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Q2PC20 (PPM1K_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1K, mitochondrial

EC=3.1.3.16
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name=PP2C-kappa
Gene names
Name:PPM1K
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2PC20-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2PC20-2)

The sequence of this isoform differs from the canonical sequence as follows:
     106-153: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion By similarity
Chain30 – 372343Protein phosphatase 1K, mitochondrial
PRO_0000278207

Regions

Domain93 – 346254PP2C-like

Sites

Metal binding1271Magnesium By similarity
Metal binding1281Magnesium; via carbonyl oxygen By similarity
Metal binding3371Magnesium By similarity

Amino acid modifications

Modified residue2481Phosphoserine By similarity

Natural variations

Alternative sequence106 – 15348Missing in isoform 2.
VSP_023155

Experimental info

Sequence conflict3651F → I in AAI18080. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 5A8536B6E2F78090

FASTA37241,151
        10         20         30         40         50         60 
MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF DPDGSGRPAT 

        70         80         90        100        110        120 
WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ IGKRKENEDR FGFAQLTNEV 

       130        140        150        160        170        180 
LYFAVYDGHG GPAAADFCHT HMEKCILDLL PKEENLETVL TLAFLEIDKT FARHAHLSAD 

       190        200        210        220        230        240 
ATLLTSGTTA TVALLRDGIE LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 

       250        260        270        280        290        300 
GGFVAWNSLG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 

       310        320        330        340        350        360 
NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG KYKNSEITFS 

       370 
FSRSFASSGR WA 

« Hide

Isoform 2 [UniParc].

Checksum: 452CFAA721E6D8B8
Show »

FASTA32435,755

References

« Hide 'large scale' references
[1]Seroussi E.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: Holstein.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ871967 mRNA. Translation: CAI44748.1.
AJ871968 mRNA. Translation: CAI44749.1.
BC118079 mRNA. Translation: AAI18080.1.
RefSeqNP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.1.
UniGeneBt.48380.

3D structure databases

ProteinModelPortalQ2PC20.
SMRQ2PC20. Positions 90-349.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
GeneID540329.
KEGGbta:540329.

Organism-specific databases

CTD152926.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00740000114971.
HOGENOMHOG000059620.
HOVERGENHBG096199.
InParanoidQ2PC20.
KOK17505.
OMADTFGIWD.
OrthoDBEOG7992QN.
TreeFamTF354344.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20878566.

Entry information

Entry namePPM1K_BOVIN
AccessionPrimary (citable) accession number: Q2PC20
Secondary accession number(s): Q17R15, Q2PC19
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 7, 2006
Last modified: March 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families