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Q2QLH9 (TES_OTOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Testin
Gene names
Name:TES
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) [Reference proteome]
Taxonomic identifier30611 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Strepsirrhini › Lorisiformes › Galagidae › Otolemur

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor By similarity.

Subunit structure

Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with talin, actin, alpha-actinin, GRIP1 and PXN By similarity. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer By similarity.

Subcellular location

Cytoplasm By similarity. Cell junction › focal adhesion By similarity. Note: Detected along actin stress fibers By similarity.

Domain

The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX By similarity.

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

Ontologies

Keywords
   Cellular componentCell junction
Cytoplasm
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

focal adhesion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Testin
PRO_0000226349

Regions

Domain92 – 199108PET
Domain234 – 29764LIM zinc-binding 1
Domain299 – 35961LIM zinc-binding 2
Domain362 – 42160LIM zinc-binding 3

Sequences

Sequence LengthMass (Da)Tools
Q2QLH9 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: CA03E967E388F09E

FASTA42148,281
        10         20         30         40         50         60 
MDVETKIKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDILLSNEED 

        70         80         90        100        110        120 
RKVGRLFEDT KYSTLIAKLK SDGIPMYKRN VMILTNPVPA KKNVSINTVT YEWAPPVQNQ 

       130        140        150        160        170        180 
ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PTKCHELSPK EVKEMEQFVK 

       190        200        210        220        230        240 
KYKNEALGVG DVKLPREVVD QGPNQMYIPG GDRSTSAAVG AMENKSHEHR RTHYACYCCK 

       250        260        270        280        290        300 
MNMKEGDPAI YAERAGYDKL WHPACFVCSI CYELLVDMIY FWKNEKLYCG RHYCDSEKPR 

       310        320        330        340        350        360 
CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDNVLAGEIY VMVNDKPVCK PCYVKNHAVV 

       370        380        390        400        410        420 
CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVKCKKMM 


S

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DP000013 Genomic DNA. Translation: ABA90399.1.

3D structure databases

ProteinModelPortalQ2QLH9.
SMRQ2QLH9. Positions 357-420.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000231628.
HOVERGENHBG001038.
OrthoDBEOG4P8FK5.

Family and domain databases

Gene3D2.10.110.10. 3 hits.
InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTES_OTOGA
AccessionPrimary (citable) accession number: Q2QLH9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 24, 2006
Last modified: April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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