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Q2PQH8

- GDE_CANFA

UniProt

Q2PQH8 - GDE_CANFA

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Protein
Glycogen debranching enzyme
Gene
AGL
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation By similarity.

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei527 – 5271 By similarity
Active sitei530 – 5301 By similarity
Active sitei628 – 6281 By similarity

GO - Molecular functioni

  1. 4-alpha-glucanotransferase activity Source: RefGenome
  2. amylo-alpha-1,6-glucosidase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-KW
  2. glycogen catabolic process Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Glycosyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen debranching enzyme
Alternative name(s):
Glycogen debrancher
Including the following 2 domains:
4-alpha-glucanotransferase (EC:2.4.1.25)
Alternative name(s):
Oligo-1,4-1,4-glucantransferase
Amylo-alpha-1,6-glucosidase (EC:3.2.1.33)
Short name:
Amylo-1,6-glucosidase
Alternative name(s):
Dextrin 6-alpha-D-glucosidase
Gene namesi
Name:AGL
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Cytoplasm By similarity
Note: Under glycogenolytic conditions localizes to the nucleus By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Glycogen storage disease

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15331533Glycogen debranching enzyme
PRO_0000232710Add
BLAST

Post-translational modificationi

Ubiquitinated By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ2PQH8.

Interactioni

Subunit structurei

Monomer. Interacts with NHLRC1/malin By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029699.

Structurei

3D structure databases

ProteinModelPortaliQ2PQH8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni? – 1533Amylo-1,6-glucosidase
Regioni1 – ?4-alpha-glucanotransferase

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3408.
HOGENOMiHOG000212981.
HOVERGENiHBG005824.
InParanoidiQ2PQH8.
KOiK01196.

Family and domain databases

Gene3Di3.20.20.80. 5 hits.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR010401. AGL/Gdb1.
IPR029436. AGL_euk_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR006421. Glycogen_debranch_met.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10569. PTHR10569. 1 hit.
PfamiPF06202. GDE_C. 1 hit.
PF14699. hGDE_N. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 2 hits.
SSF51445. SSF51445. 2 hits.
TIGRFAMsiTIGR01531. glyc_debranch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2PQH8-1 [UniParc]FASTAAdd to Basket

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MGHSKQIRIL LLNEMEKLEK TLFRLEQGFE LQFRLGPTLQ GKAVTVYTNY     50
PFPGETFNRE KFRSLEWENP TEREDDSDKY CKLNLQQAGS FQYYFLQGNE 100
KSGGGYIVVD PILYVGADNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA 150
KESGYNMIHF TPLQTLGLSR SCYSLANQLE LNPDFSRPNK KYTWSDVGQL 200
VEKMKKEWNV LCITDVVYNH TAANSKWIQE HPESAYNLVN SPHLKPAWVL 250
DRALWHLSCD VAEGKYKEKG VPALIENDHQ MNCIRKIIWE DIFPKIQLWE 300
FFQVDVYKAV EQFRRLLTQE NRKITTKPDP KEHLKIIQDP EYRRLGCTVD 350
MNIALATFIP HDKGPAAIDE CCNWFRKRIE ELNSEKHQLV NYHQEQAVNC 400
LLGNVFYERM AGHGPKLGPV TRKHPLVTRY FTFPFEEMTV STEESMIHNP 450
NKACFLMAHN GWVMGDDPLR NFAEPGSEVY LRRELICWGD SVKLRYGNKP 500
EDCPYLWAHM KKYTEITATY FQGVRLDNCH STPLHVAEYM LDAARKLQPN 550
LYVVAELFTG SEDLDNIFVT RLGISSLIRE AMSAYNSHEE GRLVYRYGGE 600
PVGSFVQPCL RPLMPAIAHA LFMDITHDNE CPIVHRSEYD ALPSTTIVSM 650
ACCASGSTKG YDELVPHQIS VVSEERFYTK WNPGASPSNT GEVNFQSGII 700
AARCAINKLH QELGAQGFIQ VYVDQVDEDI VAVTRHSPSI HQSVVSVSRT 750
AFRNPKTSFY SKEVPQMCIP GKIEEVVLEA RTIERNTKPY QKDKNSINGM 800
PNITVEIREH IQLSESKIVK QAGVATKGPN EYIQEIEFEN LSPGSVIIFR 850
VSLDPHAQVA VGILRNHLTQ FSPHFKSGSL AVENSDPILK IPFAFIASKL 900
TLAELNQVLY RCEAEEQEDG GGCYDIPNWS SLKYAGLQGL MSVLAEIRPK 950
NDLGHPFCDN LRSGDWMIDY VSNRLISRSG TIAEVGKWFQ AMFFYLKQIP 1000
RYLIPCYFDA ILIGAYTTLL DIAWKQMSSF VQNGSTFVKH LSLGSVQMCG 1050
VGKCPSLPLL SPSLMDVPYR LNEITKEKEQ CCVSLAAGLP HFSSGIFRCW 1100
GRDTFIALRG LLLITGRYLE ARNIILAFAG TLRHGLIPNL LGEGTYARYN 1150
CRDAVWWWLQ CIQDYCKMVP NGLDILKCPV SRMYPTDDSV PLSAGTLDQP 1200
LFEVIQEVMQ RHIQGIQFRE RNAGPQIDRN MKDEGFNITA GVDEETGFVY 1250
GGNRLNCGTW MDKMGESDRA RNRGIPATPR DGSAVEIVGL SKSTVRWLLE 1300
LSKKRIFPYH EVRVKRHGKV VTISYDEWNK KIQDNFEKLF HVSEDPXDFN 1350
EKHPNLVHKR GIYKDSYGAS SPWCDYQLRP NFTIAMVVAP ELFTAEKAWK 1400
ALEIAEKKLL GPLGMKTLDP DDMVYCGIYD NALDNDNYNL AKGFNYHQGP 1450
EWLWPVGYFL RAKLYFSKLM GPEANAKTVF LVKNILSRHY VHLERSPWKG 1500
LPELTNENGQ YCPFSCETQA WSIATVLETL YDL 1533
Length:1,533
Mass (Da):174,828
Last modified:January 24, 2006 - v1
Checksum:i8A6E8A11F2252087
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ307574 mRNA. Translation: ABC25005.1.
RefSeqiNP_001041561.1. NM_001048096.1.
UniGeneiCfa.18682.

Genome annotation databases

GeneIDi479931.
KEGGicfa:479931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ307574 mRNA. Translation: ABC25005.1 .
RefSeqi NP_001041561.1. NM_001048096.1.
UniGenei Cfa.18682.

3D structure databases

ProteinModelPortali Q2PQH8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000029699.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Proteomic databases

PaxDbi Q2PQH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 479931.
KEGGi cfa:479931.

Organism-specific databases

CTDi 178.

Phylogenomic databases

eggNOGi COG3408.
HOGENOMi HOG000212981.
HOVERGENi HBG005824.
InParanoidi Q2PQH8.
KOi K01196.

Miscellaneous databases

NextBioi 20855039.

Family and domain databases

Gene3Di 3.20.20.80. 5 hits.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR010401. AGL/Gdb1.
IPR029436. AGL_euk_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR006421. Glycogen_debranch_met.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10569. PTHR10569. 1 hit.
Pfami PF06202. GDE_C. 1 hit.
PF14699. hGDE_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48208. SSF48208. 2 hits.
SSF51445. SSF51445. 2 hits.
TIGRFAMsi TIGR01531. glyc_debranch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Glycogen storage disease type IIIa in curly-coated retrievers."
    Gregory B.L., Shelton G.D., Bali D.S., Chen Y.T., Fyfe J.C.
    J. Vet. Intern. Med. 21:40-46(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGDE_CANFA
AccessioniPrimary (citable) accession number: Q2PQH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi