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Protein

Ribulose-phosphate 3-epimerase-like protein 1

Gene

RPEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Miscellaneous

According to some authors, RPEL1 is a RPE retrogene on chromosome 2 which is likely to be functional.1 Publication

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Fe2+By similarity, Mn2+By similarity, Zn2+By similarity, Co2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Fe2+, and probably also with Mn2+, Zn2+ and Co2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Metal bindingi35Divalent metal cationBy similarity1
Active sitei37Proton acceptorBy similarity1
Metal bindingi37Divalent metal cationBy similarity1
Metal bindingi70Divalent metal cationBy similarity1
Binding sitei70SubstrateBy similarity1
Active sitei175Proton donorBy similarity1
Metal bindingi175Divalent metal cationBy similarity1
Binding sitei177Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase-like protein 1 (EC:5.1.3.1)
Alternative name(s):
Ribulose-5-phosphate-3-epimerase-like protein 1
Gene namesi
Name:RPEL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000235376.5.
HGNCiHGNC:45241. RPEL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000235376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004255642 – 228Ribulose-phosphate 3-epimerase-like protein 1Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ2QD12.
MaxQBiQ2QD12.
PaxDbiQ2QD12.
PeptideAtlasiQ2QD12.
PRIDEiQ2QD12.

Expressioni

Gene expression databases

BgeeiENSG00000235376.
GenevisibleiQ2QD12. HS.

Organism-specific databases

HPAiHPA036498.
HPA036499.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2QD12.
SMRiQ2QD12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 149Substrate bindingBy similarity4
Regioni197 – 198Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3111. Eukaryota.
COG0036. LUCA.
GeneTreeiENSGT00390000001447.
HOVERGENiHBG044821.
KOiK01783.
OMAiISVHYES.
OrthoDBiEOG091G0JMQ.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiView protein in Pfam
PF00834. Ribul_P_3_epim. 1 hit.
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiView protein in PROSITE
PS01085. RIBUL_P_3_EPIMER_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2QD12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGCKIGPS ILNSDLANLG AKCLQMLDSG ADYLHLDVMD GHFVPNITFG
60 70 80 90 100
HPVVESLRKQ LGQDPFFDMH MMVSKPEQWV KPMAVAEANQ YTFHLEATEN
110 120 130 140 150
PGTLIKDIRE NGMKVGLAIK PGTSVEYLAP WANQIDMALV MTVEPGFGEQ
160 170 180 190 200
KFMEDMMPKV HWLRTQFPSL DIEGDGGVGS DTVHKCAEAG ANMTVSGSAI
210 220
MRSEDPRSVI NLLRNICSEA AQKRSLDR
Length:228
Mass (Da):25,023
Last modified:January 24, 2006 - v1
Checksum:i231D8799E36AD588
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ120706 Genomic DNA. Translation: ABC40667.1.
AL360001 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49655.1.
BC137242 mRNA. Translation: AAI37243.1.
BC137243 mRNA. Translation: AAI37244.1.
BC157829 mRNA. Translation: AAI57830.1.
BC157875 mRNA. Translation: AAI57876.1.
BC171806 mRNA. Translation: AAI71806.1.
BC171885 mRNA. Translation: AAI71885.1.
CCDSiCCDS65929.1.
RefSeqiNP_001137381.1. NM_001143909.1.
UniGeneiHs.458437.

Genome annotation databases

EnsembliENST00000441178; ENSP00000476672; ENSG00000235376.
GeneIDi729020.
KEGGihsa:729020.
UCSCiuc009xxi.2. human.

Similar proteinsi

Entry informationi

Entry nameiRPEL1_HUMAN
AccessioniPrimary (citable) accession number: Q2QD12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: January 24, 2006
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families