ID   AICDA_BOVIN             Reviewed;         199 AA.
AC   Q2PT36;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Activation-induced cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
GN   Name=AICDA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RA   Verma S., Aitken R.;
RT   "Functional characterization of activation induced cytidine deaminase
RT   of Bos taurus.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-editing deaminase involved in somatic hypermutation,
CC       gene conversion, and class-switch recombination. Required for
CC       several crucial steps of B-cell terminal differentiation necessary
CC       for efficient antibody responses (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; DQ303466; ABC46408.1; -; mRNA.
DR   IPI; IPI00696737; -.
DR   RefSeq; NP_001033771.1; -.
DR   UniGene; Bt.56893; -.
DR   Ensembl; ENSBTAG00000018849; Bos taurus.
DR   GeneID; 539888; -.
DR   KEGG; bta:539888; -.
DR   HOVERGEN; Q2PT36; -.
DR   BRENDA; 3.5.4.5; 251.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR007904; APOBEC_C.
DR   InterPro; IPR013158; APOBEC_N.
DR   Pfam; PF05240; APOBEC_C; 1.
DR   Pfam; PF08210; APOBEC_N; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; mRNA processing; Zinc.
FT   CHAIN         1    199       Activation-induced cytidine deaminase.
FT                                /FTId=PRO_0000232719.
FT   ACT_SITE     58     58       Proton donor (By similarity).
FT   METAL        56     56       Zinc; catalytic (By similarity).
FT   METAL        87     87       Zinc; catalytic (By similarity).
FT   METAL        90     90       Zinc; catalytic (By similarity).
SQ   SEQUENCE   199 AA;  24052 MW;  448413C29E2A98D2 CRC64;
     MDSLLKKQRQ FLYQFKNVRW AKGRHETYLC YVVKRRDSPT SFSLDFGHLR NKAGCHVELL
     FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG YPNLSLRIFT ARLYFCDKER
     KAEPEGLRRL HRAGVQIAIM TFKDYFYCWN TFVENHERTF KAWEGLHENS VRLSRQLRRI
     LLPLYEVDDL RDAFRTLGL
//