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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei316 – 3161Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciXORY342109:GIX9-1265-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:XOO1241
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000021642Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2P631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000137933.
OMAiFEVLCEF.
OrthoDBiEOG6HF61K.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2P631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDWIFGAC AVPDARMRSA ALARQEQLTK PPGALGRLEQ LAVQLAAWQR
60 70 80 90 100
TEHPAVQRVW IAVYAADHGV AAEGVSAFPQ AVTGEMVRNF ARGGAAIAVL
110 120 130 140 150
ARELGARLEV VNLGVVNDPG DLSRVRRAWI APSTANICEQ PAMTATQLRD
160 170 180 190 200
ALAAGAHSIA QAKGCDTQLF VGGEMGIGNT TAAAALGCAL LSQFPQALAG
210 220 230 240 250
AGTGLDAEGI AHKVTVITRA LALHADASTP LERLRRLGGF EIAALVGAYI
260 270 280 290 300
AAAQAGIPVL VDGFIATAAA LVASRLNPGV REWLLFGHRS QERGHAALLR
310 320 330 340
ALDAEPLLQL DLRLGEASGA AVAIPLLRSA CALHNGMATF AEAGVSDA
Length:348
Mass (Da):35,924
Last modified:February 7, 2006 - v1
Checksum:iACBD1FF408F420FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE67996.1.
RefSeqiWP_011407923.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE67996; BAE67996; BAE67996.
GeneIDi3262137.
PATRICi24111963. VBIXanOry49434_1413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE67996.1.
RefSeqiWP_011407923.1. NC_007705.1.

3D structure databases

ProteinModelPortaliQ2P631.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE67996; BAE67996; BAE67996.
GeneIDi3262137.
PATRICi24111963. VBIXanOry49434_1413.

Phylogenomic databases

HOGENOMiHOG000137933.
OMAiFEVLCEF.
OrthoDBiEOG6HF61K.

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.
BioCyciXORY342109:GIX9-1265-MONOMER.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiCOBT_XANOM
AccessioniPrimary (citable) accession number: Q2P631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: December 9, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.