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Q2PQH8

- GDE_CANFA

UniProt

Q2PQH8 - GDE_CANFA

Protein

Glycogen debranching enzyme

Gene

AGL

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.By similarity

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
    Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei527 – 5271By similarity
    Active sitei530 – 5301By similarity
    Active sitei628 – 6281By similarity

    GO - Molecular functioni

    1. 4-alpha-glucanotransferase activity Source: RefGenome
    2. amylo-alpha-1,6-glucosidase activity Source: RefGenome

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-KW
    2. glycogen catabolic process Source: RefGenome

    Keywords - Molecular functioni

    Glycosidase, Glycosyltransferase, Hydrolase, Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen debranching enzyme
    Alternative name(s):
    Glycogen debrancher
    Including the following 2 domains:
    4-alpha-glucanotransferase (EC:2.4.1.25)
    Alternative name(s):
    Oligo-1,4-1,4-glucantransferase
    Amylo-alpha-1,6-glucosidase (EC:3.2.1.33)
    Short name:
    Amylo-1,6-glucosidase
    Alternative name(s):
    Dextrin 6-alpha-D-glucosidase
    Gene namesi
    Name:AGL
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Cytoplasm By similarity
    Note: Under glycogenolytic conditions localizes to the nucleus.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Keywords - Diseasei

    Glycogen storage disease

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15331533Glycogen debranching enzymePRO_0000232710Add
    BLAST

    Post-translational modificationi

    Ubiquitinated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ2PQH8.

    Interactioni

    Subunit structurei

    Monomer. Interacts with NHLRC1/malin By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000029699.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2PQH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni? – 1533Amylo-1,6-glucosidase
    Regioni1 – ?4-alpha-glucanotransferase

    Sequence similaritiesi

    Belongs to the glycogen debranching enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG3408.
    HOGENOMiHOG000212981.
    HOVERGENiHBG005824.
    InParanoidiQ2PQH8.
    KOiK01196.

    Family and domain databases

    Gene3Di3.20.20.80. 5 hits.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR010401. AGL/Gdb1.
    IPR029436. AGL_euk_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR006421. Glycogen_debranch_met.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10569. PTHR10569. 1 hit.
    PfamiPF06202. GDE_C. 1 hit.
    PF14699. hGDE_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 2 hits.
    SSF51445. SSF51445. 2 hits.
    TIGRFAMsiTIGR01531. glyc_debranch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2PQH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHSKQIRIL LLNEMEKLEK TLFRLEQGFE LQFRLGPTLQ GKAVTVYTNY     50
    PFPGETFNRE KFRSLEWENP TEREDDSDKY CKLNLQQAGS FQYYFLQGNE 100
    KSGGGYIVVD PILYVGADNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA 150
    KESGYNMIHF TPLQTLGLSR SCYSLANQLE LNPDFSRPNK KYTWSDVGQL 200
    VEKMKKEWNV LCITDVVYNH TAANSKWIQE HPESAYNLVN SPHLKPAWVL 250
    DRALWHLSCD VAEGKYKEKG VPALIENDHQ MNCIRKIIWE DIFPKIQLWE 300
    FFQVDVYKAV EQFRRLLTQE NRKITTKPDP KEHLKIIQDP EYRRLGCTVD 350
    MNIALATFIP HDKGPAAIDE CCNWFRKRIE ELNSEKHQLV NYHQEQAVNC 400
    LLGNVFYERM AGHGPKLGPV TRKHPLVTRY FTFPFEEMTV STEESMIHNP 450
    NKACFLMAHN GWVMGDDPLR NFAEPGSEVY LRRELICWGD SVKLRYGNKP 500
    EDCPYLWAHM KKYTEITATY FQGVRLDNCH STPLHVAEYM LDAARKLQPN 550
    LYVVAELFTG SEDLDNIFVT RLGISSLIRE AMSAYNSHEE GRLVYRYGGE 600
    PVGSFVQPCL RPLMPAIAHA LFMDITHDNE CPIVHRSEYD ALPSTTIVSM 650
    ACCASGSTKG YDELVPHQIS VVSEERFYTK WNPGASPSNT GEVNFQSGII 700
    AARCAINKLH QELGAQGFIQ VYVDQVDEDI VAVTRHSPSI HQSVVSVSRT 750
    AFRNPKTSFY SKEVPQMCIP GKIEEVVLEA RTIERNTKPY QKDKNSINGM 800
    PNITVEIREH IQLSESKIVK QAGVATKGPN EYIQEIEFEN LSPGSVIIFR 850
    VSLDPHAQVA VGILRNHLTQ FSPHFKSGSL AVENSDPILK IPFAFIASKL 900
    TLAELNQVLY RCEAEEQEDG GGCYDIPNWS SLKYAGLQGL MSVLAEIRPK 950
    NDLGHPFCDN LRSGDWMIDY VSNRLISRSG TIAEVGKWFQ AMFFYLKQIP 1000
    RYLIPCYFDA ILIGAYTTLL DIAWKQMSSF VQNGSTFVKH LSLGSVQMCG 1050
    VGKCPSLPLL SPSLMDVPYR LNEITKEKEQ CCVSLAAGLP HFSSGIFRCW 1100
    GRDTFIALRG LLLITGRYLE ARNIILAFAG TLRHGLIPNL LGEGTYARYN 1150
    CRDAVWWWLQ CIQDYCKMVP NGLDILKCPV SRMYPTDDSV PLSAGTLDQP 1200
    LFEVIQEVMQ RHIQGIQFRE RNAGPQIDRN MKDEGFNITA GVDEETGFVY 1250
    GGNRLNCGTW MDKMGESDRA RNRGIPATPR DGSAVEIVGL SKSTVRWLLE 1300
    LSKKRIFPYH EVRVKRHGKV VTISYDEWNK KIQDNFEKLF HVSEDPXDFN 1350
    EKHPNLVHKR GIYKDSYGAS SPWCDYQLRP NFTIAMVVAP ELFTAEKAWK 1400
    ALEIAEKKLL GPLGMKTLDP DDMVYCGIYD NALDNDNYNL AKGFNYHQGP 1450
    EWLWPVGYFL RAKLYFSKLM GPEANAKTVF LVKNILSRHY VHLERSPWKG 1500
    LPELTNENGQ YCPFSCETQA WSIATVLETL YDL 1533
    Length:1,533
    Mass (Da):174,828
    Last modified:January 24, 2006 - v1
    Checksum:i8A6E8A11F2252087
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ307574 mRNA. Translation: ABC25005.1.
    RefSeqiNP_001041561.1. NM_001048096.1.
    UniGeneiCfa.18682.

    Genome annotation databases

    GeneIDi479931.
    KEGGicfa:479931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ307574 mRNA. Translation: ABC25005.1 .
    RefSeqi NP_001041561.1. NM_001048096.1.
    UniGenei Cfa.18682.

    3D structure databases

    ProteinModelPortali Q2PQH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000029699.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    Proteomic databases

    PaxDbi Q2PQH8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 479931.
    KEGGi cfa:479931.

    Organism-specific databases

    CTDi 178.

    Phylogenomic databases

    eggNOGi COG3408.
    HOGENOMi HOG000212981.
    HOVERGENi HBG005824.
    InParanoidi Q2PQH8.
    KOi K01196.

    Miscellaneous databases

    NextBioi 20855039.

    Family and domain databases

    Gene3Di 3.20.20.80. 5 hits.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR010401. AGL/Gdb1.
    IPR029436. AGL_euk_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR006421. Glycogen_debranch_met.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10569. PTHR10569. 1 hit.
    Pfami PF06202. GDE_C. 1 hit.
    PF14699. hGDE_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 2 hits.
    SSF51445. SSF51445. 2 hits.
    TIGRFAMsi TIGR01531. glyc_debranch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Glycogen storage disease type IIIa in curly-coated retrievers."
      Gregory B.L., Shelton G.D., Bali D.S., Chen Y.T., Fyfe J.C.
      J. Vet. Intern. Med. 21:40-46(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGDE_CANFA
    AccessioniPrimary (citable) accession number: Q2PQH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3