Q2QJL3 (Q2QJL3_ACEAC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338
Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338

Gene names

Name:

purE EMBL AAZ04483.1

Organism

Acetobacter aceti EMBL AAZ04483.1

Taxonomic identifier

435 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acetobacter › Acetobacter subgen. Acetobacter

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338
Sequence similarities	Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Ontologies

Keywords
Biological process	Purine biosynthesis PIRNR PIRNR001338
Molecular function	Isomerase PIRNR PIRNR001338
Technical term	3D-structure PDB 2FW6 PDB 2FWI PDB 2FW8 PDB 2FWJ PDB 2FW7 PDB 2FW9 PDB 2FWB PDB 2FW1 PDB 2FWP PDB 2FWA PDB 1U11
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2QJL3 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: BA1F9245440138E8	FASTA	182	18,735
	10 20 30 40 50 60 MSETAPLPSA SSALEDKAAS APVVGIIMGS QSDWETMRHA DALLTELEIP HETLIVSAHR 70 80 90 100 110 120 TPDRLADYAR TAAERGLNVI IAGAGGAAHL PGMCAAWTRL PVLGVPVESR ALKGMDSLLS 130 140 150 160 170 180 IVQMPGGVPV GTLAIGASGA KNAALLAASI LALYNPALAA RLETWRALQT ASVPNSPITE DK

References

[1]	"Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti." Constantine C.Z., Starks C.M., Mill C.P., Ransome A.E., Karpowicz S.J., Francois J.A., Goodman R.A., Kappock T.J. Biochemistry 45:8193-8208(2006) [PubMed: 16819818] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 1023 EMBL AAZ04483.1.
[2]	"Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)." Settembre E.C., Chittuluru J.R., Mill C.P., Kappock T.J., Ealick S.E. Acta Crystallogr. D Biol. Crystallogr. 60:1753-1760(2004) [PubMed: 15388921] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ059549 Genomic DNA. Translation: AAZ04483.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1U11	X-ray	1.55	A/B	1-182	[»]
2FW1	X-ray	2.00	A/B	1-182	[»]
2FW6	X-ray	1.85	A/B	1-182	[»]
2FW7	X-ray	1.75	A/B	1-182	[»]
2FW8	X-ray	1.75	A/B	1-182	[»]
2FW9	X-ray	1.75	A/B	1-182	[»]
2FWA	X-ray	1.90	A/B	1-182	[»]
2FWB	X-ray	2.00	A/B	1-182	[»]
2FWI	X-ray	1.94	A/B	1-182	[»]
2FWJ	X-ray	1.95	A/B	1-182	[»]
2FWP	X-ray	1.85	A/B	1-182	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR024694. N5-CAIR_mutase_PurE.
IPR000031. N5-CAIR_Mutase_PurE_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.

Pfam

PF00731. AIRC. 1 hit.
[Graphical view]

PIRSF

PIRSF001338. AIR_carboxylase. 1 hit.

SMART

SM01001. AIRC. 1 hit.
[Graphical view]

SUPFAM

SSF52255. AIR_carboxyl. 1 hit.

TIGRFAMs

TIGR01162. PurE. 1 hit.

ProtoNet

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Entry information

Entry name

Q2QJL3_ACEAC

Accession

Primary (citable) accession number: Q2QJL3

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)