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Q2PDF6

- RTPR_EUGGR

UniProt

Q2PDF6 - RTPR_EUGGR

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rnr

Organism
Euglena gracilis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.1 Publication

    Cofactori

    Adenosylcobalamin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei427 – 4271By similarity
    Active sitei429 – 4291By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    SABIO-RKQ2PDF6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rnr
    OrganismiEuglena gracilis
    Taxonomic identifieri3039 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi189 ↔ 438Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Sequencei

    Sequence statusi: Complete.

    Q2PDF6-1 [UniParc]FASTAAdd to Basket

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    MAEKENVHPQ VISSFPTPSK ALKLSEKSSL KDVQTDNAAV PLVVDETSYP    50
    EPTCEFYGGL LGPQLPEAER FVLDPALVEE YRHKKPPFGF NGLGEVVYLR 100
    TYAREKDNGQ SEVWLDTVQR VVTGTFEVLQ HHVVNKLHCH WDAQKAKERS 150
    EDMFRRIFEM KFLPPGRGLW AMGSPICRKK GFAAALNNCA FVSTATLEKD 200
    RVGPFLFLMD ASMLGVGVGF DNAGAGSFTV PGPDDTQPTY KFMIPDKREG 250
    WVESLKRLLK AHFCHTADVE FDYSKIREMG TKLKTFGGTS SGPGPLINLH 300
    KSIRKILVGE KGKPISVTCI TDIMNLIGVC TVAGNIRRSA EIAFGEADCK 350
    EFLDLKSYET NPHRVEYGWA SNNSIFAKVG MDYSDACERV RTNGEPGFAW 400
    LSNMQAFSRM NGKPDYRDQR VLGGNPCLEQ SLESMELCCL VETFPDKHET 450
    LEDFKRTLYS ALLYAKTVTL LPLHWRESNE IMLRNRRIGC SVSGIAQFIT 500
    NRGLHELKTW LEEGYDILHQ YDCQISEWLC IRQSIKLTSV KPSGTISLVA 550
    GATPGVHYPE SCYYTRRLRM ARDSPLLERL IKAGYHVEPC CVAPDVTAIV 600
    EFPVAAGNSI RTTRDITMWE QLSLAAFMQR YWADNQVSAT ITFDPETEGL 650
    HLNQALQYFQ YQLKGISFLP RYPMGAFKQM PYEAITKEQY EEAIRKVKED 700
    VSLSSANAIA ETVEENQQTF CDNDRCIKL 729
    Length:729
    Mass (Da):82,175
    Last modified:February 7, 2006 - v1
    Checksum:i91F4F84D8B2E297C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ620503 mRNA. Translation: CAF05662.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ620503 mRNA. Translation: CAF05662.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK Q2PDF6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Euglena gracilis ribonucleotide reductase: the eukaryote class II enzyme and the possible antiquity of eukaryote B12 dependence."
      Torrents E., Trevisiol C., Rotte C., Hellman U., Martin W., Reichard P.
      J. Biol. Chem. 281:5604-5611(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
      Strain: SAG 1224-5/25.

    Entry informationi

    Entry nameiRTPR_EUGGR
    AccessioniPrimary (citable) accession number: Q2PDF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3