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Q2PDF6

- RTPR_EUGGR

UniProt

Q2PDF6 - RTPR_EUGGR

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rnr

Organism
Euglena gracilis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.1 Publication

Cofactori

adenosylcob(III)alamin1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei427 – 4271By similarity
Active sitei429 – 4291By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

SABIO-RKQ2PDF6.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rnr
OrganismiEuglena gracilis
Taxonomic identifieri3039 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi189 ↔ 438Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Sequencei

Sequence statusi: Complete.

Q2PDF6-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAEKENVHPQ VISSFPTPSK ALKLSEKSSL KDVQTDNAAV PLVVDETSYP
60 70 80 90 100
EPTCEFYGGL LGPQLPEAER FVLDPALVEE YRHKKPPFGF NGLGEVVYLR
110 120 130 140 150
TYAREKDNGQ SEVWLDTVQR VVTGTFEVLQ HHVVNKLHCH WDAQKAKERS
160 170 180 190 200
EDMFRRIFEM KFLPPGRGLW AMGSPICRKK GFAAALNNCA FVSTATLEKD
210 220 230 240 250
RVGPFLFLMD ASMLGVGVGF DNAGAGSFTV PGPDDTQPTY KFMIPDKREG
260 270 280 290 300
WVESLKRLLK AHFCHTADVE FDYSKIREMG TKLKTFGGTS SGPGPLINLH
310 320 330 340 350
KSIRKILVGE KGKPISVTCI TDIMNLIGVC TVAGNIRRSA EIAFGEADCK
360 370 380 390 400
EFLDLKSYET NPHRVEYGWA SNNSIFAKVG MDYSDACERV RTNGEPGFAW
410 420 430 440 450
LSNMQAFSRM NGKPDYRDQR VLGGNPCLEQ SLESMELCCL VETFPDKHET
460 470 480 490 500
LEDFKRTLYS ALLYAKTVTL LPLHWRESNE IMLRNRRIGC SVSGIAQFIT
510 520 530 540 550
NRGLHELKTW LEEGYDILHQ YDCQISEWLC IRQSIKLTSV KPSGTISLVA
560 570 580 590 600
GATPGVHYPE SCYYTRRLRM ARDSPLLERL IKAGYHVEPC CVAPDVTAIV
610 620 630 640 650
EFPVAAGNSI RTTRDITMWE QLSLAAFMQR YWADNQVSAT ITFDPETEGL
660 670 680 690 700
HLNQALQYFQ YQLKGISFLP RYPMGAFKQM PYEAITKEQY EEAIRKVKED
710 720
VSLSSANAIA ETVEENQQTF CDNDRCIKL
Length:729
Mass (Da):82,175
Last modified:February 7, 2006 - v1
Checksum:i91F4F84D8B2E297C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ620503 mRNA. Translation: CAF05662.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ620503 mRNA. Translation: CAF05662.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK Q2PDF6.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Euglena gracilis ribonucleotide reductase: the eukaryote class II enzyme and the possible antiquity of eukaryote B12 dependence."
    Torrents E., Trevisiol C., Rotte C., Hellman U., Martin W., Reichard P.
    J. Biol. Chem. 281:5604-5611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
    Strain: SAG 1224-5/25.

Entry informationi

Entry nameiRTPR_EUGGR
AccessioniPrimary (citable) accession number: Q2PDF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3