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Q2Q452

- Q2Q452_9EURY

UniProt

Q2Q452 - Q2Q452_9EURY

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Protein

DNA ligase

Gene

lig

Organism
Thermococcus onnurineus
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATPUniRule annotation
Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
Binding sitei257 – 2571ATPUniRule annotation
Binding sitei272 – 2721ATPUniRule annotation
Binding sitei302 – 3021ATPUniRule annotation
Binding sitei342 – 3421ATPUniRule annotation
Binding sitei417 – 4171ATPUniRule annotation
Binding sitei423 – 4231ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.5.1.1. 289156.
6.5.1.2. 289156.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
OrganismiThermococcus onnurineusImported
Taxonomic identifieri342948 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Structurei

3D structure databases

ProteinModelPortaliQ2Q452.
SMRiQ2Q452. Positions 4-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2Q452-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDMKYTELS DLYRRLEKTT LKTLKTKFVA DFLKKTPDEL LEVVPYLILG
60 70 80 90 100
KVFPDWDERE LGVGEKLLIK AVSMATGVQE REIENSVKDT GDLGESVALA
110 120 130 140 150
LKKKKQKSFF SQPLTIKRVY QTFIKIAEAS GEGSQDRKLK YLANIFMDAQ
160 170 180 190 200
PEEGKYIART VLGMMRTGVA EGILRDAIAE AFKVKAELVE RAYMLTSDFG
210 220 230 240 250
YVAKVAKLEG NDGLGKVHIQ IGKPIRPMLA QNAASVKEAL LEMGAEAAFE
260 270 280 290 300
IKYDGARVQV HKDGDRVVIY SRRLENVTRS IPEVVDAIKA SIKSEKAIVE
310 320 330 340 350
GELVAVGEGG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDVLYVDGE
360 370 380 390 400
PLIDTPFRER RAKLEEIVEE GEKLKLAQQL VTKKVEEAEE FYKKALELGH
410 420 430 440 450
EGLMAKRLDS VYEPGNRGKK WLKIKPTMED LDLVIIGAEW GEGRRAHLLG
460 470 480 490 500
SFLVAAYDPH SGEFVPVGKV GSGFTDEDLV EFTKMLKPLI IGGEGKFVEI
510 520 530 540 550
EPKVVIQVTY QEIQKSPKYR SGFALRFPRY VALREDKSPE EADTIERIAQ
560
LYEFQERFKA KK
Length:562
Mass (Da):63,655
Last modified:January 24, 2006 - v1
Checksum:iA54BDEB51585437D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223722 Genomic DNA. Translation: ABC11973.1.
RefSeqiYP_002307902.1. NC_011529.1.

Genome annotation databases

GeneIDi7018552.
KEGGiton:TON_1515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223722 Genomic DNA. Translation: ABC11973.1 .
RefSeqi YP_002307902.1. NC_011529.1.

3D structure databases

ProteinModelPortali Q2Q452.
SMRi Q2Q452. Positions 4-561.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7018552.
KEGGi ton:TON_1515.

Phylogenomic databases

KOi K10747.

Enzyme and pathway databases

BRENDAi 6.5.1.1. 289156.
6.5.1.2. 289156.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Overexpression and Characterization of a DNA ligase from the Hyperthermophilic Archaeon Thermococcus sp. NA1."
    Kim Y.J., Lee H.S., Kang S.G., Kwon S.-T., Lee J.-H.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NA1Imported.

Entry informationi

Entry nameiQ2Q452_9EURY
AccessioniPrimary (citable) accession number: Q2Q452
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)