Q2PQN9 (CDK5_GLOMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 5 homolog
EC=2.7.11.22

Alternative name(s):
Cell division protein kinase 5

Gene names

Name:

Cdk5

Organism

Glossina morsitans morsitans (Savannah tsetse fly)

Taxonomic identifier

37546 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Calyptratae › Hippoboscoidea › Glossinidae › Glossina › Glossina › Glossina morsitans

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Cyclin-dependent kinase 5 homolog		PRO_0000291621
Regions
	Domain	4 – 286	283	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	126	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Amino acid modifications
	Modified residue	14	1	Phosphothreonine By similarity
	Modified residue	15	1	Phosphotyrosine By similarity
	Modified residue	159	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2PQN9 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8BE6A37641CF9ED8	FASTA	292	33,206
	10 20 30 40 50 60 MQKYEKLEKI GEGTYGTVFK GRNRETLEIV ALKRVRLDED DEGVPSSALR EICLLKELKH 70 80 90 100 110 120 KNIVRLYDVL HSEKKLTLVF EHCDQDLKKY FDSLNGDIDM AVCRSFMLQL LRGLAFCHSH 130 140 150 160 170 180 NVLHRDLKPQ NLLINKNGEL KLADFGLARA FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT 190 200 210 220 230 240 TSIDMWSAGC IFAELADAGR PLFPGSDVLD QLMKIFRVLG TPTEESWPGV THLSDYVALP 250 260 270 280 290 HFPAITSWSQ IVPRLSSKGR DLLQKLLVCR PNQRVSAEQA MQHPYFTDSS NH

References

[1]

"Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans." Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S. Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fat body.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ307184 mRNA. Translation: ABC25084.1.
3D structure databases
HSSP	HSSP built from PDB template 2BTR based on UniProtKB P24941.
ProteinModelPortal	Q2PQN9.
SMR	Q2PQN9. Positions 1-288.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK5_GLOMM

Accession

Primary (citable) accession number: Q2PQN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)