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Q2QGD7 (ZXDC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein ZXDC
Alternative name(s):
ZXD-like zinc finger protein
Gene names
Name:ZXDC
Synonyms:ZXDL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Ref.1 Ref.7 Ref.8

Subunit structure

Self-associates. Interacts with ZXDA and CIITA. Ref.1 Ref.8

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen. Ref.1

Post-translational modification

Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain. Ref.7

Sequence similarities

Belongs to the ZXD family.

Contains 10 C2H2-type zinc fingers.

Sequence caution

The sequence BAC03805.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2QGD7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2QGD7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     710-710: E → V
     711-858: Missing.
Isoform 3 (identifier: Q2QGD7-3)

Also known as: ZXDC2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-258: Missing.
     710-710: E → V
     711-858: Missing.
Note: Doesn't interact with CIITA. Represses MHC class II transcription possibly via dominant-negative association with isoform 1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Zinc finger protein ZXDC
PRO_0000292803

Regions

Zinc finger175 – 19925C2H2-type 1
Zinc finger208 – 23225C2H2-type 2
Zinc finger238 – 26225C2H2-type 3
Zinc finger268 – 29023C2H2-type 4
Zinc finger297 – 32125C2H2-type 5
Zinc finger328 – 35225C2H2-type 6
Zinc finger358 – 38225C2H2-type 7
Zinc finger388 – 41225C2H2-type 8
Zinc finger418 – 44225C2H2-type 9
Zinc finger451 – 47626C2H2-type 10
Region579 – 688110Required for transcriptional activation
Region781 – 85878Interaction with CIITA

Amino acid modifications

Cross-link660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.7

Natural variations

Alternative sequence1 – 258258Missing in isoform 3.
VSP_047464
Alternative sequence7101E → V in isoform 2 and isoform 3.
VSP_026437
Alternative sequence711 – 858148Missing in isoform 2 and isoform 3.
VSP_026438
Natural variant5621P → L. Ref.2
Corresponds to variant rs16837497 [ dbSNP | Ensembl ].
VAR_057464

Experimental info

Sequence conflict1181P → A in AAX23974. Ref.1
Sequence conflict1181P → A in AAZ30918. Ref.3
Sequence conflict6831Q → H in AAH73859. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 8C35F5685CF1E695

FASTA85889,988
        10         20         30         40         50         60 
MDLPALLPAP TARGGQHGGG PGPLRRAPAP LGASPARRRL LLVRGPEDGG PGARPGEASG 

        70         80         90        100        110        120 
PSPPPAEDDS DGDSFLVLLE VPHGGAAAEA AGSQEAEPGS RVNLASRPEQ GPSGPAAPPG 

       130        140        150        160        170        180 
PGVAPAGAVT ISSQDLLVRL DRGVLALSAP PGPATAGAAA PRRAPQASGP STPGYRCPEP 

       190        200        210        220        230        240 
QCALAFAKKH QLKVHLLTHG GGQGRRPFKC PLEGCGWAFT TSYKLKRHLQ SHDKLRPFGC 

       250        260        270        280        290        300 
PVGGCGKKFT TVYNLKAHMK GHEQESLFKC EVCAERFPTH AKLSSHQRSH FEPERPYKCD 

       310        320        330        340        350        360 
FPGCEKTFIT VSALFSHNRA HFREQELFSC SFPGCSKQYD KACRLKIHLR SHTGERPFIC 

       370        380        390        400        410        420 
DSDSCGWTFT SMSKLLRHRR KHDDDRRFTC PVEGCGKSFT RAEHLKGHSI THLGTKPFEC 

       430        440        450        460        470        480 
PVEGCCARFS ARSSLYIHSK KHVQDVGAPK SRCPVSTCNR LFTSKHSMKA HMVRQHSRRQ 

       490        500        510        520        530        540 
DLLPQLEAPS SLTPSSELSS PGQSELTNMD LAALFSDTPA NASGSAGGSD EALNSGILTI 

       550        560        570        580        590        600 
DVTSVSSSLG GNLPANNSSL GPMEPLVLVA HSDIPPSLDS PLVLGTAATV LQQGSFSVDD 

       610        620        630        640        650        660 
VQTVSAGALG CLVALPMKNL SDDPLALTSN SNLAAHITTP TSSSTPRENA SVPELLAPIK 

       670        680        690        700        710        720 
VEPDSPSRPG AVGQQEGSHG LPQSTLPSPA EQHGAQDTEL SAGTGNFYLE SGGSARTDYR 

       730        740        750        760        770        780 
AIQLAKEKKQ RGAGSNAGAS QSTQRKIKEG KMSPPHFHAS QNSWLCGSLV VPSGGRPGPA 

       790        800        810        820        830        840 
PAAGVQCGAQ GVQVQLVQDD PSGEGVLPSA RGPATFLPFL TVDLPVYVLQ EVLPSSGGPA 

       850 
GPEATQFPGS TINLQDLQ 

« Hide

Isoform 2 [UniParc].

Checksum: 0B2CE6ADCC39E7FD
Show »

FASTA71074,817
Isoform 3 (ZXDC2) [UniParc].

Checksum: DCFED7A4DF0B2129
Show »

FASTA45248,685

References

« Hide 'large scale' references
[1]"ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription."
Al-Kandari W., Jambunathan S., Navalgund V., Koneni R., Freer M., Parimi N., Mudhasani R., Fontes J.D.
Mol. Immunol. 44:311-321(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CIITA, TISSUE SPECIFICITY.
[2]"An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription."
Aleksandrova A., Galkin O., Koneni R., Fontes J.D.
Mol. Cell. Biochem. 337:1-7(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT LEU-562.
[3]"Cloning and characterization of the ZXDL gene which encodes a putative zinc finger protein."
Tang W.W., Tang Z.H., Yu L.
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-858 (ISOFORM 2).
Tissue: Teratocarcinoma.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-858 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-710 (ISOFORM 2).
Tissue: Placenta, Skin and Testis.
[7]"Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain."
Jambunathan S., Fontes J.D.
Biol. Chem. 388:965-972(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION AT LYS-660, FUNCTION.
[8]"The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription."
Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D.
J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDA AND CIITA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY936556 mRNA. Translation: AAX23974.1.
FJ980275 mRNA. Translation: ACR56328.1.
DQ079590 mRNA. Translation: AAZ30918.1.
AC024558 Genomic DNA. No translation available.
AC073439 Genomic DNA. No translation available.
AK092101 mRNA. Translation: BAC03805.1. Different initiation.
BC002940 mRNA. Translation: AAH02940.2.
BC012729 mRNA. Translation: AAH12729.2.
BC073859 mRNA. Translation: AAH73859.1.
RefSeqNP_001035743.1. NM_001040653.3.
NP_079388.3. NM_025112.4.
UniGeneHs.440049.
Hs.711046.

3D structure databases

ProteinModelPortalQ2QGD7.
SMRQ2QGD7. Positions 167-477.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122653. 10 interactions.
IntActQ2QGD7. 8 interactions.
MINTMINT-8247508.
STRING9606.ENSP00000374359.

PTM databases

PhosphoSiteQ2QGD7.

Polymorphism databases

DMDM296453026.

Proteomic databases

PaxDbQ2QGD7.
PRIDEQ2QGD7.

Protocols and materials databases

DNASU79364.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336332; ENSP00000337694; ENSG00000070476. [Q2QGD7-2]
ENST00000389709; ENSP00000374359; ENSG00000070476. [Q2QGD7-1]
GeneID79364.
KEGGhsa:79364.
UCSCuc003eiv.3. human. [Q2QGD7-1]
uc003eix.2. human. [Q2QGD7-2]

Organism-specific databases

CTD79364.
GeneCardsGC03M126156.
HGNCHGNC:28160. ZXDC.
HPAHPA049593.
neXtProtNX_Q2QGD7.
PharmGKBPA142670466.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000013019.
HOVERGENHBG002277.
InParanoidQ2QGD7.
OMAPLEGCGW.
OrthoDBEOG776SPF.
PhylomeDBQ2QGD7.
TreeFamTF330996.

Gene expression databases

ArrayExpressQ2QGD7.
BgeeQ2QGD7.
CleanExHS_ZXDC.
GenevestigatorQ2QGD7.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZXDC. human.
GenomeRNAi79364.
NextBio35482958.
PROQ2QGD7.

Entry information

Entry nameZXDC_HUMAN
AccessionPrimary (citable) accession number: Q2QGD7
Secondary accession number(s): C5J0H9 expand/collapse secondary AC list , Q6DKI8, Q7L3L1, Q8NAU2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM