Q2Q3W1 (Q2Q3W1_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dicer-2 EMBL ABB54745.1

Gene names

Name:

Dcr-2 FlyBase FBgn0034246

Organism

Drosophila melanogaster (Fruit fly) EMBL ABB54745.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1715 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase RuleBase RU000452 Hydrolase
Gene Ontology (GO)
Biological process	defense response to virus Inferred from mutant phenotype. Source: FlyBase detection of virus Inferred from mutant phenotype. Source: FlyBase dsRNA transport Inferred from mutant phenotype. Source: FlyBase heterochromatin organization involved in chromatin silencing Inferred from mutant phenotype. Source: FlyBase locomotory behavior Inferred from mutant phenotype. Source: FlyBase production of siRNA involved in RNA interference Inferred from direct assay. Source: FlyBase siRNA loading onto RISC involved in RNA interference Inferred from mutant phenotype. Source: FlyBase targeting of mRNA for destruction involved in RNA interference Inferred from mutant phenotype. Source: FlyBase
Cellular component	RNA-induced silencing complex Inferred from direct assay. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: InterPro siRNA binding Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ABB54745.1

Sequences

	Sequence		Length	Mass (Da)
	Q2Q3W1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: A5F02FB757AD8582	FASTA	1,715	196,960
	10 20 30 40 50 60 PRGYQLRLVD HLTKSNGIVY LPTGSGKTFV AILVLKRFSQ DFDKPIESGG KRALFMCNTV 70 80 90 100 110 120 ELARQQAMAV RRCTNFKVGF YVGEQGVDDW TRGMWSDEIK KNQVLVGTAQ VFLDMVTQTY 130 140 150 160 170 180 VALSSLSVVI IDECHHGTGH HPFREFMRLF TIANQTKLPR VVGLTGVLIK GNEITNVATK 190 200 210 220 230 240 LKELEITYRG NIITVSDTKE MENVMLYATK PTEVMVSFPH QEQVLTVTRL ISAEIEKFYV 250 260 270 280 290 300 SLDLMNIGVQ PIRRSKSLQC LRDPSKKSFV KQLFNDFLYQ MKEYGIYAAS IAIISLIVEF 310 320 330 340 350 360 DIKRRQAETL SVKLMHRTAL TLCEKIRHLL VQKLQDMTYD DDDDNVNTEE VIMNFSTPKV 370 380 390 400 410 420 QRFLMSLKVS FADKDPKDIC CLVFVERRYT CKCIYGLLLN YIQSTPELRN VLTPQFMVGR 430 440 450 460 470 480 NNISPDFESV LERKWQKSAI QQFRDGNANL MICSSVLEEG IDVQACNHVF ILDPVKTFNM 490 500 510 520 530 540 YVQSKGRART TEAKFVLFTA DKEREKTIQQ IYQYRKAHND IAEYLKDRVL EKTEPELYEI 550 560 570 580 590 600 KGHFQDDIDP FTNENGAVLL PNNALAILHR YCQTIPTDAF GFVIPWFHVL QEDERDRIFG 610 620 630 640 650 660 VSAKGKHVIS INMPVNCMLR DTIYSDPMDN VKTAKISAAF KACKVLYSLG ELNERFVPKT 670 680 690 700 710 720 LKERVAAIAD VHFEHWNKYG DSVTATVNKA DKSKDRTYKT ECPLEFYDAL PRVGEICYAY 730 740 750 760 770 780 EIFLEPQFES CEYTEHMYLN LQTPRNYAIL LRNKLPRLAE MPLFSNQGKL HVRVANAPLE 790 800 810 820 830 840 VIIQNSEQLE LLHQFHGMVF RDILKIWHPF FVLDRRSKEN SYLVVPLILG AGEQKCFDWE 850 860 870 880 890 900 LMTNFRRLPQ SHGSNVQQRE QQPAPRPEDF EGKIVTQWYA NYDKRMLVTK VHRRLTPLSY 910 920 930 940 950 960 MEKNQQDKTY YEFTMSKYGN RIGDVVHKDK FMIEVRDLTE QLTFYVHNRG KFNAKSKAKM 970 980 990 1000 1010 1020 KVILIPELCF NFNFPGDLWL KLIFLPSILN RMYFLLHAEA LRKRFNTYLN LHLLPFNGTD 1030 1040 1050 1060 1070 1080 YMPRPLEIDY SLKRNVDPLG NVIPTEDIEE PKSLLEPMPT KSIEASVANL EITEFENPWQ 1090 1100 1110 1120 1130 1140 KYMEPVDLSR NLLSTYPVEL DYYYHFSVGN VCEMNEMDFE DKEYWAKNQF HMPTGNIYGN 1150 1160 1170 1180 1190 1200 RTPAKTNANV PALMPSRPTV RGKVKPLLIL QKTVSKEHIT PAEQGEFLAA ITASSAADVF 1210 1220 1230 1240 1250 1260 DMERLEILGD SFLKLSATLY LASKYSDWNE GTLTEVKSKL VSNRNLLFCL IDADIPKTLN 1270 1280 1290 1300 1310 1320 TIQFTPRYTW LPPGISLPHN VLALWRENPE FAKMIGPHNL RDLALGDEES LVKGNCSDIN 1330 1340 1350 1360 1370 1380 YNRFVEGCRA NGQSFYAGAD FSSEVNFCVG LVTIPNKVIA DTLEALLGVI VKNYGLQHAF 1390 1400 1410 1420 1430 1440 KMLEYFKICR ADIDKPLTQL LNLELGGKKM RANVNTTEID GFLINHSYLE KNLGYTFKDR 1450 1460 1470 1480 1490 1500 RYLLQALTHP SYPTNRITGS YQELEFIGDA ILDFLISAYI FENNTKMNPG ALTDLRSALV 1510 1520 1530 1540 1550 1560 NNTTLACICV RHRLHFFILA ENAKLSEIIS KFVNFQESQG HRVTNYVRIL LEEADVQPTP 1570 1580 1590 1600 1610 1620 LDLDDELDMT ELPHANKCIS QEAEKGVPPK GEFNMSTNVD VPKALGDVLE ALIAAVYLDC 1630 1640 1650 1660 1670 1680 RDLQRTWEVI FNLFEPELQE FTRKVPINHI RQLVEHKHAK PVFSSPIVEG ETVMVSCQFT 1690 1700 1710 CMEKTIKVYG FGSNKDQAKL SAAKHALQQL SKCDA

References

[1]	"Natural selection drives extremely rapid evolution in antiviral RNAi genes." Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J. Curr. Biol. 16:580-585(2006) [PubMed: 16546082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 128 EMBL ABB54745.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ228792 Genomic DNA. Translation: ABB54745.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2Q3W1.
Proteomic databases
PRIDE	Q2Q3W1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0034246. Dcr-2.
Phylogenomic databases
InParanoid	Q2Q3W1.
Gene expression databases
ArrayExpress	Q2Q3W1.
Bgee	Q2Q3W1.
Family and domain databases
InterPro	IPR014001. DEAD-like_helicase. IPR005034. Dicer_dsRNA_binding_fold. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR001159. Ds-RNA-bd. IPR001650. Helicase_C. IPR003100. PAZ. IPR000999. RNase_III. [Graphical view]
Gene3D	G3DSA:1.10.1520.10. RNase_III. 4 hits.
Pfam	PF00270. DEAD. 1 hit. PF00035. dsrm. 1 hit. PF03368. dsRNA_bind. 1 hit. PF00271. Helicase_C. 1 hit. PF02170. PAZ. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00358. DSRM. 1 hit. SM00490. HELICc. 1 hit. SM00949. PAZ. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view]
SUPFAM	SSF69065. RNase_III. 2 hits.
PROSITE	PS51327. DICER_DSRBF. 1 hit. PS50137. DS_RBD. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50821. PAZ. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2Q3W1_DROME

Accession

Primary (citable) accession number: Q2Q3W1

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)