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Protein

Cyclin-dependent kinase 5 homolog

Gene

Cdk5

Organism
Glossina morsitans morsitans (Savannah tsetse fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 5
Gene namesi
Name:Cdk5
OrganismiGlossina morsitans morsitans (Savannah tsetse fly)
Taxonomic identifieri37546 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina
Proteomesi
  • UP000092444 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002916211 – 292Cyclin-dependent kinase 5 homologAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2PQN9.

Structurei

3D structure databases

ProteinModelPortaliQ2PQN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2PQN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYEKLEKI GEGTYGTVFK GRNRETLEIV ALKRVRLDED DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLYDVL HSEKKLTLVF EHCDQDLKKY FDSLNGDIDM
110 120 130 140 150
AVCRSFMLQL LRGLAFCHSH NVLHRDLKPQ NLLINKNGEL KLADFGLARA
160 170 180 190 200
FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT TSIDMWSAGC IFAELADAGR
210 220 230 240 250
PLFPGSDVLD QLMKIFRVLG TPTEESWPGV THLSDYVALP HFPAITSWSQ
260 270 280 290
IVPRLSSKGR DLLQKLLVCR PNQRVSAEQA MQHPYFTDSS NH
Length:292
Mass (Da):33,206
Last modified:January 24, 2006 - v1
Checksum:i8BE6A37641CF9ED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ307184 mRNA. Translation: ABC25084.1.

Genome annotation databases

VectorBaseiGMOY000139-RA; GMOY000139-PA; GMOY000139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ307184 mRNA. Translation: ABC25084.1.

3D structure databases

ProteinModelPortaliQ2PQN9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2PQN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

VectorBaseiGMOY000139-RA; GMOY000139-PA; GMOY000139.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK5_GLOMM
AccessioniPrimary (citable) accession number: Q2PQN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: October 5, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.