Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2Q452 (Q2Q452_9EURY) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase HAMAP-Rule MF_00407 RuleBase RU000617
EC=6.5.1.1 HAMAP-Rule MF_00407 RuleBase RU000617
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
OrganismThermococcus onnurineus EMBL ABC11973.1
Taxonomic identifier342948 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2521N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2501ATP By similarity HAMAP-Rule MF_00407
Binding site2571ATP By similarity HAMAP-Rule MF_00407
Binding site2721ATP By similarity HAMAP-Rule MF_00407
Binding site3021ATP By similarity HAMAP-Rule MF_00407
Binding site3421ATP By similarity HAMAP-Rule MF_00407
Binding site4171ATP By similarity HAMAP-Rule MF_00407
Binding site4231ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
Q2Q452 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: A54BDEB51585437D

FASTA56263,655
        10         20         30         40         50         60 
MGDMKYTELS DLYRRLEKTT LKTLKTKFVA DFLKKTPDEL LEVVPYLILG KVFPDWDERE 

        70         80         90        100        110        120 
LGVGEKLLIK AVSMATGVQE REIENSVKDT GDLGESVALA LKKKKQKSFF SQPLTIKRVY 

       130        140        150        160        170        180 
QTFIKIAEAS GEGSQDRKLK YLANIFMDAQ PEEGKYIART VLGMMRTGVA EGILRDAIAE 

       190        200        210        220        230        240 
AFKVKAELVE RAYMLTSDFG YVAKVAKLEG NDGLGKVHIQ IGKPIRPMLA QNAASVKEAL 

       250        260        270        280        290        300 
LEMGAEAAFE IKYDGARVQV HKDGDRVVIY SRRLENVTRS IPEVVDAIKA SIKSEKAIVE 

       310        320        330        340        350        360 
GELVAVGEGG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDVLYVDGE PLIDTPFRER 

       370        380        390        400        410        420 
RAKLEEIVEE GEKLKLAQQL VTKKVEEAEE FYKKALELGH EGLMAKRLDS VYEPGNRGKK 

       430        440        450        460        470        480 
WLKIKPTMED LDLVIIGAEW GEGRRAHLLG SFLVAAYDPH SGEFVPVGKV GSGFTDEDLV 

       490        500        510        520        530        540 
EFTKMLKPLI IGGEGKFVEI EPKVVIQVTY QEIQKSPKYR SGFALRFPRY VALREDKSPE 

       550        560 
EADTIERIAQ LYEFQERFKA KK

« Hide

References

[1]"Overexpression and Characterization of a DNA ligase from the Hyperthermophilic Archaeon Thermococcus sp. NA1."
Kim Y.J., Lee H.S., Kang S.G., Kwon S.-T., Lee J.-H.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NA1 EMBL ABC11973.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ223722 Genomic DNA. Translation: ABC11973.1.
RefSeqYP_002307902.1. NC_011529.1.

3D structure databases

ProteinModelPortalQ2Q452.
SMRQ2Q452. Positions 4-561.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7018552.
KEGGton:TON_1515.

Phylogenomic databases

KOK10747.
ProtClustDBPRK01109.

Enzyme and pathway databases

BRENDA6.5.1.1. 289156.
6.5.1.2. 289156.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2Q452_9EURY
AccessionPrimary (citable) accession number: Q2Q452
Entry history
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: March 6, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info