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Q2PYT3

- Q2PYT3_RAT

UniProt

Q2PYT3 - Q2PYT3_RAT

Protein
Submitted name:

ABL1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ABL1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    PTM / Processingi

    Proteomic databases

    PaxDbiQ2PYT3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ2PYT3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000044534.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2PYT3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SH3 domain.UniRule annotation
    Contains SH3 domain.SAAS annotation
    Contains SHdomain.SAAS annotation

    Keywords - Domaini

    SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231988.
    HOVERGENiHBG004162.
    InParanoidiQ2PYT3.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q2PYT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR     50
    PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS 100
    ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP 150
    VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD 200
    GKLYVSSESR FNTLAELVHH HSIVADGLIT TLHYPAPKRN KPTIYGVSPN 250
    YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 300
    EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN 350
    RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD 400
    FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE 450
    IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 500
    DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGMRGAAGS TLQAPELPTK 550
    TRTCRKTAEQ KDAPDALELL HTKGLGESDA ALDSEPAVSP LLPRKERGPP 600
    DGSLNEDERL LPKDKKTNLF SALIKKKKKM APTPPKRSSS FREMDGQSER 650
    RGASEDDGRE ISNGPPALTS DAVEPTKSPK ASNGAGVPNG AFREPGNSGF 700
    RSPHVWKKCS TLTSSRLAAA EEESGLSSSK RFLRSCSASC MPHGVRDTEW 750
    RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAT 800
    PPPRLVKKTE EAAEDVFKDT ESSPGSSPPS LTPKLLRRQV PASPSSGPSH 850
    KDEATKGNAS GMGTPATAEP AAPSNKAGLS KASSEEPRAR RHKHSSESPG 900
    RDKGRLSKLK PAPPPPPSST GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS 950
    VDAVNSDPTK AGQPGEGLRK SVPPSVPKPQ SATKPPGTPT SPVSTPSTAP 1000
    APSPLAGDQQ PSSAAFIPLI STRVSLRKTR QPPERIASGT ITKGVVLDST 1050
    EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA 1100
    INKLESNLRE LQICPATASS GPAATQDFSK LLSSVKEISD IVRR 1144
    Length:1,144
    Mass (Da):124,736
    Last modified:January 24, 2006 - v1
    Checksum:i212B1DEA4BBEB83B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1144 – 11441Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ294402 mRNA. Translation: ABC46643.1.
    UniGeneiRn.3105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ294402 mRNA. Translation: ABC46643.1 .
    UniGenei Rn.3105.

    3D structure databases

    ProteinModelPortali Q2PYT3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000044534.

    Proteomic databases

    PaxDbi Q2PYT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231988.
    HOVERGENi HBG004162.
    InParanoidi Q2PYT3.

    Gene expression databases

    Genevestigatori Q2PYT3.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rattus norvegicus Abl Abelson murine leukemia variant 1 mRNA."
      Li Q.F., Tang D.D.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    2. "Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle."
      Jia L., Tang D.D.
      Am. J. Physiol. Cell Physiol. 299:C630-C637(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiQ2PYT3_RAT
    AccessioniPrimary (citable) accession number: Q2PYT3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)