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Q2PC20

- PPM1K_BOVIN

UniProt

Q2PC20 - PPM1K_BOVIN

Protein

Protein phosphatase 1K, mitochondrial

Gene

PPM1K

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271MagnesiumBy similarity
    Metal bindingi128 – 1281Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi337 – 3371MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 2C isoform kappa
    Short name:
    PP2C-kappa
    Gene namesi
    Name:PPM1K
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionBy similarityAdd
    BLAST
    Chaini30 – 372343Protein phosphatase 1K, mitochondrialPRO_0000278207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ2PC20.
    SMRiQ2PC20. Positions 90-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 346254PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000059620.
    HOVERGENiHBG096199.
    InParanoidiQ2PC20.
    KOiK17505.
    OMAiIVPFGAW.
    OrthoDBiEOG7992QN.
    TreeFamiTF354344.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2PC20-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF    50
    DPDGSGRPAT WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ 100
    IGKRKENEDR FGFAQLTNEV LYFAVYDGHG GPAAADFCHT HMEKCILDLL 150
    PKEENLETVL TLAFLEIDKT FARHAHLSAD ATLLTSGTTA TVALLRDGIE 200
    LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC GGFVAWNSLG 250
    QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300
    NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG 350
    KYKNSEITFS FSRSFASSGR WA 372
    Length:372
    Mass (Da):41,151
    Last modified:February 7, 2006 - v1
    Checksum:i5A8536B6E2F78090
    GO
    Isoform 2 (identifier: Q2PC20-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         106-153: Missing.

    Show »
    Length:324
    Mass (Da):35,755
    Checksum:i452CFAA721E6D8B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti365 – 3651F → I in AAI18080. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei106 – 15348Missing in isoform 2. 1 PublicationVSP_023155Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ871967 mRNA. Translation: CAI44748.1.
    AJ871968 mRNA. Translation: CAI44749.1.
    BC118079 mRNA. Translation: AAI18080.1.
    RefSeqiNP_001039939.1. NM_001046474.2.
    XP_005207855.1. XM_005207798.1. [Q2PC20-1]
    UniGeneiBt.48380.

    Genome annotation databases

    EnsembliENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
    GeneIDi540329.
    KEGGibta:540329.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ871967 mRNA. Translation: CAI44748.1 .
    AJ871968 mRNA. Translation: CAI44749.1 .
    BC118079 mRNA. Translation: AAI18080.1 .
    RefSeqi NP_001039939.1. NM_001046474.2.
    XP_005207855.1. XM_005207798.1. [Q2PC20-1 ]
    UniGenei Bt.48380.

    3D structure databases

    ProteinModelPortali Q2PC20.
    SMRi Q2PC20. Positions 90-349.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000007563 ; ENSBTAP00000007563 ; ENSBTAG00000005754 . [Q2PC20-1 ]
    GeneIDi 540329.
    KEGGi bta:540329.

    Organism-specific databases

    CTDi 152926.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000059620.
    HOVERGENi HBG096199.
    InParanoidi Q2PC20.
    KOi K17505.
    OMAi IVPFGAW.
    OrthoDBi EOG7992QN.
    TreeFami TF354344.

    Miscellaneous databases

    NextBioi 20878566.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Seroussi E.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: Holstein.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiPPM1K_BOVIN
    AccessioniPrimary (citable) accession number: Q2PC20
    Secondary accession number(s): Q17R15, Q2PC19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3