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Q2PQN9 (CDK5_GLOMM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 5 homolog

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 5
Gene names
Name:Cdk5
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
Taxonomic identifier37546 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Cyclin-dependent kinase 5 homolog
PRO_0000291621

Regions

Domain4 – 286283Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1591Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2PQN9 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 8BE6A37641CF9ED8

FASTA29233,206
        10         20         30         40         50         60 
MQKYEKLEKI GEGTYGTVFK GRNRETLEIV ALKRVRLDED DEGVPSSALR EICLLKELKH 

        70         80         90        100        110        120 
KNIVRLYDVL HSEKKLTLVF EHCDQDLKKY FDSLNGDIDM AVCRSFMLQL LRGLAFCHSH 

       130        140        150        160        170        180 
NVLHRDLKPQ NLLINKNGEL KLADFGLARA FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT 

       190        200        210        220        230        240 
TSIDMWSAGC IFAELADAGR PLFPGSDVLD QLMKIFRVLG TPTEESWPGV THLSDYVALP 

       250        260        270        280        290 
HFPAITSWSQ IVPRLSSKGR DLLQKLLVCR PNQRVSAEQA MQHPYFTDSS NH 

« Hide

References

[1]"Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans."
Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.
Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fat body.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ307184 mRNA. Translation: ABC25084.1.

3D structure databases

ProteinModelPortalQ2PQN9.
SMRQ2PQN9. Positions 1-288.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ2PQN9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK5_GLOMM
AccessionPrimary (citable) accession number: Q2PQN9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: October 16, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families