Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2PS21

- MT3_RABIT

UniProt

Q2PS21 - MT3_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Metallothionein-3

Gene

MT3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi62 – 621Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
Metal bindingi65 – 651Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. cadmium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  4. drug binding Source: UniProtKB
  5. protein kinase activator activity Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase B activity Source: UniProtKB
  2. astrocyte development Source: UniProtKB
  3. cadmium ion homeostasis Source: UniProtKB
  4. cellular lipid catabolic process Source: UniProtKB
  5. cellular response to cadmium ion Source: UniProtKB
  6. cellular response to drug Source: UniProtKB
  7. cellular response to nitric oxide Source: UniProtKB
  8. cellular response to oxidative stress Source: UniProtKB
  9. cellular zinc ion homeostasis Source: UniProtKB
  10. cholesterol catabolic process Source: UniProtKB
  11. energy reserve metabolic process Source: UniProtKB
  12. ERK1 and ERK2 cascade Source: UniProtKB
  13. histone modification Source: UniProtKB
  14. leptin-mediated signaling pathway Source: UniProtKB
  15. negative regulation of apoptotic process Source: UniProtKB
  16. negative regulation of autophagy Source: UniProtKB
  17. negative regulation of axon extension Source: UniProtKB
  18. negative regulation of cell growth Source: UniProtKB
  19. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
  20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  21. negative regulation of necrotic cell death Source: UniProtKB
  22. negative regulation of neuron apoptotic process Source: UniProtKB
  23. negative regulation of oxidoreductase activity Source: UniProtKB
  24. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  25. negative regulation of transcription, DNA-templated Source: UniProtKB
  26. positive regulation of catalytic activity Source: UniProtKB
  27. positive regulation of cell death Source: UniProtKB
  28. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  29. positive regulation of gene expression Source: UniProtKB
  30. positive regulation of lysosomal membrane permeability Source: UniProtKB
  31. positive regulation of necrotic cell death Source: UniProtKB
  32. positive regulation of oxygen metabolic process Source: UniProtKB
  33. positive regulation of protein phosphorylation Source: UniProtKB
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
  36. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  37. protein import into nucleus, translocation Source: UniProtKB
  38. protein kinase B signaling Source: UniProtKB
  39. protein stabilization Source: UniProtKB
  40. regulation of protein glycosylation Source: UniProtKB
  41. regulation of response to food Source: UniProtKB
  42. removal of superoxide radicals Source: UniProtKB
  43. response to hypoxia Source: UniProtKB
  44. zinc ion homeostasis Source: UniProtKB
  45. zinc ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. inclusion body Source: UniProtKB
  2. intracellular Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. synaptic vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Metallothionein-3PRO_0000253582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliQ2PS21.
SMRiQ2PS21. Positions 32-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6636AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG132957.
HOGENOMiHOG000236262.
InParanoidiQ2PS21.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2PS21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCEDSC KCQGCKCTSC KKSCCSCCPA ECEKCAKDCV
60
CKGGEGAEAE KCSCCQ
Length:66
Mass (Da):6,784
Last modified:January 24, 2006 - v1
Checksum:iE1B4473AC62DD7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ304562 mRNA. Translation: ABC18332.1.
DQ304563 mRNA. Translation: ABC18333.1.
UniGeneiOcu.1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ304562 mRNA. Translation: ABC18332.1 .
DQ304563 mRNA. Translation: ABC18333.1 .
UniGenei Ocu.1799.

3D structure databases

ProteinModelPortali Q2PS21.
SMRi Q2PS21. Positions 32-66.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG132957.
HOGENOMi HOG000236262.
InParanoidi Q2PS21.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The cloning of rabbit neuronal growth inhibitory factor coding sequence."
    Bai Z., Ren H.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMT3_RABIT
AccessioniPrimary (citable) accession number: Q2PS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3