Reviewed, UniProtKB/Swiss-Prot Q2PS21 (MT3_RABIT)

Names and origin

Protein names

Recommended name:
    Metallothionein-3
      Short name=MT-3
Alternative name(s):
    Metallothionein-III
      Short name=MT-III
    Growth inhibitory factor
      Short name=GIF

Gene names

Name:

MT3

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	66 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium By similarity.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Gene Ontology (GO)
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 66	66	Metallothionein-3		PRO_0000253582
Regions
	Region	1 – 30	30	Beta
	Region	31 – 66	36	Alpha
Sites
	Metal binding	6	1	Cluster B By similarity
	Metal binding	8	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	16	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	22	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	27	1	Cluster B By similarity
	Metal binding	30	1	Cluster B By similarity
	Metal binding	34	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	37	1	Cluster A By similarity
	Metal binding	38	1	Cluster A By similarity
	Metal binding	42	1	Cluster A By similarity
	Metal binding	45	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	51	1	Cluster A By similarity
	Metal binding	62	1	Cluster A By similarity
	Metal binding	64	1	Cluster A By similarity
	Metal binding	65	1	Cluster A By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2PS21-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: E1B4473AC62DD7E9	FASTA	66	6,784
	10 20 30 40 50 60 MDPETCPCPT GGSCTCEDSC KCQGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE KCSCCQ

References

[1]	"The cloning of rabbit neuronal growth inhibitory factor coding sequence." Bai Z., Ren H. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ304562 mRNA. Translation: ABC18332.1. DQ304563 mRNA. Translation: ABC18333.1.
RefSeq	NP_001075689.1.
UniGene	Ocu.1799
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2PS21.
Genome annotation databases
Ensembl	ENSOCUT00000016238; ENSOCUP00000013959; ENSOCUG00000016243; Oryctolagus cuniculus. [Genome view]
GeneID	100009025.
Phylogenomic databases
HOVERGEN	Q2PS21.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT3_RABIT

Accession

Primary (citable) accession number: Q2PS21

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	January 24, 2006
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)