ID   Q2QBT8_GIAIN            Unreviewed;       248 AA.
AC   Q2QBT8; A8BJ73; C6LVW8;
DT   24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   24-JAN-2006, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Putative 14-3-3 domain protein {ECO:0000313|EMBL:ESU39602.1};
GN   ORFNames=DHA2_6430 {ECO:0000313|EMBL:ESU39602.1}, GSB_6430
GN   {ECO:0000313|EMBL:ESU43177.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU39602.1, ECO:0000313|Proteomes:UP000018320};
RN   [1] {ECO:0000313|Proteomes:UP000018040, ECO:0000313|Proteomes:UP000018320}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DH {ECO:0000313|Proteomes:UP000018320}, and GS
RC   {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU39602.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DH {ECO:0000313|EMBL:ESU39602.1}, and GS
RC   {ECO:0000313|EMBL:ESU43177.1};
RA   Feng W., Liu Z., Li S., Tang W., Yang J.;
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000018040, ECO:0000313|Proteomes:UP000018320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH {ECO:0000313|EMBL:ESU39602.1,
RC   ECO:0000313|Proteomes:UP000018320}, and GS
RC   {ECO:0000313|EMBL:ESU43177.1, ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- SIMILARITY: Belongs to the 14-3-3 family.
CC       {ECO:0000256|ARBA:ARBA00006141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU39602.1}.
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DR   EMBL; AHGT01000002; ESU39602.1; -; Genomic_DNA.
DR   EMBL; AHHH01000057; ESU43177.1; -; Genomic_DNA.
DR   PDBsum; 4F7R; -.
DR   PDBsum; 5BY9; -.
DR   AlphaFoldDB; Q2QBT8; -.
DR   SMR; Q2QBT8; -.
DR   EnsemblProtists; ESU39602; ESU39602; DHA2_6430.
DR   EnsemblProtists; ESU43177; ESU43177; GSB_6430.
DR   VEuPathDB; GiardiaDB:DHA2_6430; -.
DR   VEuPathDB; GiardiaDB:GL50581_2925; -.
DR   VEuPathDB; GiardiaDB:GL50803_006430; -.
DR   VEuPathDB; GiardiaDB:QR46_1908; -.
DR   eggNOG; KOG0841; Eukaryota.
DR   OMA; KGCQLAR; -.
DR   OrthoDB; 920089at2759; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   Proteomes; UP000018320; Unassembled WGS sequence.
DR   CDD; cd08774; 14-3-3; 1.
DR   Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR   InterPro; IPR000308; 14-3-3.
DR   InterPro; IPR023409; 14-3-3_CS.
DR   InterPro; IPR036815; 14-3-3_dom_sf.
DR   InterPro; IPR023410; 14-3-3_domain.
DR   PANTHER; PTHR18860; 14-3-3 PROTEIN; 1.
DR   PANTHER; PTHR18860:SF160; 14-3-3 PROTEIN ZETA; 1.
DR   Pfam; PF00244; 14-3-3; 1.
DR   PIRSF; PIRSF000868; 14-3-3; 1.
DR   PRINTS; PR00305; 1433ZETA.
DR   SMART; SM00101; 14_3_3; 1.
DR   SUPFAM; SSF48445; 14-3-3 protein; 1.
DR   PROSITE; PS00796; 1433_1; 1.
PE   3: Inferred from homology;
FT   DOMAIN          7..248
FT                   /note="14-3-3"
FT                   /evidence="ECO:0000259|SMART:SM00101"
FT   SITE            60
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
FT   SITE            135
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
SQ   SEQUENCE   248 AA;  28576 MW;  83E4D80EDED75B14 CRC64;
     MAEAFTREDY VFMAQLNENA ERYDEMVETM RKISGMEGEL SDKERNLLSV AYKNVIGPRR
     AAWRIVSSIE AKEKGRQKPN AKRIEQIRVY RQKIEKELSD ICNDILKLLQ EQFVPRSTNA
     DAKVFYYKMQ GDYYRYLAEY SSGEDKEKIA GSALNAYNSA FEISQQLPPT HPIRLGLALN
     FSVFYYEILA SPDRACELAR KAFDAAITDL DKLTEESYKD STLIMQLLRD NLNLWVTDSA
     GDDNAEEK
//