Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase
  2. 6-phosphogluconolactonase (PGLS)
  3. 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:G6PDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ2Q9B7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000377192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 170170G6PD_NInterPro annotationAdd
BLAST
Domaini172 – 463292G6PD_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
HOVERGENiHBG000856.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2Q9B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDLAKKKIYP TIWWLFRDGL LPENTFIMGY ARSRLTVADI RKQSEPFFKA
60 70 80 90 100
TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMDALHL GSQANRLFYL
110 120 130 140 150
ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL
160 170 180 190 200
FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP
210 220 230 240 250
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK
260 270 280 290 300
VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV
310 320 330 340 350
VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL
360 370 380 390 400
VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL
410 420 430 440 450
ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT
460 470
EADELMKRVG FQYEGTYKWV NPHKL
Length:475
Mass (Da):54,857
Last modified:January 24, 2006 - v1
Checksum:i9F3A907FD3D6754A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ173623 Genomic DNA. Translation: ABC25886.1.
DQ173624 Genomic DNA. Translation: ABC25891.1.
DQ173625 Genomic DNA. Translation: ABC25896.1.
DQ173626 Genomic DNA. Translation: ABC25901.1.
DQ173627 Genomic DNA. Translation: ABC25906.1.
DQ173628 Genomic DNA. Translation: ABC25911.1.
DQ173629 Genomic DNA. Translation: ABC25916.1.
DQ173630 Genomic DNA. Translation: ABC25921.1.
DQ173631 Genomic DNA. Translation: ABC25926.1.
DQ173632 Genomic DNA. Translation: ABC25931.1.
DQ173633 Genomic DNA. Translation: ABC25936.1.
DQ173634 Genomic DNA. Translation: ABC25941.1.
DQ173635 Genomic DNA. Translation: ABC25946.1.
DQ173636 Genomic DNA. Translation: ABC25951.1.
DQ173637 Genomic DNA. Translation: ABC25956.1.
DQ173638 Genomic DNA. Translation: ABC25961.1.
DQ173639 Genomic DNA. Translation: ABC25966.1.
DQ173640 Genomic DNA. Translation: ABC25971.1.
DQ173641 Genomic DNA. Translation: ABC25976.1.
DQ173642 Genomic DNA. Translation: ABC25981.1.
UniGeneiHs.461047.
Hs.684904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ173623 Genomic DNA. Translation: ABC25886.1.
DQ173624 Genomic DNA. Translation: ABC25891.1.
DQ173625 Genomic DNA. Translation: ABC25896.1.
DQ173626 Genomic DNA. Translation: ABC25901.1.
DQ173627 Genomic DNA. Translation: ABC25906.1.
DQ173628 Genomic DNA. Translation: ABC25911.1.
DQ173629 Genomic DNA. Translation: ABC25916.1.
DQ173630 Genomic DNA. Translation: ABC25921.1.
DQ173631 Genomic DNA. Translation: ABC25926.1.
DQ173632 Genomic DNA. Translation: ABC25931.1.
DQ173633 Genomic DNA. Translation: ABC25936.1.
DQ173634 Genomic DNA. Translation: ABC25941.1.
DQ173635 Genomic DNA. Translation: ABC25946.1.
DQ173636 Genomic DNA. Translation: ABC25951.1.
DQ173637 Genomic DNA. Translation: ABC25956.1.
DQ173638 Genomic DNA. Translation: ABC25961.1.
DQ173639 Genomic DNA. Translation: ABC25966.1.
DQ173640 Genomic DNA. Translation: ABC25971.1.
DQ173641 Genomic DNA. Translation: ABC25976.1.
DQ173642 Genomic DNA. Translation: ABC25981.1.
UniGeneiHs.461047.
Hs.684904.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000377192.

Proteomic databases

PeptideAtlasiQ2Q9B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
HOVERGENiHBG000856.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Miscellaneous databases

ChiTaRSiG6PD. human.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2Q9B7_HUMAN
AccessioniPrimary (citable) accession number: Q2Q9B7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.