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Protein

Adhesion G protein-coupled receptor E2

Gene

ADGRE2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processCell adhesion, Inflammatory response
LigandCalcium

Protein family/group databases

MEROPSiP02.001

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E2
Alternative name(s):
EGF-like module receptor 2
EGF-like module-containing mucin-like hormone receptor-like 2
CD_antigen: CD312
Gene namesi
Name:ADGRE2
Synonyms:EMR2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 530ExtracellularCuratedAdd BLAST512
Transmembranei531 – 551Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini552 – 562CytoplasmicCuratedAdd BLAST11
Transmembranei563 – 583Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini584 – 589ExtracellularCurated6
Transmembranei590 – 610Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini611 – 637CytoplasmicCuratedAdd BLAST27
Transmembranei638 – 658Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini659 – 676ExtracellularCuratedAdd BLAST18
Transmembranei677 – 697Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini698 – 728CytoplasmicCuratedAdd BLAST31
Transmembranei729 – 749Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini750 – 753ExtracellularCurated4
Transmembranei754 – 774Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini775 – 822CytoplasmicCuratedAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025096119 – 822Adhesion G protein-coupled receptor E2Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 36PROSITE-ProRule annotation
Disulfide bondi30 ↔ 42PROSITE-ProRule annotation
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi68 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 91PROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Disulfide bondi127 ↔ 142PROSITE-ProRule annotation
Disulfide bondi144 ↔ 158PROSITE-ProRule annotation
Disulfide bondi164 ↔ 177PROSITE-ProRule annotation
Disulfide bondi171 ↔ 186PROSITE-ProRule annotation
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi213 ↔ 226PROSITE-ProRule annotation
Disulfide bondi220 ↔ 235PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei510 – 511Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ2Q426

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000024916

Structurei

3D structure databases

ProteinModelPortaliQ2Q426
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 63EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini64 – 103EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini116 – 159EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini160 – 198EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini209 – 247EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini472 – 522GPSPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 52Poly-Ser4
Compositional biasi537 – 619Leu-richAdd BLAST83

Domaini

The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.By similarity
Binding to chondroitin sulfate is mediated by the fourth EGF domain.By similarity

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
HOVERGENiHBG048917
InParanoidiQ2Q426
KOiK08443

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 4 hits
PF01825 GPS, 1 hit
PRINTSiPR01278 CD97PROTEIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00303 GPS, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 4 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2Q426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGRVFLAFC VWLTLLGAET QDSRDCARWC PENSSCVNAT ACRCNPGFSS
60 70 80 90 100
SSEIFTSPTE ICDDINECVP PSKVSCGKSS DCRNTEGSYD CVCNPGYELV
110 120 130 140 150
SGAKTFKNES ENTCQDVDEC QQNPRLCKSY GTCVNTLGSF TCQCLPGFKF
160 170 180 190 200
KPEDPKLCTD VNECTSGQNP CHSSTHCLNN VGSYQCRCRP GWQPIPGSPN
210 220 230 240 250
GPNNTICEDV DECSSGLHQC DNSTVCFNTV GSYTCRCRPG WEPKHGIPNN
260 270 280 290 300
QKDTVCKDMN FPTWTLPPGV HSQTLSQFFN KVQDLDRDFK TSSAKVTIQS
310 320 330 340 350
ILKELDELLE APGDLETLPR FQQHCVATHL LDGLEDVLRG LSKNPSIGLL
360 370 380 390 400
NFSYPAGTEF SLEVQKQVDR NVTLRQNQAT MQLHWNLAQK SGDPGPSVVG
410 420 430 440 450
LVSVPGMGKL LAEAPLVSEP ENQVVRNETH QGLLPILLSD VISAFLSNND
460 470 480 490 500
TQNLSSPVTF IFSHRSVIPR RKVLCVFWEH GQNGCGHWAT TGCSTMDTRD
510 520 530 540 550
TSTICRCTHL SSFAVLMAPY DVQEEDPVLT VITYMGLSLS LLCLLLAALT
560 570 580 590 600
FLLCKAIQNI STSLHLQLSL CLLLAHLLFL VAIDRTEHEV LCAIIASALH
610 620 630 640 650
YLYLAAFTWM LLEALYLFLT ARNLMVVNYS SINRFTKKLM FPVAYGVPAV
660 670 680 690 700
TVAISAASRP HLYGTPSRCW LQPEKGFIWG FLGPVCAIFS VNLALLLVTL
710 720 730 740 750
WILKNRLSSL NNEVSTLQNT RMLAFKATAQ LFILGCTWCL GILQVGPAAR
760 770 780 790 800
VMAYLFTIIN SLQGVFIFLV YCLLSQQVRE QYRKWSKGFR KLRTESEMHT
810 820
LSSSAKRDTP KPSTPGLLGL QS
Length:822
Mass (Da):90,787
Last modified:January 24, 2006 - v1
Checksum:i17129FD44C2170CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227271 mRNA Translation: ABB53642.1
RefSeqiNP_001033751.1, NM_001038662.1
UniGeneiMmu.9556

Genome annotation databases

GeneIDi654420
KEGGimcc:654420

Similar proteinsi

Entry informationi

Entry nameiAGRE2_MACMU
AccessioniPrimary (citable) accession number: Q2Q426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health