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Protein

E3 ubiquitin-protein ligase TRIM71

Gene

TRIM71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 95RING-typePROSITE-ProRule annotationAdd BLAST84
Zinc fingeri194 – 241B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri273 – 314B box-type 2PROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

RNA-mediated gene silencing, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33790-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM71 (EC:6.3.2.-)
Alternative name(s):
Protein lin-41 homolog
Tripartite motif-containing protein 71
Gene namesi
Name:TRIM71
Synonyms:LIN41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:32669. TRIM71.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi131405.
OpenTargetsiENSG00000206557.
PharmGKBiPA144596246.

Polymorphism and mutation databases

BioMutaiTRIM71.
DMDMi121941685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002795112 – 868E3 ubiquitin-protein ligase TRIM71Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ2Q1W2.
MaxQBiQ2Q1W2.
PaxDbiQ2Q1W2.
PeptideAtlasiQ2Q1W2.
PRIDEiQ2Q1W2.

PTM databases

iPTMnetiQ2Q1W2.
PhosphoSitePlusiQ2Q1W2.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Inductioni

Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein. Down-regulated by retinoic acid in Tera-2 cells.1 Publication

Gene expression databases

BgeeiENSG00000206557.
CleanExiHS_TRIM71.
GenevisibleiQ2Q1W2. HS.

Organism-specific databases

HPAiHPA038141.
HPA038142.

Interactioni

Subunit structurei

Interacts (via NHL repeats) with AGO2. Interacts with SHCBP1; leading to enhance its stability (By similarity).By similarity

Protein-protein interaction databases

BioGridi126279. 17 interactors.
STRINGi9606.ENSP00000373272.

Structurei

3D structure databases

ProteinModelPortaliQ2Q1W2.
SMRiQ2Q1W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati479 – 580FilaminAdd BLAST102
Repeati593 – 636NHL 1Add BLAST44
Repeati640 – 683NHL 2Add BLAST44
Repeati687 – 730NHL 3Add BLAST44
Repeati734 – 777NHL 4Add BLAST44
Repeati781 – 824NHL 5Add BLAST44
Repeati828 – 868NHL 6Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili391 – 427Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 42Ser-richAdd BLAST17
Compositional biasi146 – 157His-richAdd BLAST12

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 6 NHL repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 95RING-typePROSITE-ProRule annotationAdd BLAST84
Zinc fingeri194 – 241B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri273 – 314B box-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG8. Eukaryota.
ENOG410XSQC. LUCA.
GeneTreeiENSGT00550000074377.
HOGENOMiHOG000006755.
HOVERGENiHBG081916.
InParanoidiQ2Q1W2.
KOiK12035.
OMAiMASFPET.
OrthoDBiEOG091G02WU.
PhylomeDBiQ2Q1W2.
TreeFamiTF331018.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF01436. NHL. 6 hits.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 2 hits.
SM00557. IG_FLMN. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
PS51125. NHL. 6 hits.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2Q1W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG
60 70 80 90 100
AAARRLHVLP CLHAFCRPCL EAHRLPAAGG GAAGEPLKLR CPVCDQKVVL
110 120 130 140 150
AEAAGMDALP SSAFLLSNLL DAVVATADEP PPKNGRAGAP AGAGGHSNHR
160 170 180 190 200
HHAHHAHPRA SASAPPLPQA PQPPAPSRSA PGGPAASPSA LLLRRPHGCS
210 220 230 240 250
SCDEGNAASS RCLDCQEHLC DNCVRAHQRV RLTKDHYIER GPPGPGAAAA
260 270 280 290 300
AQQLGLGPPF PGPPFSILSV FPERLGFCQH HDDEVLHLYC DTCSVPICRE
310 320 330 340 350
CTMGRHGGHS FIYLQEALQD SRALTIQLLA DAQQGRQAIQ LSIEQAQTVA
360 370 380 390 400
EQVEMKAKVV QSEVKAVTAR HKKALEEREC ELLWKVEKIR QVKAKSLYLQ
410 420 430 440 450
VEKLRQNLNK LESTISAVQQ VLEEGRALDI LLARDRMLAQ VQELKTVRSL
460 470 480 490 500
LQPQEDDRVM FTPPDQALYL AIKSFGFVSS GAFAPLTKAT GDGLKRALQG
510 520 530 540 550
KVASFTVIGY DHDGEPRLSG GDLMSAVVLG PDGNLFGAEV SDQQNGTYVV
560 570 580 590 600
SYRPQLEGEH LVSVTLCNQH IENSPFKVVV KSGRSYVGIG LPGLSFGSEG
610 620 630 640 650
DSDGKLCRPW GVSVDKEGYI IVADRSNNRI QVFKPCGAFH HKFGTLGSRP
660 670 680 690 700
GQFDRPAGVA CDASRRIVVA DKDNHRIQIF TFEGQFLLKF GEKGTKNGQF
710 720 730 740 750
NYPWDVAVNS EGKILVSDTR NHRIQLFGPD GVFLNKYGFE GALWKHFDSP
760 770 780 790 800
RGVAFNHEGH LVVTDFNNHR LLVIHPDCQS ARFLGSEGTG NGQFLRPQGV
810 820 830 840 850
AVDQEGRIIV ADSRNHRVQM FESNGSFLCK FGAQGSGFGQ MDRPSGIAIT
860
PDGMIVVVDF GNNRILVF
Length:868
Mass (Da):93,385
Last modified:January 24, 2006 - v1
Checksum:iA71A1E5CC019F80D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ232881 mRNA. Translation: ABB18374.1.
CCDSiCCDS43060.1.
RefSeqiNP_001034200.1. NM_001039111.2.
UniGeneiHs.113170.
Hs.567678.

Genome annotation databases

EnsembliENST00000383763; ENSP00000373272; ENSG00000206557.
GeneIDi131405.
KEGGihsa:131405.
UCSCiuc003cff.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ232881 mRNA. Translation: ABB18374.1.
CCDSiCCDS43060.1.
RefSeqiNP_001034200.1. NM_001039111.2.
UniGeneiHs.113170.
Hs.567678.

3D structure databases

ProteinModelPortaliQ2Q1W2.
SMRiQ2Q1W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126279. 17 interactors.
STRINGi9606.ENSP00000373272.

PTM databases

iPTMnetiQ2Q1W2.
PhosphoSitePlusiQ2Q1W2.

Polymorphism and mutation databases

BioMutaiTRIM71.
DMDMi121941685.

Proteomic databases

EPDiQ2Q1W2.
MaxQBiQ2Q1W2.
PaxDbiQ2Q1W2.
PeptideAtlasiQ2Q1W2.
PRIDEiQ2Q1W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383763; ENSP00000373272; ENSG00000206557.
GeneIDi131405.
KEGGihsa:131405.
UCSCiuc003cff.4. human.

Organism-specific databases

CTDi131405.
DisGeNETi131405.
GeneCardsiTRIM71.
HGNCiHGNC:32669. TRIM71.
HPAiHPA038141.
HPA038142.
neXtProtiNX_Q2Q1W2.
OpenTargetsiENSG00000206557.
PharmGKBiPA144596246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITG8. Eukaryota.
ENOG410XSQC. LUCA.
GeneTreeiENSGT00550000074377.
HOGENOMiHOG000006755.
HOVERGENiHBG081916.
InParanoidiQ2Q1W2.
KOiK12035.
OMAiMASFPET.
OrthoDBiEOG091G02WU.
PhylomeDBiQ2Q1W2.
TreeFamiTF331018.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:G66-33790-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii131405.
PROiQ2Q1W2.

Gene expression databases

BgeeiENSG00000206557.
CleanExiHS_TRIM71.
GenevisibleiQ2Q1W2. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF01436. NHL. 6 hits.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 2 hits.
SM00557. IG_FLMN. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
PS51125. NHL. 6 hits.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN41_HUMAN
AccessioniPrimary (citable) accession number: Q2Q1W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.