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Q2PFM2 (NAA20_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 20
EC=2.3.1.88
Alternative name(s):
Methionine N-acetyltransferase
N-acetyltransferase 5
N-terminal acetyltransferase B complex catalytic subunit NAA20
N-terminal acetyltransferase B complex catalytic subunit NAT5
Short name=NatB complex subunit NAT5
NatB catalytic subunit
Gene names
Name:NAA20
Synonyms:NAT5
ORF Names:QtrA-15925
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration By similarity.

Catalytic activity

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

Subunit structure

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the acetyltransferase family. ARD1 subfamily.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptide alpha-N-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178N-alpha-acetyltransferase 20
PRO_0000249840

Regions

Domain2 – 157156N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q2PFM2 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: C5CCEA50CD60E097

FASTA17820,368
        10         20         30         40         50         60 
MTTLRAFTCD DLFRFNNINL DPLTETYGIP FYLQYLAHWP EYFIVAEAPG GELMGYIMGK 

        70         80         90        100        110        120 
AEGSVAREEW HGHVTALSVA PEFRRLGLAA KLMELLEEIS ERKGGFFVDL FVRVSNQVAV 

       130        140        150        160        170 
NMYKQLGYSV YRTVIEYYSA SNGEPDEDAY DMRKALSRDT EKKSIIPLPH PVRPEDIE

« Hide

References

[1]"Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA oligo-chips."
Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S., Hashimoto K.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Temporal cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB220565 mRNA. Translation: BAE73098.1.

3D structure databases

ProteinModelPortalQ2PFM2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG107217.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAA20_MACFA
AccessionPrimary (citable) accession number: Q2PFM2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 7, 2006
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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