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Q2Q452

- Q2Q452_9EURY

UniProt

Q2Q452 - Q2Q452_9EURY

Protein

DNA ligase

Gene

lig

Organism
Thermococcus onnurineus
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei272 – 2721ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei417 – 4171ATPUniRule annotation
    Binding sitei423 – 4231ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.5.1.1. 289156.
    6.5.1.2. 289156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    OrganismiThermococcus onnurineusImported
    Taxonomic identifieri342948 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

    Structurei

    3D structure databases

    ProteinModelPortaliQ2Q452.
    SMRiQ2Q452. Positions 4-561.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2Q452-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDMKYTELS DLYRRLEKTT LKTLKTKFVA DFLKKTPDEL LEVVPYLILG    50
    KVFPDWDERE LGVGEKLLIK AVSMATGVQE REIENSVKDT GDLGESVALA 100
    LKKKKQKSFF SQPLTIKRVY QTFIKIAEAS GEGSQDRKLK YLANIFMDAQ 150
    PEEGKYIART VLGMMRTGVA EGILRDAIAE AFKVKAELVE RAYMLTSDFG 200
    YVAKVAKLEG NDGLGKVHIQ IGKPIRPMLA QNAASVKEAL LEMGAEAAFE 250
    IKYDGARVQV HKDGDRVVIY SRRLENVTRS IPEVVDAIKA SIKSEKAIVE 300
    GELVAVGEGG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDVLYVDGE 350
    PLIDTPFRER RAKLEEIVEE GEKLKLAQQL VTKKVEEAEE FYKKALELGH 400
    EGLMAKRLDS VYEPGNRGKK WLKIKPTMED LDLVIIGAEW GEGRRAHLLG 450
    SFLVAAYDPH SGEFVPVGKV GSGFTDEDLV EFTKMLKPLI IGGEGKFVEI 500
    EPKVVIQVTY QEIQKSPKYR SGFALRFPRY VALREDKSPE EADTIERIAQ 550
    LYEFQERFKA KK 562
    Length:562
    Mass (Da):63,655
    Last modified:January 24, 2006 - v1
    Checksum:iA54BDEB51585437D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ223722 Genomic DNA. Translation: ABC11973.1.
    RefSeqiYP_002307902.1. NC_011529.1.

    Genome annotation databases

    GeneIDi7018552.
    KEGGiton:TON_1515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ223722 Genomic DNA. Translation: ABC11973.1 .
    RefSeqi YP_002307902.1. NC_011529.1.

    3D structure databases

    ProteinModelPortali Q2Q452.
    SMRi Q2Q452. Positions 4-561.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7018552.
    KEGGi ton:TON_1515.

    Phylogenomic databases

    KOi K10747.

    Enzyme and pathway databases

    BRENDAi 6.5.1.1. 289156.
    6.5.1.2. 289156.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression and Characterization of a DNA ligase from the Hyperthermophilic Archaeon Thermococcus sp. NA1."
      Kim Y.J., Lee H.S., Kang S.G., Kwon S.-T., Lee J.-H.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NA1Imported.

    Entry informationi

    Entry nameiQ2Q452_9EURY
    AccessioniPrimary (citable) accession number: Q2Q452
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)