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Q2PT36

- AICDA_BOVIN

UniProt

Q2PT36 - AICDA_BOVIN

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Protein

Single-stranded DNA cytosine deaminase

Gene
AICDA
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation By similarity.

Catalytic activityi

Cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Zinc; catalytic By similarity
Active sitei58 – 581Proton donor By similarity
Metal bindingi87 – 871Zinc; catalytic By similarity
Metal bindingi90 – 901Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cytidine deamination Source: UniProtKB
  2. DNA demethylation Source: UniProtKB
  3. mRNA processing Source: UniProtKB-KW
  4. negative regulation of methylation-dependent chromatin silencing Source: UniProtKB
  5. somatic hypermutation of immunoglobulin genes Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA cytosine deaminase (EC:3.5.4.38)
Alternative name(s):
Activation-induced cytidine deaminase
Cytidine aminohydrolase
Gene namesi
Name:AICDA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Single-stranded DNA cytosine deaminasePRO_0000232719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphothreonine; by PKA By similarity
Modified residuei38 – 381Phosphoserine; by PKA By similarity

Post-translational modificationi

Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2PT36.

Expressioni

Tissue specificityi

Expressed in lymph nodes, spleen and thymus.1 Publication

Interactioni

Subunit structurei

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1 By similarity. Interacts with SUPT6H, TRIM28 and NCL By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025096.

Structurei

3D structure databases

ProteinModelPortaliQ2PT36.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030Nuclear localization signal By similarityAdd
BLAST
Regioni2 – 2625Interaction with SUPT6H By similarityAdd
BLAST
Regioni39 – 424Important for interaction with CTNNBL1 By similarity
Regioni184 – 19916Nuclear export signal By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG39659.
HOGENOMiHOG000033754.
HOVERGENiHBG050434.
InParanoidiQ2PT36.
KOiK10989.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2PT36-1 [UniParc]FASTAAdd to Basket

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MDSLLKKQRQ FLYQFKNVRW AKGRHETYLC YVVKRRDSPT SFSLDFGHLR    50
NKAGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG 100
YPNLSLRIFT ARLYFCDKER KAEPEGLRRL HRAGVQIAIM TFKDYFYCWN 150
TFVENHERTF KAWEGLHENS VRLSRQLRRI LLPLYEVDDL RDAFRTLGL 199
Length:199
Mass (Da):24,052
Last modified:January 24, 2006 - v1
Checksum:i448413C29E2A98D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ303466 mRNA. Translation: ABC46408.1.
RefSeqiNP_001033771.1. NM_001038682.1.
UniGeneiBt.56893.

Genome annotation databases

GeneIDi539888.
KEGGibta:539888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ303466 mRNA. Translation: ABC46408.1 .
RefSeqi NP_001033771.1. NM_001038682.1.
UniGenei Bt.56893.

3D structure databases

ProteinModelPortali Q2PT36.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000025096.

Proteomic databases

PRIDEi Q2PT36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 539888.
KEGGi bta:539888.

Organism-specific databases

CTDi 57379.

Phylogenomic databases

eggNOGi NOG39659.
HOGENOMi HOG000033754.
HOVERGENi HBG050434.
InParanoidi Q2PT36.
KOi K10989.

Miscellaneous databases

NextBioi 20878282.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF08210. APOBEC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of activation induced cytidine deaminase from Bos taurus."
    Verma S., Goldammer T., Aitken R.
    Vet. Immunol. Immunopathol. 134:151-159(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Spleen.

Entry informationi

Entry nameiAICDA_BOVIN
AccessioniPrimary (citable) accession number: Q2PT36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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