Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2QGD7

- ZXDC_HUMAN

UniProt

Q2QGD7 - ZXDC_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein ZXDC

Gene

ZXDC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 32125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38225C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41225C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44225C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47626C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. C2H2 zinc finger domain binding Source: UniProtKB
  2. LRR domain binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. nucleic acid binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZXDC
Alternative name(s):
ZXD-like zinc finger protein
Gene namesi
Name:ZXDC
Synonyms:ZXDL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28160. ZXDC.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Zinc finger protein ZXDCPRO_0000292803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki660 – 660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ2QGD7.
PaxDbiQ2QGD7.
PRIDEiQ2QGD7.

PTM databases

PhosphoSiteiQ2QGD7.

Expressioni

Tissue specificityi

Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.1 Publication

Gene expression databases

BgeeiQ2QGD7.
CleanExiHS_ZXDC.
ExpressionAtlasiQ2QGD7. baseline and differential.
GenevestigatoriQ2QGD7.

Organism-specific databases

HPAiHPA049593.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDA and CIITA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CIITAP330766EBI-1538838,EBI-1538819
ZXDAP981685EBI-1538838,EBI-1538980

Protein-protein interaction databases

BioGridi122653. 11 interactions.
IntActiQ2QGD7. 9 interactions.
MINTiMINT-8247508.
STRINGi9606.ENSP00000374359.

Structurei

3D structure databases

ProteinModelPortaliQ2QGD7.
SMRiQ2QGD7. Positions 167-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni579 – 688110Required for transcriptional activationAdd
BLAST
Regioni781 – 85878Interaction with CIITAAdd
BLAST

Sequence similaritiesi

Belongs to the ZXD family.Curated
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 32125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38225C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41225C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44225C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47626C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120526.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiQ2QGD7.
OMAiPLEGCGW.
OrthoDBiEOG776SPF.
PhylomeDBiQ2QGD7.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2QGD7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLPALLPAP TARGGQHGGG PGPLRRAPAP LGASPARRRL LLVRGPEDGG
60 70 80 90 100
PGARPGEASG PSPPPAEDDS DGDSFLVLLE VPHGGAAAEA AGSQEAEPGS
110 120 130 140 150
RVNLASRPEQ GPSGPAAPPG PGVAPAGAVT ISSQDLLVRL DRGVLALSAP
160 170 180 190 200
PGPATAGAAA PRRAPQASGP STPGYRCPEP QCALAFAKKH QLKVHLLTHG
210 220 230 240 250
GGQGRRPFKC PLEGCGWAFT TSYKLKRHLQ SHDKLRPFGC PVGGCGKKFT
260 270 280 290 300
TVYNLKAHMK GHEQESLFKC EVCAERFPTH AKLSSHQRSH FEPERPYKCD
310 320 330 340 350
FPGCEKTFIT VSALFSHNRA HFREQELFSC SFPGCSKQYD KACRLKIHLR
360 370 380 390 400
SHTGERPFIC DSDSCGWTFT SMSKLLRHRR KHDDDRRFTC PVEGCGKSFT
410 420 430 440 450
RAEHLKGHSI THLGTKPFEC PVEGCCARFS ARSSLYIHSK KHVQDVGAPK
460 470 480 490 500
SRCPVSTCNR LFTSKHSMKA HMVRQHSRRQ DLLPQLEAPS SLTPSSELSS
510 520 530 540 550
PGQSELTNMD LAALFSDTPA NASGSAGGSD EALNSGILTI DVTSVSSSLG
560 570 580 590 600
GNLPANNSSL GPMEPLVLVA HSDIPPSLDS PLVLGTAATV LQQGSFSVDD
610 620 630 640 650
VQTVSAGALG CLVALPMKNL SDDPLALTSN SNLAAHITTP TSSSTPRENA
660 670 680 690 700
SVPELLAPIK VEPDSPSRPG AVGQQEGSHG LPQSTLPSPA EQHGAQDTEL
710 720 730 740 750
SAGTGNFYLE SGGSARTDYR AIQLAKEKKQ RGAGSNAGAS QSTQRKIKEG
760 770 780 790 800
KMSPPHFHAS QNSWLCGSLV VPSGGRPGPA PAAGVQCGAQ GVQVQLVQDD
810 820 830 840 850
PSGEGVLPSA RGPATFLPFL TVDLPVYVLQ EVLPSSGGPA GPEATQFPGS

TINLQDLQ
Length:858
Mass (Da):89,988
Last modified:May 18, 2010 - v2
Checksum:i8C35F5685CF1E695
GO
Isoform 2 (identifier: Q2QGD7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-710: E → V
     711-858: Missing.

Show »
Length:710
Mass (Da):74,817
Checksum:i0B2CE6ADCC39E7FD
GO
Isoform 3 (identifier: Q2QGD7-3) [UniParc]FASTAAdd to Basket

Also known as: ZXDC2

The sequence of this isoform differs from the canonical sequence as follows:
     1-258: Missing.
     710-710: E → V
     711-858: Missing.

Note: Doesn't interact with CIITA. Represses MHC class II transcription possibly via dominant-negative association with isoform 1.

Show »
Length:452
Mass (Da):48,685
Checksum:iDCFED7A4DF0B2129
GO

Sequence cautioni

The sequence BAC03805.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181P → A in AAX23974. (PubMed:16600381)Curated
Sequence conflicti118 – 1181P → A in AAZ30918. 1 PublicationCurated
Sequence conflicti683 – 6831Q → H in AAH73859. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti562 – 5621P → L.1 Publication
Corresponds to variant rs16837497 [ dbSNP | Ensembl ].
VAR_057464

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 258258Missing in isoform 3. 1 PublicationVSP_047464Add
BLAST
Alternative sequencei710 – 7101E → V in isoform 2 and isoform 3. 3 PublicationsVSP_026437
Alternative sequencei711 – 858148Missing in isoform 2 and isoform 3. 3 PublicationsVSP_026438Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY936556 mRNA. Translation: AAX23974.1.
FJ980275 mRNA. Translation: ACR56328.1.
DQ079590 mRNA. Translation: AAZ30918.1.
AC024558 Genomic DNA. No translation available.
AC073439 Genomic DNA. No translation available.
AK092101 mRNA. Translation: BAC03805.1. Different initiation.
BC002940 mRNA. Translation: AAH02940.2.
BC012729 mRNA. Translation: AAH12729.2.
BC073859 mRNA. Translation: AAH73859.1.
CCDSiCCDS43145.1. [Q2QGD7-1]
CCDS43146.1. [Q2QGD7-2]
RefSeqiNP_001035743.1. NM_001040653.3. [Q2QGD7-2]
NP_079388.3. NM_025112.4. [Q2QGD7-1]
UniGeneiHs.440049.
Hs.711046.

Genome annotation databases

EnsembliENST00000336332; ENSP00000337694; ENSG00000070476. [Q2QGD7-2]
ENST00000389709; ENSP00000374359; ENSG00000070476. [Q2QGD7-1]
GeneIDi79364.
KEGGihsa:79364.
UCSCiuc003eiv.3. human. [Q2QGD7-1]
uc003eix.2. human. [Q2QGD7-2]

Polymorphism databases

DMDMi296453026.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY936556 mRNA. Translation: AAX23974.1 .
FJ980275 mRNA. Translation: ACR56328.1 .
DQ079590 mRNA. Translation: AAZ30918.1 .
AC024558 Genomic DNA. No translation available.
AC073439 Genomic DNA. No translation available.
AK092101 mRNA. Translation: BAC03805.1 . Different initiation.
BC002940 mRNA. Translation: AAH02940.2 .
BC012729 mRNA. Translation: AAH12729.2 .
BC073859 mRNA. Translation: AAH73859.1 .
CCDSi CCDS43145.1. [Q2QGD7-1 ]
CCDS43146.1. [Q2QGD7-2 ]
RefSeqi NP_001035743.1. NM_001040653.3. [Q2QGD7-2 ]
NP_079388.3. NM_025112.4. [Q2QGD7-1 ]
UniGenei Hs.440049.
Hs.711046.

3D structure databases

ProteinModelPortali Q2QGD7.
SMRi Q2QGD7. Positions 167-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122653. 11 interactions.
IntActi Q2QGD7. 9 interactions.
MINTi MINT-8247508.
STRINGi 9606.ENSP00000374359.

PTM databases

PhosphoSitei Q2QGD7.

Polymorphism databases

DMDMi 296453026.

Proteomic databases

MaxQBi Q2QGD7.
PaxDbi Q2QGD7.
PRIDEi Q2QGD7.

Protocols and materials databases

DNASUi 79364.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336332 ; ENSP00000337694 ; ENSG00000070476 . [Q2QGD7-2 ]
ENST00000389709 ; ENSP00000374359 ; ENSG00000070476 . [Q2QGD7-1 ]
GeneIDi 79364.
KEGGi hsa:79364.
UCSCi uc003eiv.3. human. [Q2QGD7-1 ]
uc003eix.2. human. [Q2QGD7-2 ]

Organism-specific databases

CTDi 79364.
GeneCardsi GC03M126156.
HGNCi HGNC:28160. ZXDC.
HPAi HPA049593.
neXtProti NX_Q2QGD7.
PharmGKBi PA142670466.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120526.
HOGENOMi HOG000013019.
HOVERGENi HBG002277.
InParanoidi Q2QGD7.
OMAi PLEGCGW.
OrthoDBi EOG776SPF.
PhylomeDBi Q2QGD7.
TreeFami TF330996.

Miscellaneous databases

ChiTaRSi ZXDC. human.
GenomeRNAii 79364.
NextBioi 35482958.
PROi Q2QGD7.

Gene expression databases

Bgeei Q2QGD7.
CleanExi HS_ZXDC.
ExpressionAtlasi Q2QGD7. baseline and differential.
Genevestigatori Q2QGD7.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 3 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription."
    Al-Kandari W., Jambunathan S., Navalgund V., Koneni R., Freer M., Parimi N., Mudhasani R., Fontes J.D.
    Mol. Immunol. 44:311-321(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CIITA, TISSUE SPECIFICITY.
  2. "An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription."
    Aleksandrova A., Galkin O., Koneni R., Fontes J.D.
    Mol. Cell. Biochem. 337:1-7(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT LEU-562.
  3. "Cloning and characterization of the ZXDL gene which encodes a putative zinc finger protein."
    Tang W.W., Tang Z.H., Yu L.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-858 (ISOFORM 2).
    Tissue: Teratocarcinoma.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-858 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-710 (ISOFORM 2).
    Tissue: Placenta, Skin and Testis.
  7. "Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain."
    Jambunathan S., Fontes J.D.
    Biol. Chem. 388:965-972(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-660, FUNCTION.
  8. "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription."
    Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D.
    J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDA AND CIITA.

Entry informationi

Entry nameiZXDC_HUMAN
AccessioniPrimary (citable) accession number: Q2QGD7
Secondary accession number(s): C5J0H9
, Q6DKI8, Q7L3L1, Q8NAU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3