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Protein

Metallothionein-3

Gene

MT3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi62 – 621Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
Metal bindingi65 – 651Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Metallothionein-3PRO_0000253582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013959.

Structurei

3D structure databases

ProteinModelPortaliQ2PS21.
SMRiQ2PS21. Positions 32-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6636AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KFJ7. Eukaryota.
ENOG4110T98. LUCA.
HOGENOMiHOG000236262.
InParanoidiQ2PS21.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2PS21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCEDSC KCQGCKCTSC KKSCCSCCPA ECEKCAKDCV
60
CKGGEGAEAE KCSCCQ
Length:66
Mass (Da):6,784
Last modified:January 24, 2006 - v1
Checksum:iE1B4473AC62DD7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ304562 mRNA. Translation: ABC18332.1.
DQ304563 mRNA. Translation: ABC18333.1.
UniGeneiOcu.1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ304562 mRNA. Translation: ABC18332.1.
DQ304563 mRNA. Translation: ABC18333.1.
UniGeneiOcu.1799.

3D structure databases

ProteinModelPortaliQ2PS21.
SMRiQ2PS21. Positions 32-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410KFJ7. Eukaryota.
ENOG4110T98. LUCA.
HOGENOMiHOG000236262.
InParanoidiQ2PS21.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_RABIT
AccessioniPrimary (citable) accession number: Q2PS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 24, 2006
Last modified: July 6, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.