Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2PC20

- PPM1K_BOVIN

UniProt

Q2PC20 - PPM1K_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein phosphatase 1K, mitochondrial

Gene

PPM1K

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271MagnesiumBy similarity
Metal bindingi128 – 1281Magnesium; via carbonyl oxygenBy similarity
Metal bindingi337 – 3371MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:PPM1K
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionBy similarityAdd
BLAST
Chaini30 – 372343Protein phosphatase 1K, mitochondrialPRO_0000278207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2PC20.
SMRiQ2PC20. Positions 90-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 346254PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ2PC20.
KOiK17505.
OMAiIVPFGAW.
OrthoDBiEOG7992QN.
TreeFamiTF354344.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2PC20-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF
60 70 80 90 100
DPDGSGRPAT WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ
110 120 130 140 150
IGKRKENEDR FGFAQLTNEV LYFAVYDGHG GPAAADFCHT HMEKCILDLL
160 170 180 190 200
PKEENLETVL TLAFLEIDKT FARHAHLSAD ATLLTSGTTA TVALLRDGIE
210 220 230 240 250
LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC GGFVAWNSLG
260 270 280 290 300
QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI
310 320 330 340 350
NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG
360 370
KYKNSEITFS FSRSFASSGR WA
Length:372
Mass (Da):41,151
Last modified:February 7, 2006 - v1
Checksum:i5A8536B6E2F78090
GO
Isoform 2 (identifier: Q2PC20-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-153: Missing.

Show »
Length:324
Mass (Da):35,755
Checksum:i452CFAA721E6D8B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti365 – 3651F → I in AAI18080. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 15348Missing in isoform 2. 1 PublicationVSP_023155Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871967 mRNA. Translation: CAI44748.1.
AJ871968 mRNA. Translation: CAI44749.1.
BC118079 mRNA. Translation: AAI18080.1.
RefSeqiNP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.1. [Q2PC20-1]
UniGeneiBt.48380.

Genome annotation databases

EnsembliENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
GeneIDi540329.
KEGGibta:540329.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871967 mRNA. Translation: CAI44748.1 .
AJ871968 mRNA. Translation: CAI44749.1 .
BC118079 mRNA. Translation: AAI18080.1 .
RefSeqi NP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.1. [Q2PC20-1 ]
UniGenei Bt.48380.

3D structure databases

ProteinModelPortali Q2PC20.
SMRi Q2PC20. Positions 90-349.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007563 ; ENSBTAP00000007563 ; ENSBTAG00000005754 . [Q2PC20-1 ]
GeneIDi 540329.
KEGGi bta:540329.

Organism-specific databases

CTDi 152926.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000114971.
HOGENOMi HOG000059620.
HOVERGENi HBG096199.
InParanoidi Q2PC20.
KOi K17505.
OMAi IVPFGAW.
OrthoDBi EOG7992QN.
TreeFami TF354344.

Miscellaneous databases

NextBioi 20878566.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Seroussi E.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Holstein.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPPM1K_BOVIN
AccessioniPrimary (citable) accession number: Q2PC20
Secondary accession number(s): Q17R15, Q2PC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3