Q2PYT3 (Q2PYT3_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
ABL1 EMBL ABC46643.1

Gene names

Name:

Abl1 RGD 1584969

Organism

Rattus norvegicus (Rat) EMBL ABC46643.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1144 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266
Sequence similarities	Contains 1 SH2 domain. SAAS SAAS008266 Contains 1 SH3 domain. RuleBase RU003338 SAAS SAAS008266 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338 SAAS SAAS008266
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS008266
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1144	1	EMBL ABC46643.1

Sequences

	Sequence		Length	Mass (Da)
	Q2PYT3 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 212B1DEA4BBEB83B	FASTA	1,144	124,736
	10 20 30 40 50 60 MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR PVASDFEPQG 70 80 90 100 110 120 LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 130 140 150 160 170 180 AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR 190 200 210 220 230 240 SISLRYEGRV YHYRINTASD GKLYVSSESR FNTLAELVHH HSIVADGLIT TLHYPAPKRN 250 260 270 280 290 300 KPTIYGVSPN YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 310 320 330 340 350 360 EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVSAVVLL 370 380 390 400 410 420 YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF 430 440 450 460 470 480 PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP 490 500 510 520 530 540 EGCPEKVYEL MRACWQWNPS DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGMRGAAGS 550 560 570 580 590 600 TLQAPELPTK TRTCRKTAEQ KDAPDALELL HTKGLGESDA ALDSEPAVSP LLPRKERGPP 610 620 630 640 650 660 DGSLNEDERL LPKDKKTNLF SALIKKKKKM APTPPKRSSS FREMDGQSER RGASEDDGRE 670 680 690 700 710 720 ISNGPPALTS DAVEPTKSPK ASNGAGVPNG AFREPGNSGF RSPHVWKKCS TLTSSRLAAA 730 740 750 760 770 780 EEESGLSSSK RFLRSCSASC MPHGVRDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA 790 800 810 820 830 840 LPRKRTSESR SEQVAKSTAT PPPRLVKKTE EAAEDVFKDT ESSPGSSPPS LTPKLLRRQV 850 860 870 880 890 900 PASPSSGPSH KDEATKGNAS GMGTPATAEP AAPSNKAGLS KASSEEPRAR RHKHSSESPG 910 920 930 940 950 960 RDKGRLSKLK PAPPPPPSST GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS VDAVNSDPTK 970 980 990 1000 1010 1020 AGQPGEGLRK SVPPSVPKPQ SATKPPGTPT SPVSTPSTAP APSPLAGDQQ PSSAAFIPLI 1030 1040 1050 1060 1070 1080 STRVSLRKTR QPPERIASGT ITKGVVLDST EALCLAISRN SEQMASHSAV LEAGKNLYTF 1090 1100 1110 1120 1130 1140 CVSYVDSIQQ MRNKFAFREA INKLESNLRE LQICPATASS GPAATQDFSK LLSSVKEISD IVRR

References

[1]	"Rattus norvegicus Abl Abelson murine leukemia variant 1 mRNA." Li Q.F., Tang D.D. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL ABC46643.1.
[2]	"Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle." Jia L., Tang D.D. Am. J. Physiol. Cell Physiol. 299:C630-C637(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL ABC46643.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ294402 mRNA. Translation: ABC46643.1.
IPI	IPI00370643.
UniGene	Rn.3105.
3D structure databases
ProteinModelPortal	Q2PYT3.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000044534. Q2PYT3.
Proteomic databases
PaxDb	Q2PYT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000231988.
HOVERGEN	HBG004162.
InParanoid	Q2PYT3.
OrthoDB	EOG40P460.
Gene expression databases
Genevestigator	Q2PYT3.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR015015. F-actin_binding. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF08919. F_actin_bind. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00808. FABD. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2PYT3_RAT

Accession

Primary (citable) accession number: Q2PYT3

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)