Heme oxygenase 2 - Macaca fascicularis (Crab-eating macaque)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Heme oxygenase 2
Short name=HO-2
EC=1.14.99.3

Gene names

Name:	HMOX2
ORF Names:	QbsB-11392

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter By similarity.
Catalytic activity	Heme + 3 AH₂ + 3 O₂ = biliverdin + Fe²⁺ + CO + 3 A + 3 H₂O.
Subcellular location	Microsome. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological_process	heme oxidation Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 316

315

Heme oxygenase 2

PRO_0000317708

Regions

Repeat

264 – 269

6

HRM 1

Repeat

281 – 286

6

HRM 2

Sites

Metal binding

45

1

Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue

2

1

N-acetylserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q2PG53 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 40A85866272B219E
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FASTA

316

36,081

        10         20         30         40         50         60 
MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG 

        70         80         90        100        110        120 
NIKKELFKLA TTALYFTYSA LEEEMERNKD HPTFAPLYFP MELHRKEALT KDMEYFFGEN 

       130        140        150        160        170        180 
WEEQVQCPKA AKKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST 

       190        200        210        220        230        240 
GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA 

       250        260        270        280        290        300 
GSTLARETLE DGFPVHDGKG DMRKCPFYAG EQDKGALEGS SCPFRTAMAV LRKPSLQFIL 

       310 
AAGMALAAGL LAWYYM

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References

[1]	"Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA oligo-chips." Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S., Hashimoto K. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain stem.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB220384 mRNA. Translation: BAE72917.1.
3D structure databases
HSSP	HSSP built from PDB template 1WZD based on UniProtKB Q54AI1.
ProteinModelPortal	Q2PG53.
SMR	Q2PG53. Positions 30-248.
ModBase	Search...
Proteomic databases
PRIDE	Q2PG53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005982.
Family and domain databases
Gene3D	1.20.910.10. 1 hit.
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
PANTHER	PTHR10720. PTHR10720. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMOX2_MACFA

Accession

Primary (citable) accession number: Q2PG53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	March 6, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families