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Protein

Protein phosphatase 1K, mitochondrial

Gene

PPM1K

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Metal bindingi128Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi337MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:PPM1K
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000027820730 – 372Protein phosphatase 1K, mitochondrialAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2PC20.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005754.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007563.

Structurei

3D structure databases

ProteinModelPortaliQ2PC20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 346PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ2PC20.
KOiK17505.
OMAiREFRSAD.
OrthoDBiEOG091G0A0V.
TreeFamiTF354344.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2PC20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF
60 70 80 90 100
DPDGSGRPAT WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ
110 120 130 140 150
IGKRKENEDR FGFAQLTNEV LYFAVYDGHG GPAAADFCHT HMEKCILDLL
160 170 180 190 200
PKEENLETVL TLAFLEIDKT FARHAHLSAD ATLLTSGTTA TVALLRDGIE
210 220 230 240 250
LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC GGFVAWNSLG
260 270 280 290 300
QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI
310 320 330 340 350
NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG
360 370
KYKNSEITFS FSRSFASSGR WA
Length:372
Mass (Da):41,151
Last modified:February 7, 2006 - v1
Checksum:i5A8536B6E2F78090
GO
Isoform 2 (identifier: Q2PC20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-153: Missing.

Show »
Length:324
Mass (Da):35,755
Checksum:i452CFAA721E6D8B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365F → I in AAI18080 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023155106 – 153Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871967 mRNA. Translation: CAI44748.1.
AJ871968 mRNA. Translation: CAI44749.1.
BC118079 mRNA. Translation: AAI18080.1.
RefSeqiNP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.3. [Q2PC20-1]
UniGeneiBt.48380.

Genome annotation databases

EnsembliENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
GeneIDi540329.
KEGGibta:540329.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871967 mRNA. Translation: CAI44748.1.
AJ871968 mRNA. Translation: CAI44749.1.
BC118079 mRNA. Translation: AAI18080.1.
RefSeqiNP_001039939.1. NM_001046474.2.
XP_005207855.1. XM_005207798.3. [Q2PC20-1]
UniGeneiBt.48380.

3D structure databases

ProteinModelPortaliQ2PC20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007563.

Proteomic databases

PaxDbiQ2PC20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007563; ENSBTAP00000007563; ENSBTAG00000005754. [Q2PC20-1]
GeneIDi540329.
KEGGibta:540329.

Organism-specific databases

CTDi152926.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ2PC20.
KOiK17505.
OMAiREFRSAD.
OrthoDBiEOG091G0A0V.
TreeFamiTF354344.

Enzyme and pathway databases

ReactomeiR-BTA-70895. Branched-chain amino acid catabolism.

Gene expression databases

BgeeiENSBTAG00000005754.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1K_BOVIN
AccessioniPrimary (citable) accession number: Q2PC20
Secondary accession number(s): Q17R15, Q2PC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 7, 2006
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.