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Q2PQN9

- CDK5_GLOMM

UniProt

Q2PQN9 - CDK5_GLOMM

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Protein

Cyclin-dependent kinase 5 homolog

Gene
Cdk5
Organism
Glossina morsitans morsitans (Savannah tsetse fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei126 – 1261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 5
Gene namesi
Name:Cdk5
OrganismiGlossina morsitans morsitans (Savannah tsetse fly)
Taxonomic identifieri37546 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent kinase 5 homologPRO_0000291621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei159 – 1591Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2PQN9.

Structurei

3D structure databases

ProteinModelPortaliQ2PQN9.
SMRiQ2PQN9. Positions 1-288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinaseAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2PQN9-1 [UniParc]FASTAAdd to Basket

« Hide

MQKYEKLEKI GEGTYGTVFK GRNRETLEIV ALKRVRLDED DEGVPSSALR    50
EICLLKELKH KNIVRLYDVL HSEKKLTLVF EHCDQDLKKY FDSLNGDIDM 100
AVCRSFMLQL LRGLAFCHSH NVLHRDLKPQ NLLINKNGEL KLADFGLARA 150
FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT TSIDMWSAGC IFAELADAGR 200
PLFPGSDVLD QLMKIFRVLG TPTEESWPGV THLSDYVALP HFPAITSWSQ 250
IVPRLSSKGR DLLQKLLVCR PNQRVSAEQA MQHPYFTDSS NH 292
Length:292
Mass (Da):33,206
Last modified:January 24, 2006 - v1
Checksum:i8BE6A37641CF9ED8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ307184 mRNA. Translation: ABC25084.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ307184 mRNA. Translation: ABC25084.1 .

3D structure databases

ProteinModelPortali Q2PQN9.
SMRi Q2PQN9. Positions 1-288.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q2PQN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans."
    Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.
    Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fat body.

Entry informationi

Entry nameiCDK5_GLOMM
AccessioniPrimary (citable) accession number: Q2PQN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: October 16, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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