Q2P3K1 (HIS7_XANOM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidine biosynthesis bifunctional protein hisB

Including the following 2 domains:

1. Histidinol-phosphatase
   EC=3.1.3.15
2. Imidazoleglycerol-phosphate dehydratase
   Short name=IGPD
   EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	XOO2121

Organism

Xanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]

Taxonomic identifier

342109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP MF_01022 L-histidinol phosphate + H2O = L-histidinol + phosphate. HAMAP MF_01022
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP MF_01022 Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location	Cytoplasm By similarity HAMAP MF_01022.
Sequence similarities	In the N-terminal section; belongs to the histidinol-phosphatase family. In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histidinol-phosphatase activity Inferred from electronic annotation. Source: EC imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Histidine biosynthesis bifunctional protein hisB HAMAP MF_01022		PRO_1000063452
Regions
	Region	1 – 168	168	Histidinol-phosphatase HAMAP MF_01022
	Region	169 – 375	207	Imidazoleglycerol-phosphate dehydratase HAMAP MF_01022

Sequences

	Sequence		Length	Mass (Da)
	Q2P3K1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 9D784B4B6573ADE9	FASTA	375	41,887
	10 20 30 40 50 60 MTPILFVDRD GTLITEPADY QIDAYEKLRF VDHVIPAMLK LRDAGYQFVI VSNQDGLGSE 70 80 90 100 110 120 SFPRASFDGP NNLMLQIFAS QGIEFREVLI DCSWPSDNAP TRKPGVGLMV PYLQDRTIDW 130 140 150 160 170 180 ARSAMVGDRI TDIQFAQNLN IRGFQLRTDE FGGEWDWPGI AHELADAPRR AVVQRNTKET 190 200 210 220 230 240 RIRVELDLDR VAEPKTATGL PFFDHMLEQI GKHGGFALDI RAEGDLHIDE HHTIEDTGLA 250 260 270 280 290 300 LGQALREALG DKRGIGRYGF DPESSPWQVA GDTAQHGFTL PMDETIASAA LDFSGRPYFV 310 320 330 340 350 360 FDGQFKRDRL GDMPTELVPH FFRSICDASG VNLHLTVRGE NDHHKVEACF KALARALRQA 370 IRREGSALPT TKGAL

References

[1]

"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity." Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H. Jpn. Agric. Res. Q. 39:275-287(2005) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF 311018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008229 Genomic DNA. Translation: BAE68876.1.
RefSeq	YP_451150.1. NC_007705.1.
3D structure databases
ProteinModelPortal	Q2P3K1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2P3K1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3857258.
GenomeReviews	Gene locus XOO2121 in contig AP008229_GR.
KEGG	xom:XOO_2121.
PATRIC	24113943. VBIXanOry49434_2398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HBG289010.
OMA	EMVPHFF.
PhylomeDB	Q2P3K1.
ProtClustDB	PRK05446.
Enzyme and pathway databases
BioCyc	XORY342109:XOO2121-MONOMER.
Family and domain databases
HAMAP	MF_01022. Bifunc_HisB. [Tree]
InterPro	IPR023214. HAD-like_dom. IPR006549. HAD-SF_hydro_IIIA. IPR020566. His_synth_bifunc_HisB. IPR005954. HisB_N. IPR006543. Histidinol-phos. IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR013954. PNK3P. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KO	K01089.
PANTHER	PTHR23133:SF2. Imidazole-GPD. 1 hit.
Pfam	PF00475. IGPD. 1 hit. PF08645. PNK3P. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR01662. HAD-SF-IIIA. 1 hit. TIGR01261. HisB_Nterm. 1 hit. TIGR01656. Histidinol-ppas. 1 hit.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_XANOM

Accession

Primary (citable) accession number: Q2P3K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program