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Q2PQN9

- CDK5_GLOMM

UniProt

Q2PQN9 - CDK5_GLOMM

Protein

Cyclin-dependent kinase 5 homolog

Gene

Cdk5

Organism
Glossina morsitans morsitans (Savannah tsetse fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 5
    Gene namesi
    Name:Cdk5
    OrganismiGlossina morsitans morsitans (Savannah tsetse fly)
    Taxonomic identifieri37546 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent kinase 5 homologPRO_0000291621Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei159 – 1591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2PQN9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2PQN9.
    SMRiQ2PQN9. Positions 1-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2PQN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYEKLEKI GEGTYGTVFK GRNRETLEIV ALKRVRLDED DEGVPSSALR    50
    EICLLKELKH KNIVRLYDVL HSEKKLTLVF EHCDQDLKKY FDSLNGDIDM 100
    AVCRSFMLQL LRGLAFCHSH NVLHRDLKPQ NLLINKNGEL KLADFGLARA 150
    FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT TSIDMWSAGC IFAELADAGR 200
    PLFPGSDVLD QLMKIFRVLG TPTEESWPGV THLSDYVALP HFPAITSWSQ 250
    IVPRLSSKGR DLLQKLLVCR PNQRVSAEQA MQHPYFTDSS NH 292
    Length:292
    Mass (Da):33,206
    Last modified:January 24, 2006 - v1
    Checksum:i8BE6A37641CF9ED8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ307184 mRNA. Translation: ABC25084.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ307184 mRNA. Translation: ABC25084.1 .

    3D structure databases

    ProteinModelPortali Q2PQN9.
    SMRi Q2PQN9. Positions 1-288.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2PQN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans."
      Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.
      Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fat body.

    Entry informationi

    Entry nameiCDK5_GLOMM
    AccessioniPrimary (citable) accession number: Q2PQN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3