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Q2QBT8

- Q2QBT8_GIAIN

UniProt

Q2QBT8 - Q2QBT8_GIAIN

Protein
Submitted name:

14-3-3 protein

Gene

DHA2_6430

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601Sulfate 2Imported
    Binding sitei76 – 761Sulfate 3Imported
    Binding sitei91 – 911Sulfate 6Imported
    Binding sitei128 – 1281Sulfate 1Imported
    Binding sitei128 – 1281Sulfate 7Imported
    Binding sitei132 – 1321Sulfate 1Imported
    Binding sitei180 – 1801Sulfate 1Imported
    Binding sitei180 – 1801Sulfate 7Imported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    14-3-3 proteinImported
    Submitted name:
    Putative 14-3-3 domain proteinImported
    Gene namesi
    ORF Names:DHA2_6430Imported, GSB_6430Imported
    OrganismiGiardia intestinalis (Giardia lamblia)Imported
    Taxonomic identifieri5741 [NCBI]
    Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
    ProteomesiUP000018040: Unassembled WGS sequence

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F7RX-ray3.20A/B/C/D1-248[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 783Sulfate 4 bindingImported
    Regioni88 – 914Sulfate 5 bindingImported
    Regioni135 – 1362Sulfate 2 bindingImported

    Family and domain databases

    Gene3Di1.20.190.20. 1 hit.
    InterProiIPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view]
    PANTHERiPTHR18860. PTHR18860. 1 hit.
    PfamiPF00244. 14-3-3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000868. 14-3-3. 1 hit.
    PRINTSiPR00305. 1433ZETA.
    SMARTiSM00101. 14_3_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48445. SSF48445. 1 hit.
    PROSITEiPS00796. 1433_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2QBT8-1 [UniParc]FASTAAdd to Basket

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    MAEAFTREDY VFMAQLNENA ERYDEMVETM RKISGMEGEL SDKERNLLSV    50
    AYKNVIGPRR AAWRIVSSIE AKEKGRQKPN AKRIEQIRVY RQKIEKELSD 100
    ICNDILKLLQ EQFVPRSTNA DAKVFYYKMQ GDYYRYLAEY SSGEDKEKIA 150
    GSALNAYNSA FEISQQLPPT HPIRLGLALN FSVFYYEILA SPDRACELAR 200
    KAFDAAITDL DKLTEESYKD STLIMQLLRD NLNLWVTDSA GDDNAEEK 248
    Length:248
    Mass (Da):28,576
    Last modified:January 24, 2006 - v1
    Checksum:i83E4D80EDED75B14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ146480 Genomic DNA. Translation: AAZ91664.1.
    AHGT01000002 Genomic DNA. Translation: ESU39602.1.
    AHHH01000057 Genomic DNA. Translation: ESU43177.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ146480 Genomic DNA. Translation: AAZ91664.1 .
    AHGT01000002 Genomic DNA. Translation: ESU39602.1 .
    AHHH01000057 Genomic DNA. Translation: ESU43177.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F7R X-ray 3.20 A/B/C/D 1-248 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.190.20. 1 hit.
    InterProi IPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view ]
    PANTHERi PTHR18860. PTHR18860. 1 hit.
    Pfami PF00244. 14-3-3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000868. 14-3-3. 1 hit.
    PRINTSi PR00305. 1433ZETA.
    SMARTi SM00101. 14_3_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48445. SSF48445. 1 hit.
    PROSITEi PS00796. 1433_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail."
      Lalle M., Salzano A.M., Crescenzi M., Pozio E.
      J. Biol. Chem. 281:5137-5148(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WB-C6Imported.
    2. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
      Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DHImported and GSImported.
    3. "The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference."
      Fiorillo A., di Marino D., Bertuccini L., Via A., Pozio E., Camerini S., Ilari A., Lalle M.
      PLoS ONE 9:e92902-e92902(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).

    Entry informationi

    Entry nameiQ2QBT8_GIAIN
    AccessioniPrimary (citable) accession number: Q2QBT8
    Secondary accession number(s): A8BJ73, C6LVW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3