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Q2PYT3

- Q2PYT3_RAT

UniProt

Q2PYT3 - Q2PYT3_RAT

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Protein
Submitted name:

ABL1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ABL1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

PTM / Processingi

Proteomic databases

PaxDbiQ2PYT3.

Expressioni

Gene expression databases

GenevestigatoriQ2PYT3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044534.

Structurei

3D structure databases

ProteinModelPortaliQ2PYT3.

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation
Contains SH3 domain.SAAS annotations
Contains SHdomain.SAAS annotations

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.
InParanoidiQ2PYT3.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2PYT3-1 [UniParc]FASTAAdd to Basket

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MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR     50
PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS 100
ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP 150
VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD 200
GKLYVSSESR FNTLAELVHH HSIVADGLIT TLHYPAPKRN KPTIYGVSPN 250
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 300
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN 350
RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD 400
FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE 450
IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 500
DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGMRGAAGS TLQAPELPTK 550
TRTCRKTAEQ KDAPDALELL HTKGLGESDA ALDSEPAVSP LLPRKERGPP 600
DGSLNEDERL LPKDKKTNLF SALIKKKKKM APTPPKRSSS FREMDGQSER 650
RGASEDDGRE ISNGPPALTS DAVEPTKSPK ASNGAGVPNG AFREPGNSGF 700
RSPHVWKKCS TLTSSRLAAA EEESGLSSSK RFLRSCSASC MPHGVRDTEW 750
RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAT 800
PPPRLVKKTE EAAEDVFKDT ESSPGSSPPS LTPKLLRRQV PASPSSGPSH 850
KDEATKGNAS GMGTPATAEP AAPSNKAGLS KASSEEPRAR RHKHSSESPG 900
RDKGRLSKLK PAPPPPPSST GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS 950
VDAVNSDPTK AGQPGEGLRK SVPPSVPKPQ SATKPPGTPT SPVSTPSTAP 1000
APSPLAGDQQ PSSAAFIPLI STRVSLRKTR QPPERIASGT ITKGVVLDST 1050
EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA 1100
INKLESNLRE LQICPATASS GPAATQDFSK LLSSVKEISD IVRR 1144
Length:1,144
Mass (Da):124,736
Last modified:January 24, 2006 - v1
Checksum:i212B1DEA4BBEB83B
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1144 – 11441Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294402 mRNA. Translation: ABC46643.1.
UniGeneiRn.3105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294402 mRNA. Translation: ABC46643.1 .
UniGenei Rn.3105.

3D structure databases

ProteinModelPortali Q2PYT3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000044534.

Proteomic databases

PaxDbi Q2PYT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000231988.
HOVERGENi HBG004162.
InParanoidi Q2PYT3.

Gene expression databases

Genevestigatori Q2PYT3.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rattus norvegicus Abl Abelson murine leukemia variant 1 mRNA."
    Li Q.F., Tang D.D.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle."
    Jia L., Tang D.D.
    Am. J. Physiol. Cell Physiol. 299:C630-C637(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ2PYT3_RAT
AccessioniPrimary (citable) accession number: Q2PYT3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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