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Protein

Probable C-mannosyltransferase DPY19L1

Gene

DPY19L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L1 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 1
Protein dpy-19 homolog 1
Gene namesi
Name:DPY19L1
Synonyms:GA0500, KIAA0877
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22205. DPY19L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 88HelicalSequence analysisAdd BLAST23
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei186 – 208HelicalSequence analysisAdd BLAST23
Transmembranei236 – 254HelicalSequence analysisAdd BLAST19
Transmembranei260 – 279HelicalSequence analysisAdd BLAST20
Transmembranei286 – 303HelicalSequence analysisAdd BLAST18
Transmembranei309 – 325HelicalSequence analysisAdd BLAST17
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nuclear inner membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173852.
PharmGKBiPA142671946.

Polymorphism and mutation databases

BioMutaiDPY19L1.
DMDMi121941680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118771 – 675Probable C-mannosyltransferase DPY19L1Add BLAST675

Proteomic databases

EPDiQ2PZI1.
MaxQBiQ2PZI1.
PaxDbiQ2PZI1.
PeptideAtlasiQ2PZI1.
PRIDEiQ2PZI1.

PTM databases

iPTMnetiQ2PZI1.
PhosphoSitePlusiQ2PZI1.
SwissPalmiQ2PZI1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000173852.
CleanExiHS_DPY19L1.
ExpressionAtlasiQ2PZI1. baseline and differential.
GenevisibleiQ2PZI1. HS.

Organism-specific databases

HPAiHPA059139.

Interactioni

Protein-protein interaction databases

BioGridi116920. 15 interactors.
IntActiQ2PZI1. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ2PZI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4587. Eukaryota.
ENOG410XRWN. LUCA.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007991.
HOVERGENiHBG061402.
InParanoidiQ2PZI1.
OMAiLVTAYFF.
OrthoDBiEOG091G02PL.
PhylomeDBiQ2PZI1.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030041. DPY19L1.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF5. PTHR31488:SF5. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2PZI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGRPPPEGR PPPRPRTGRA PRGRRRAVFA AVLHWSHITH LFENDRHFSH
60 70 80 90 100
LSTLEREMAF RTEMGLYYSY FKTIVEAPSF LNGVWMIMND KLTEYPLVIN
110 120 130 140 150
TLKRFNLYPE VILASWYRIY TKIMDLIGIQ TKICWTVTRG EGLSPIESCE
160 170 180 190 200
GLGDPACFYV AVIFILNGLM MALFFIYGTY LSGSRLGGLV TVLCFFFNHG
210 220 230 240 250
ECTRVMWTPP LRESFSYPFL VLQMLLVTHI LRATKLYRGS LIALCISNVF
260 270 280 290 300
FMLPWQFAQF VLLTQIASLF AVYVVGYIDI CKLRKIIYIH MISLALCFVL
310 320 330 340 350
MFGNSMLLTS YYASSLVIIW GILAMKPHFL KINVSELSLW VIQGCFWLFG
360 370 380 390 400
TVILKYLTSK IFGIADDAHI GNLLTSKFFS YKDFDTLLYT CAAEFDFMEK
410 420 430 440 450
ETPLRYTKTL LLPVVLVVFV AIVRKIISDM WGVLAKQQTH VRKHQFDHGE
460 470 480 490 500
LVYHALQLLA YTALGILIMR LKLFLTPHMC VMASLICSRQ LFGWLFCKVH
510 520 530 540 550
PGAIVFAILA AMSIQGSANL QTQWNIVGEF SNLPQEELIE WIKYSTKPDA
560 570 580 590 600
VFAGAMPTMA SVKLSALRPI VNHPHYEDAG LRARTKIVYS MYSRKAAEEV
610 620 630 640 650
KRELIKLKVN YYILEESWCV RRSKPGCSMP EIWDVEDPAN AGKTPLCNLL
660 670
VKDSKPHFTT VFQNSVYKVL EVVKE
Length:675
Mass (Da):77,319
Last modified:January 24, 2006 - v1
Checksum:i89B82078AC235F3E
GO
Isoform 2 (identifier: Q2PZI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-590: Missing.

Show »
Length:85
Mass (Da):9,877
Checksum:i64046E7BE90747A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037332502G → V.Corresponds to variant rs1637696dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296281 – 590Missing in isoform 2. 1 PublicationAdd BLAST590

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ287932 mRNA. Translation: ABB89208.1.
BC029591 mRNA. Translation: AAH29591.1.
AB020684 mRNA. Translation: BAA74900.1.
CCDSiCCDS43567.1. [Q2PZI1-1]
RefSeqiNP_056098.1. NM_015283.1. [Q2PZI1-1]
UniGeneiHs.408623.

Genome annotation databases

EnsembliENST00000310974; ENSP00000308695; ENSG00000173852. [Q2PZI1-1]
ENST00000612226; ENSP00000478865; ENSG00000173852. [Q2PZI1-2]
GeneIDi23333.
KEGGihsa:23333.
UCSCiuc003tem.5. human. [Q2PZI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ287932 mRNA. Translation: ABB89208.1.
BC029591 mRNA. Translation: AAH29591.1.
AB020684 mRNA. Translation: BAA74900.1.
CCDSiCCDS43567.1. [Q2PZI1-1]
RefSeqiNP_056098.1. NM_015283.1. [Q2PZI1-1]
UniGeneiHs.408623.

3D structure databases

ProteinModelPortaliQ2PZI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116920. 15 interactors.
IntActiQ2PZI1. 3 interactors.

PTM databases

iPTMnetiQ2PZI1.
PhosphoSitePlusiQ2PZI1.
SwissPalmiQ2PZI1.

Polymorphism and mutation databases

BioMutaiDPY19L1.
DMDMi121941680.

Proteomic databases

EPDiQ2PZI1.
MaxQBiQ2PZI1.
PaxDbiQ2PZI1.
PeptideAtlasiQ2PZI1.
PRIDEiQ2PZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310974; ENSP00000308695; ENSG00000173852. [Q2PZI1-1]
ENST00000612226; ENSP00000478865; ENSG00000173852. [Q2PZI1-2]
GeneIDi23333.
KEGGihsa:23333.
UCSCiuc003tem.5. human. [Q2PZI1-1]

Organism-specific databases

CTDi23333.
GeneCardsiDPY19L1.
H-InvDBHIX0006593.
HIX0058364.
HGNCiHGNC:22205. DPY19L1.
HPAiHPA059139.
MIMi613892. gene.
neXtProtiNX_Q2PZI1.
OpenTargetsiENSG00000173852.
PharmGKBiPA142671946.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4587. Eukaryota.
ENOG410XRWN. LUCA.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007991.
HOVERGENiHBG061402.
InParanoidiQ2PZI1.
OMAiLVTAYFF.
OrthoDBiEOG091G02PL.
PhylomeDBiQ2PZI1.
TreeFamiTF313376.

Miscellaneous databases

GenomeRNAii23333.
PROiQ2PZI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173852.
CleanExiHS_DPY19L1.
ExpressionAtlasiQ2PZI1. baseline and differential.
GenevisibleiQ2PZI1. HS.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030041. DPY19L1.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF5. PTHR31488:SF5. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD19L1_HUMAN
AccessioniPrimary (citable) accession number: Q2PZI1
Secondary accession number(s): O94954, Q4G151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It has been suggested that DPY19L1 has a related pseudogene DPY19L1P1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.