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Q2PYT3

- Q2PYT3_RAT

UniProt

Q2PYT3 - Q2PYT3_RAT

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Protein
Submitted name:

ABL1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ABL1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

PTM / Processingi

Proteomic databases

PaxDbiQ2PYT3.

Expressioni

Gene expression databases

GenevestigatoriQ2PYT3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044534.

Structurei

3D structure databases

ProteinModelPortaliQ2PYT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation
Contains SH3 domain.SAAS annotation
Contains SHdomain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2PYT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR
60 70 80 90 100
PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS
110 120 130 140 150
ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP
160 170 180 190 200
VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD
210 220 230 240 250
GKLYVSSESR FNTLAELVHH HSIVADGLIT TLHYPAPKRN KPTIYGVSPN
260 270 280 290 300
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE
310 320 330 340 350
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN
360 370 380 390 400
RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD
410 420 430 440 450
FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE
460 470 480 490 500
IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS
510 520 530 540 550
DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGMRGAAGS TLQAPELPTK
560 570 580 590 600
TRTCRKTAEQ KDAPDALELL HTKGLGESDA ALDSEPAVSP LLPRKERGPP
610 620 630 640 650
DGSLNEDERL LPKDKKTNLF SALIKKKKKM APTPPKRSSS FREMDGQSER
660 670 680 690 700
RGASEDDGRE ISNGPPALTS DAVEPTKSPK ASNGAGVPNG AFREPGNSGF
710 720 730 740 750
RSPHVWKKCS TLTSSRLAAA EEESGLSSSK RFLRSCSASC MPHGVRDTEW
760 770 780 790 800
RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAT
810 820 830 840 850
PPPRLVKKTE EAAEDVFKDT ESSPGSSPPS LTPKLLRRQV PASPSSGPSH
860 870 880 890 900
KDEATKGNAS GMGTPATAEP AAPSNKAGLS KASSEEPRAR RHKHSSESPG
910 920 930 940 950
RDKGRLSKLK PAPPPPPSST GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS
960 970 980 990 1000
VDAVNSDPTK AGQPGEGLRK SVPPSVPKPQ SATKPPGTPT SPVSTPSTAP
1010 1020 1030 1040 1050
APSPLAGDQQ PSSAAFIPLI STRVSLRKTR QPPERIASGT ITKGVVLDST
1060 1070 1080 1090 1100
EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA
1110 1120 1130 1140
INKLESNLRE LQICPATASS GPAATQDFSK LLSSVKEISD IVRR
Length:1,144
Mass (Da):124,736
Last modified:January 24, 2006 - v1
Checksum:i212B1DEA4BBEB83B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1144 – 11441Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294402 mRNA. Translation: ABC46643.1.
UniGeneiRn.3105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294402 mRNA. Translation: ABC46643.1 .
UniGenei Rn.3105.

3D structure databases

ProteinModelPortali Q2PYT3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000044534.

Proteomic databases

PaxDbi Q2PYT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000231988.
HOVERGENi HBG004162.

Gene expression databases

Genevestigatori Q2PYT3.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rattus norvegicus Abl Abelson murine leukemia variant 1 mRNA."
    Li Q.F., Tang D.D.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle."
    Jia L., Tang D.D.
    Am. J. Physiol. Cell Physiol. 299:C630-C637(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ2PYT3_RAT
AccessioniPrimary (citable) accession number: Q2PYT3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)