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Q2QGD7

- ZXDC_HUMAN

UniProt

Q2QGD7 - ZXDC_HUMAN

Protein

Zinc finger protein ZXDC

Gene

ZXDC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri208 – 23225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri238 – 26225C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri297 – 32125C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35225C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38225C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41225C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44225C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri451 – 47626C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. C2H2 zinc finger domain binding Source: UniProtKB
    2. LRR domain binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. nucleic acid binding Source: InterPro
    5. protein binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZXDC
    Alternative name(s):
    ZXD-like zinc finger protein
    Gene namesi
    Name:ZXDC
    Synonyms:ZXDL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28160. ZXDC.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670466.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Zinc finger protein ZXDCPRO_0000292803Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki660 – 660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

    Post-translational modificationi

    Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ2QGD7.
    PaxDbiQ2QGD7.
    PRIDEiQ2QGD7.

    PTM databases

    PhosphoSiteiQ2QGD7.

    Expressioni

    Tissue specificityi

    Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ2QGD7.
    BgeeiQ2QGD7.
    CleanExiHS_ZXDC.
    GenevestigatoriQ2QGD7.

    Organism-specific databases

    HPAiHPA049593.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with ZXDA and CIITA.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CIITAP330766EBI-1538838,EBI-1538819
    ZXDAP981685EBI-1538838,EBI-1538980

    Protein-protein interaction databases

    BioGridi122653. 10 interactions.
    IntActiQ2QGD7. 9 interactions.
    MINTiMINT-8247508.
    STRINGi9606.ENSP00000374359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2QGD7.
    SMRiQ2QGD7. Positions 167-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni579 – 688110Required for transcriptional activationAdd
    BLAST
    Regioni781 – 85878Interaction with CIITAAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ZXD family.Curated
    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri208 – 23225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri238 – 26225C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri297 – 32125C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35225C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38225C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41225C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri418 – 44225C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri451 – 47626C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013019.
    HOVERGENiHBG002277.
    InParanoidiQ2QGD7.
    OMAiPLEGCGW.
    OrthoDBiEOG776SPF.
    PhylomeDBiQ2QGD7.
    TreeFamiTF330996.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 3 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2QGD7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLPALLPAP TARGGQHGGG PGPLRRAPAP LGASPARRRL LLVRGPEDGG    50
    PGARPGEASG PSPPPAEDDS DGDSFLVLLE VPHGGAAAEA AGSQEAEPGS 100
    RVNLASRPEQ GPSGPAAPPG PGVAPAGAVT ISSQDLLVRL DRGVLALSAP 150
    PGPATAGAAA PRRAPQASGP STPGYRCPEP QCALAFAKKH QLKVHLLTHG 200
    GGQGRRPFKC PLEGCGWAFT TSYKLKRHLQ SHDKLRPFGC PVGGCGKKFT 250
    TVYNLKAHMK GHEQESLFKC EVCAERFPTH AKLSSHQRSH FEPERPYKCD 300
    FPGCEKTFIT VSALFSHNRA HFREQELFSC SFPGCSKQYD KACRLKIHLR 350
    SHTGERPFIC DSDSCGWTFT SMSKLLRHRR KHDDDRRFTC PVEGCGKSFT 400
    RAEHLKGHSI THLGTKPFEC PVEGCCARFS ARSSLYIHSK KHVQDVGAPK 450
    SRCPVSTCNR LFTSKHSMKA HMVRQHSRRQ DLLPQLEAPS SLTPSSELSS 500
    PGQSELTNMD LAALFSDTPA NASGSAGGSD EALNSGILTI DVTSVSSSLG 550
    GNLPANNSSL GPMEPLVLVA HSDIPPSLDS PLVLGTAATV LQQGSFSVDD 600
    VQTVSAGALG CLVALPMKNL SDDPLALTSN SNLAAHITTP TSSSTPRENA 650
    SVPELLAPIK VEPDSPSRPG AVGQQEGSHG LPQSTLPSPA EQHGAQDTEL 700
    SAGTGNFYLE SGGSARTDYR AIQLAKEKKQ RGAGSNAGAS QSTQRKIKEG 750
    KMSPPHFHAS QNSWLCGSLV VPSGGRPGPA PAAGVQCGAQ GVQVQLVQDD 800
    PSGEGVLPSA RGPATFLPFL TVDLPVYVLQ EVLPSSGGPA GPEATQFPGS 850
    TINLQDLQ 858
    Length:858
    Mass (Da):89,988
    Last modified:May 18, 2010 - v2
    Checksum:i8C35F5685CF1E695
    GO
    Isoform 2 (identifier: Q2QGD7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         710-710: E → V
         711-858: Missing.

    Show »
    Length:710
    Mass (Da):74,817
    Checksum:i0B2CE6ADCC39E7FD
    GO
    Isoform 3 (identifier: Q2QGD7-3) [UniParc]FASTAAdd to Basket

    Also known as: ZXDC2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-258: Missing.
         710-710: E → V
         711-858: Missing.

    Note: Doesn't interact with CIITA. Represses MHC class II transcription possibly via dominant-negative association with isoform 1.

    Show »
    Length:452
    Mass (Da):48,685
    Checksum:iDCFED7A4DF0B2129
    GO

    Sequence cautioni

    The sequence BAC03805.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181P → A in AAX23974. (PubMed:16600381)Curated
    Sequence conflicti118 – 1181P → A in AAZ30918. 1 PublicationCurated
    Sequence conflicti683 – 6831Q → H in AAH73859. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti562 – 5621P → L.1 Publication
    Corresponds to variant rs16837497 [ dbSNP | Ensembl ].
    VAR_057464

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 258258Missing in isoform 3. 1 PublicationVSP_047464Add
    BLAST
    Alternative sequencei710 – 7101E → V in isoform 2 and isoform 3. 3 PublicationsVSP_026437
    Alternative sequencei711 – 858148Missing in isoform 2 and isoform 3. 3 PublicationsVSP_026438Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY936556 mRNA. Translation: AAX23974.1.
    FJ980275 mRNA. Translation: ACR56328.1.
    DQ079590 mRNA. Translation: AAZ30918.1.
    AC024558 Genomic DNA. No translation available.
    AC073439 Genomic DNA. No translation available.
    AK092101 mRNA. Translation: BAC03805.1. Different initiation.
    BC002940 mRNA. Translation: AAH02940.2.
    BC012729 mRNA. Translation: AAH12729.2.
    BC073859 mRNA. Translation: AAH73859.1.
    CCDSiCCDS43145.1. [Q2QGD7-1]
    CCDS43146.1. [Q2QGD7-2]
    RefSeqiNP_001035743.1. NM_001040653.3. [Q2QGD7-2]
    NP_079388.3. NM_025112.4. [Q2QGD7-1]
    UniGeneiHs.440049.
    Hs.711046.

    Genome annotation databases

    EnsembliENST00000336332; ENSP00000337694; ENSG00000070476. [Q2QGD7-2]
    ENST00000389709; ENSP00000374359; ENSG00000070476. [Q2QGD7-1]
    GeneIDi79364.
    KEGGihsa:79364.
    UCSCiuc003eiv.3. human. [Q2QGD7-1]
    uc003eix.2. human. [Q2QGD7-2]

    Polymorphism databases

    DMDMi296453026.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY936556 mRNA. Translation: AAX23974.1 .
    FJ980275 mRNA. Translation: ACR56328.1 .
    DQ079590 mRNA. Translation: AAZ30918.1 .
    AC024558 Genomic DNA. No translation available.
    AC073439 Genomic DNA. No translation available.
    AK092101 mRNA. Translation: BAC03805.1 . Different initiation.
    BC002940 mRNA. Translation: AAH02940.2 .
    BC012729 mRNA. Translation: AAH12729.2 .
    BC073859 mRNA. Translation: AAH73859.1 .
    CCDSi CCDS43145.1. [Q2QGD7-1 ]
    CCDS43146.1. [Q2QGD7-2 ]
    RefSeqi NP_001035743.1. NM_001040653.3. [Q2QGD7-2 ]
    NP_079388.3. NM_025112.4. [Q2QGD7-1 ]
    UniGenei Hs.440049.
    Hs.711046.

    3D structure databases

    ProteinModelPortali Q2QGD7.
    SMRi Q2QGD7. Positions 167-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122653. 10 interactions.
    IntActi Q2QGD7. 9 interactions.
    MINTi MINT-8247508.
    STRINGi 9606.ENSP00000374359.

    PTM databases

    PhosphoSitei Q2QGD7.

    Polymorphism databases

    DMDMi 296453026.

    Proteomic databases

    MaxQBi Q2QGD7.
    PaxDbi Q2QGD7.
    PRIDEi Q2QGD7.

    Protocols and materials databases

    DNASUi 79364.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336332 ; ENSP00000337694 ; ENSG00000070476 . [Q2QGD7-2 ]
    ENST00000389709 ; ENSP00000374359 ; ENSG00000070476 . [Q2QGD7-1 ]
    GeneIDi 79364.
    KEGGi hsa:79364.
    UCSCi uc003eiv.3. human. [Q2QGD7-1 ]
    uc003eix.2. human. [Q2QGD7-2 ]

    Organism-specific databases

    CTDi 79364.
    GeneCardsi GC03M126156.
    HGNCi HGNC:28160. ZXDC.
    HPAi HPA049593.
    neXtProti NX_Q2QGD7.
    PharmGKBi PA142670466.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013019.
    HOVERGENi HBG002277.
    InParanoidi Q2QGD7.
    OMAi PLEGCGW.
    OrthoDBi EOG776SPF.
    PhylomeDBi Q2QGD7.
    TreeFami TF330996.

    Miscellaneous databases

    ChiTaRSi ZXDC. human.
    GenomeRNAii 79364.
    NextBioi 35482958.
    PROi Q2QGD7.

    Gene expression databases

    ArrayExpressi Q2QGD7.
    Bgeei Q2QGD7.
    CleanExi HS_ZXDC.
    Genevestigatori Q2QGD7.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription."
      Al-Kandari W., Jambunathan S., Navalgund V., Koneni R., Freer M., Parimi N., Mudhasani R., Fontes J.D.
      Mol. Immunol. 44:311-321(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CIITA, TISSUE SPECIFICITY.
    2. "An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription."
      Aleksandrova A., Galkin O., Koneni R., Fontes J.D.
      Mol. Cell. Biochem. 337:1-7(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT LEU-562.
    3. "Cloning and characterization of the ZXDL gene which encodes a putative zinc finger protein."
      Tang W.W., Tang Z.H., Yu L.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-858 (ISOFORM 2).
      Tissue: Teratocarcinoma.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-858 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-710 (ISOFORM 2).
      Tissue: Placenta, Skin and Testis.
    7. "Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain."
      Jambunathan S., Fontes J.D.
      Biol. Chem. 388:965-972(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION AT LYS-660, FUNCTION.
    8. "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription."
      Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D.
      J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDA AND CIITA.

    Entry informationi

    Entry nameiZXDC_HUMAN
    AccessioniPrimary (citable) accession number: Q2QGD7
    Secondary accession number(s): C5J0H9
    , Q6DKI8, Q7L3L1, Q8NAU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3