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Protein
Submitted name:

14-3-3 protein

Gene

DHA2_6430

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601Sulfate 2Combined sources
Binding sitei76 – 761Sulfate 3Combined sources
Binding sitei91 – 911Sulfate 6Combined sources
Binding sitei128 – 1281Sulfate 1Combined sources
Binding sitei128 – 1281Sulfate 7Combined sources
Binding sitei132 – 1321Sulfate 1Combined sources
Binding sitei180 – 1801Sulfate 1Combined sources
Binding sitei180 – 1801Sulfate 7Combined sources

Names & Taxonomyi

Protein namesi
Submitted name:
14-3-3 proteinImported
Submitted name:
Putative 14-3-3 domain proteinImported
Gene namesi
ORF Names:DHA2_6430Imported, GSB_6430Imported
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
ProteomesiUP000018040 Componenti: Unassembled WGS sequence UP000018320 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F7RX-ray3.20A/B/C/D1-248[»]
ProteinModelPortaliQ2QBT8.
SMRiQ2QBT8. Positions 7-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 783Sulfate 4 bindingCombined sources
Regioni88 – 914Sulfate 5 bindingCombined sources
Regioni135 – 1362Sulfate 2 bindingCombined sources

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2QBT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAFTREDY VFMAQLNENA ERYDEMVETM RKISGMEGEL SDKERNLLSV
60 70 80 90 100
AYKNVIGPRR AAWRIVSSIE AKEKGRQKPN AKRIEQIRVY RQKIEKELSD
110 120 130 140 150
ICNDILKLLQ EQFVPRSTNA DAKVFYYKMQ GDYYRYLAEY SSGEDKEKIA
160 170 180 190 200
GSALNAYNSA FEISQQLPPT HPIRLGLALN FSVFYYEILA SPDRACELAR
210 220 230 240
KAFDAAITDL DKLTEESYKD STLIMQLLRD NLNLWVTDSA GDDNAEEK
Length:248
Mass (Da):28,576
Last modified:January 23, 2006 - v1
Checksum:i83E4D80EDED75B14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ146480 Genomic DNA. Translation: AAZ91664.1.
AHGT01000002 Genomic DNA. Translation: ESU39602.1.
AHHH01000057 Genomic DNA. Translation: ESU43177.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ146480 Genomic DNA. Translation: AAZ91664.1.
AHGT01000002 Genomic DNA. Translation: ESU39602.1.
AHHH01000057 Genomic DNA. Translation: ESU43177.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F7RX-ray3.20A/B/C/D1-248[»]
ProteinModelPortaliQ2QBT8.
SMRiQ2QBT8. Positions 7-235.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail."
    Lalle M., Salzano A.M., Crescenzi M., Pozio E.
    J. Biol. Chem. 281:5137-5148(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WB-C6Imported.
  2. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
    Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DHImported and GSImported.
  3. "The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference."
    Fiorillo A., di Marino D., Bertuccini L., Via A., Pozio E., Camerini S., Ilari A., Lalle M.
    PLoS ONE 9:e92902-e92902(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).

Entry informationi

Entry nameiQ2QBT8_GIAIN
AccessioniPrimary (citable) accession number: Q2QBT8
Secondary accession number(s): A8BJ73, C6LVW8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2006
Last sequence update: January 23, 2006
Last modified: March 31, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.