Gene namesi
    Name:LAC24
    Ordered Locus Names:Os12g0258700, LOC_Os12g15680
    ORF Names:OsJ_016843, OsJ_17624
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 12

    Organism-specific databases

    GrameneiQ2QUN2.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 579556Laccase-24PRO_0000291911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os12g15680.1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 148118Plastocyanin-like 1Add
    BLAST
    Domaini159 – 322164Plastocyanin-like 2Add
    BLAST
    Domaini425 – 563139Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 5 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2QUN2-1 [UniParc]FASTAAdd to Basket

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    MARSWSLLLL PFALALVASV AQAAVVEYTF NVGNLSISQL CQQEMIITAV    50
    NGQLPGPTIV ATEGDTVVVH MVNESPYNMT IHWHGIFQRG TPWADGPAMV 100
    TQCPVRPGGN YTYRFNVTGQ EGTLWWHSHF SFLRATVYGA LIIKPRGGAK 150
    AYPFPVPDEE VVVILGEWWK TNVYDLQQRS LVTGNPAPHA DAYTINGKPG 200
    DFYNCSAPNQ THKFELKQNK TYMLRIINAA LNTPLFFKVA NHSFNVVAAD 250
    ACYTKPYKTD VVVISPGQTV DALLVPDAGV AAAVGGRYYM AVIPYNSAVN 300
    AADPSFLYSL TNSTAIVEYG GGPATSPPMV PDMPEYNDTA TAHRFLSNMT 350
    ALVPNRVPLA VDTHMFVTVS MGDTFCGPEQ TMCMPDDKGT IFASSMNNAS 400
    FILPNTTSML EAMYKGSIDG VYTRDFPDTP PIVFDYTADA SDDNATLKHT 450
    FKSTKVKTLK YNSTVQMVLQ NTRLVSKESH PMHLHGFNFF VLAQGFGNYN 500
    ETTDPAKFNL VDPQERNTVA VPTGGWAVIR FVADNPGVWF MHCHFDAHLE 550
    FGLGMVFEVQ NGPTQETSLP PPPSDLPQC 579
    Length:579
    Mass (Da):63,459
    Last modified:January 24, 2006 - v1
    Checksum:iFD10AEC0CC9EB013
    GO

    Sequence cautioni

    The sequence BAH01413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000011 Genomic DNA. Translation: ABA97304.1.
    AP008218 Genomic DNA. Translation: BAF29536.2.
    CM000142 Genomic DNA. Translation: EEE62821.1.
    AK243030 mRNA. Translation: BAH01413.1. Different initiation.
    RefSeqiNP_001066517.2. NM_001073049.2.
    UniGeneiOs.78609.

    Genome annotation databases

    GeneIDi4351915.
    KEGGiosa:4351915.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000011 Genomic DNA. Translation: ABA97304.1 .
    AP008218 Genomic DNA. Translation: BAF29536.2 .
    CM000142 Genomic DNA. Translation: EEE62821.1 .
    AK243030 mRNA. Translation: BAH01413.1 . Different initiation.
    RefSeqi NP_001066517.2. NM_001073049.2.
    UniGenei Os.78609.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os12g15680.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4351915.
    KEGGi osa:4351915.

    Organism-specific databases

    Gramenei Q2QUN2.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 5 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Oryza sativa full-length cDNA."
      The rice full-length cDNA consortium
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLAC24_ORYSJ
    AccessioniPrimary (citable) accession number: Q2QUN2
    Secondary accession number(s): B7F9W5, B9FJ53, Q0IP29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3