ID   MT4C_ORYSJ              Reviewed;          78 AA.
AC   Q2QNC3; B7EXP4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Metallothionein-like protein 4C;
DE   AltName: Full=Class I metallothionein-like protein 4C;
DE   AltName: Full=MT-1-4b {ECO:0000303|PubMed:21297036};
DE   AltName: Full=OsMT-I-4c;
DE   AltName: Full=OsMT1c;
GN   Name=MT4C; OrderedLocusNames=Os12g0571100, LOC_Os12g38300;
GN   ORFNames=OsJ_36585 {ECO:0000312|EMBL:EEE53461.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Root;
RA   Bohnert H.J., Borchert C., Brazille S., Brooks J., Eaton M., Ferrea H.,
RA   Kawasaki S., McCollough A., Michalowski C.B., Palacio C., Scara G.,
RA   Wheeler M., Zepeda G.R.;
RT   "Functional genomics of plant stress tolerance.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [8]
RP   GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=17002881; DOI=10.5483/bmbrep.2006.39.5.595;
RA   Zhou G., Xu Y., Li J., Yang L., Liu J.-Y.;
RT   "Molecular analyses of the metallothionein gene family in rice (Oryza
RT   sativa L.).";
RL   J. Biochem. Mol. Biol. 39:595-606(2006).
RN   [9]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=21297036; DOI=10.1105/tpc.110.074369;
RA   Hu L., Liang W., Yin C., Cui X., Zong J., Wang X., Hu J., Zhang D.;
RT   "Rice MADS3 regulates ROS homeostasis during late anther development.";
RL   Plant Cell 23:515-533(2011).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC       that bind various heavy metals (Probable). Acts as a reactive oxygen
CC       species (ROS) scavenger. Possesses superoxide anion and hydroxyl
CC       radical scavenging activities in vitro. Involved in ROS homeostasis
CC       during anther and pollen development (PubMed:21297036).
CC       {ECO:0000269|PubMed:21297036, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in roots (PubMed:21297036).
CC       Expressed in leaves, rachis, inflorescences and seeds
CC       (PubMed:17002881). {ECO:0000269|PubMed:17002881,
CC       ECO:0000269|PubMed:21297036}.
CC   -!- DEVELOPMENTAL STAGE: During anther development, expressed from stage 8
CC       to stage 12. {ECO:0000269|PubMed:21297036}.
CC   -!- MISCELLANEOUS: Plants silencing MT4C show decreased pollen fertility
CC       and increased level of superoxide anion. {ECO:0000269|PubMed:21297036}.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 15 family.
CC       {ECO:0000305}.
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DR   EMBL; BE039221; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DP000011; ABA99661.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF30102.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT17739.1; -; Genomic_DNA.
DR   EMBL; CM000149; EEE53461.1; -; Genomic_DNA.
DR   EMBL; AK105219; BAG97141.1; -; mRNA.
DR   RefSeq; XP_015620236.1; XM_015764750.1.
DR   AlphaFoldDB; Q2QNC3; -.
DR   STRING; 39947.Q2QNC3; -.
DR   PaxDb; 39947-Q2QNC3; -.
DR   EnsemblPlants; Os12t0571100-01; Os12t0571100-01; Os12g0571100.
DR   GeneID; 4352582; -.
DR   Gramene; Os12t0571100-01; Os12t0571100-01; Os12g0571100.
DR   KEGG; osa:4352582; -.
DR   eggNOG; KOG4738; Eukaryota.
DR   HOGENOM; CLU_161105_1_0_1; -.
DR   InParanoid; Q2QNC3; -.
DR   OMA; TEGGHAC; -.
DR   OrthoDB; 623384at2759; -.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009555; P:pollen development; IMP:UniProtKB.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
DR   InterPro; IPR000347; Metalthion_15p.
DR   PANTHER; PTHR33543; METALLOTHIONEIN-LIKE PROTEIN 2A; 1.
DR   PANTHER; PTHR33543:SF42; METALLOTHIONEIN-LIKE PROTEIN 4B; 1.
DR   Pfam; PF01439; Metallothio_2; 1.
DR   Genevisible; Q2QNC3; OS.
PE   2: Evidence at transcript level;
KW   Metal-binding; Metal-thiolate cluster; Reference proteome; Stress response.
FT   CHAIN           1..78
FT                   /note="Metallothionein-like protein 4C"
FT                   /id="PRO_0000263061"
SQ   SEQUENCE   78 AA;  7514 MW;  0AF2B6CBEBC51E13 CRC64;
     MSCGGSCNCG SCGCGGGCGK MYPDLAEKIT TTTTTATTVL GVAPEKGHSE GVGKAAESGE
     AAHGCSCGSS CRCNPCNC
//