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Protein

Deoxyribonuclease-1-like 1

Gene

Dnase1l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113By similarity1
Active sitei164By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-1-like 1 (EC:3.1.21.-)
Alternative name(s):
DNase X
Deoxyribonuclease I-like 1
Short name:
DNase I-like 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1359588. Dnase1l1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023103436 – 312Deoxyribonuclease-1-like 1Add BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi203 ↔ 240Essential for enzymatic activityBy similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2QDE7.
PRIDEiQ2QDE7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037242.
ExpressionAtlasiQ2QDE7. differential.
GenevisibleiQ2QDE7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053125.

Structurei

3D structure databases

ProteinModelPortaliQ2QDE7.
SMRiQ2QDE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH3K. Eukaryota.
ENOG410Z4MV. LUCA.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiQ2QDE7.
KOiK11995.
OMAiCASLTKK.
OrthoDBiEOG091G0I0B.
PhylomeDBiQ2QDE7.
TreeFamiTF329541.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiView protein in InterPro
IPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
PfamiView protein in Pfam
PF03372. Exo_endo_phos. 1 hit.
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiView protein in SMART
SM00476. DNaseIc. 1 hit.
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiView protein in PROSITE
PS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2QDE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGQPVFPR RVPDAYIAMR GLVVASLLIL LVGGTDAFRI CAFNAHRLTL
60 70 80 90 100
TKVIKESVMD TLVQILARCD IMVLQEVVDS SQNTVLFLLQ KLQSSKSYSF
110 120 130 140 150
LNSSLLGRST YKEKYVYIYR SDKTQVLNFY QYNDTEDIFA REPFVAQFTL
160 170 180 190 200
PSKILPSVVL VPLHTTPKDV EKELNALYDV FLDVSQRWQN ENVILLGDFN
210 220 230 240 250
ADCASLAKKR LNSLLLRTKA GFHWVIPDGE DTTVRASTNC TYDRIVMHGQ
260 270 280 290 300
GCQKLLKAAA TFDFPRRFQL TEEEALRVSD HYPVEVELNK AAQGIPPHCL
310
STLLLLSLSQ LG
Length:312
Mass (Da):35,182
Last modified:January 24, 2006 - v1
Checksum:i73049972C0A8F9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116785 mRNA. Translation: AAZ94278.1.
RefSeqiNP_001014245.2. NM_001014223.2.
UniGeneiRn.163455.

Genome annotation databases

EnsembliENSRNOT00000083203; ENSRNOP00000073157; ENSRNOG00000055641.
GeneIDi363522.
KEGGirno:363522.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDNSL1_RAT
AccessioniPrimary (citable) accession number: Q2QDE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: July 5, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families