Q2PFX0 (ATE1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginyl-tRNA--protein transferase 1
Short name=Arginyltransferase 1
Short name=R-transferase 1
EC=2.3.2.8

Alternative name(s):
Arginine-tRNA--protein transferase 1

Gene names

Name:	ATE1
ORF Names:	QflA-16011

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues By similarity.
Catalytic activity	L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
Subunit structure	Monomer Potential.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the R-transferase family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein arginylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Arginyl-tRNA--protein transferase 1		PRO_0000351081
Amino acid modifications
	Modified residue	169	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2PFX0 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 7CAA62C5CB5F3264	FASTA	518	59,014
	10 20 30 40 50 60 MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL IDRGWRRSGK 70 80 90 100 110 120 YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF LAKGEVPKGS CEDEPMDSTM 130 140 150 160 170 180 DDAVAGDFAL INKLDIQCDL KTLSDDVKES LQSEGKNSKK EEPHELLQSQ DSVGEKLGSG 190 200 210 220 230 240 EPSHSVKVHT VPKPGKGADL SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS 250 260 270 280 290 300 LFPPKAKSNQ PKSLEDLIFE SLPENASHKL EVRLVPASFE DPEFKSSFSQ SFSLYVKYQV 310 320 330 340 350 360 AIHQDLPDEC GKTEFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI IAVGVIDILP 370 380 390 400 410 420 NYVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ LSYYYMGFYI HSCPKMKYKG 430 440 450 460 470 480 QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM 490 500 510 PYGVYKKQQK DPSEEAAVLQ YASLVGQKCS ERMLLFRN

References

[1]	"Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA oligo-chips." Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S., Hashimoto K. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Frontal cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB220467 mRNA. Translation: BAE73000.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q2PFX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004299.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR017137. Arg-tRNA-P_Trfase_1_euk. IPR007472. Arg-tRNA-P_Trfase_C. IPR007471. Arg_tRNA_PTrfase_N. [Graphical view]
Pfam	PF04377. ATE_C. 1 hit. PF04376. ATE_N. 1 hit. [Graphical view]
PIRSF	PIRSF037207. ATE1_euk. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ATE1_MACFA

Accession

Primary (citable) accession number: Q2PFX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	February 7, 2006
Last modified:	October 19, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program