Q2P3K2 (HIS8_XANOM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	XOO2120

Organism

Xanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]

Taxonomic identifier

342109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000230228
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2P3K2 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 41E22DE2CE648435	FASTA	363	38,624
	10 20 30 40 50 60 MSTSSILHLV REDLRAFAGY SSARTSALQG DVWLNANESA WGNPADPSAS TRRYPDPQPQ 70 80 90 100 110 120 GLRSALAALY GCAPEQLLIG RGSDEAIDLL VRGLCVPERD AVLVTPPVFG MYAVCARLQN 130 140 150 160 170 180 APLVDVPLVD VPDGFHADIP AIVAAALASN AKLVFLCSPS NPAGSAIALD QIEPALQALQ 190 200 210 220 230 240 GKALVVVDEA YGEFSEVPSA VGLLARYDNL AVLRTLSKAH ALAAARIGTL IANAELIAVL 250 260 270 280 290 300 RRCQAPYPVP TPCAAMAEQA LSAPALEVTR RRIAEVRSER ARVHKALVQL PGVRQVYPSQ 310 320 330 340 350 360 GNFLLVRFDD AEAAFQALLE AGVVVRDQRA VPRLSDALRI TLGTHEQNER VLSALQRTQE AAA

References

[1]

"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity." Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H. Jpn. Agric. Res. Q. 39:275-287(2005) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF 311018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008229 Genomic DNA. Translation: BAE68875.1.
RefSeq	YP_451149.1. NC_007705.1.
3D structure databases
ProteinModelPortal	Q2P3K2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2P3K2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3859254.
GenomeReviews	Gene locus XOO2120 in contig AP008229_GR.
KEGG	xom:XOO_2120.
PATRIC	24113941. VBIXanOry49434_2397.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	RDQRAVP.
PhylomeDB	Q2P3K2.
ProtClustDB	PRK04781.
Enzyme and pathway databases
BioCyc	XORY342109:XOO2120-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_XANOM

Accession

Primary (citable) accession number: Q2P3K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program