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Q2PC20

- PPM1K_BOVIN

UniProt

Q2PC20 - PPM1K_BOVIN

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Protein
Protein phosphatase 1K, mitochondrial
Gene
PPM1K
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271Magnesium By similarity
Metal bindingi128 – 1281Magnesium; via carbonyl oxygen By similarity
Metal bindingi337 – 3371Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:PPM1K
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion By similarity
Add
BLAST
Chaini30 – 372343Protein phosphatase 1K, mitochondrial
PRO_0000278207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2PC20.
SMRiQ2PC20. Positions 90-349.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 346254PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ2PC20.
KOiK17505.
OMAiIVPFGAW.
OrthoDBiEOG7992QN.
TreeFamiTF354344.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2PC20-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF    50
DPDGSGRPAT WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ 100
IGKRKENEDR FGFAQLTNEV LYFAVYDGHG GPAAADFCHT HMEKCILDLL 150
PKEENLETVL TLAFLEIDKT FARHAHLSAD ATLLTSGTTA TVALLRDGIE 200
LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC GGFVAWNSLG 250
QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300
NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG 350
KYKNSEITFS FSRSFASSGR WA 372
Length:372
Mass (Da):41,151
Last modified:February 7, 2006 - v1
Checksum:i5A8536B6E2F78090
GO
Isoform 2 (identifier: Q2PC20-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-153: Missing.

Show »
Length:324
Mass (Da):35,755
Checksum:i452CFAA721E6D8B8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 15348Missing in isoform 2.
VSP_023155Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti365 – 3651F → I in AAI18080. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ871967 mRNA. Translation: CAI44748.1.
AJ871968 mRNA. Translation: CAI44749.1.
BC118079 mRNA. Translation: AAI18080.1.
RefSeqiNP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.1. [Q2PC20-1]
UniGeneiBt.48380.

Genome annotation databases

EnsembliENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
GeneIDi540329.
KEGGibta:540329.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ871967 mRNA. Translation: CAI44748.1 .
AJ871968 mRNA. Translation: CAI44749.1 .
BC118079 mRNA. Translation: AAI18080.1 .
RefSeqi NP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.1. [Q2PC20-1 ]
UniGenei Bt.48380.

3D structure databases

ProteinModelPortali Q2PC20.
SMRi Q2PC20. Positions 90-349.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007563 ; ENSBTAP00000007563 ; ENSBTAG00000005754 . [Q2PC20-1 ]
GeneIDi 540329.
KEGGi bta:540329.

Organism-specific databases

CTDi 152926.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000114971.
HOGENOMi HOG000059620.
HOVERGENi HBG096199.
InParanoidi Q2PC20.
KOi K17505.
OMAi IVPFGAW.
OrthoDBi EOG7992QN.
TreeFami TF354344.

Miscellaneous databases

NextBioi 20878566.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Seroussi E.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Holstein.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPPM1K_BOVIN
AccessioniPrimary (citable) accession number: Q2PC20
Secondary accession number(s): Q17R15, Q2PC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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