Reviewed, UniProtKB/Swiss-Prot Q2PT36 (AICDA_BOVIN)

Names and origin

Protein names

Recommended name:
    Activation-induced cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase

Gene names

Name:

AICDA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Biological process	mRNA processing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Activation-induced cytidine deaminase		PRO_0000232719
Sites
	Active site	58	1	Proton donor By similarity
	Metal binding	56	1	Zinc; catalytic By similarity
	Metal binding	87	1	Zinc; catalytic By similarity
	Metal binding	90	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2PT36-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 448413C29E2A98D2	FASTA	199	24,052
	10 20 30 40 50 60 MDSLLKKQRQ FLYQFKNVRW AKGRHETYLC YVVKRRDSPT SFSLDFGHLR NKAGCHVELL 70 80 90 100 110 120 FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG YPNLSLRIFT ARLYFCDKER 130 140 150 160 170 180 KAEPEGLRRL HRAGVQIAIM TFKDYFYCWN TFVENHERTF KAWEGLHENS VRLSRQLRRI 190 LLPLYEVDDL RDAFRTLGL

References

[1]	"Functional characterization of activation induced cytidine deaminase of Bos taurus." Verma S., Aitken R. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ303466 mRNA. Translation: ABC46408.1.
IPI	IPI00696737.
RefSeq	NP_001033771.1.
UniGene	Bt.56893
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000018849. Bos taurus. [Contig view]
GeneID	539888.
KEGG	bta:539888.
Phylogenomic databases
HOVERGEN	Q2PT36.
Enzyme and pathway databases
BRENDA	3.5.4.5. 251.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR007904. APOBEC_C. IPR013158. APOBEC_N. [Graphical view]
Pfam	PF05240. APOBEC_C. 1 hit. PF08210. APOBEC_N. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AICDA_BOVIN

Accession

Primary (citable) accession number: Q2PT36

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)