Reviewed, UniProtKB/Swiss-Prot Q2P3K1 (HIS7_XANOM)

Names and origin

Protein names

Recommended name:
    Histidine biosynthesis bifunctional protein hisB
Including the following 2 domains:
    1- Recommended name:
            Histidinol-phosphatase
              EC=3.1.3.15
    2- Recommended name:
            Imidazoleglycerol-phosphate dehydratase
                Short name=IGPD
              EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	XOO2121

Organism

Xanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]

Taxonomic identifier

342109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP MF_01022 L-histidinol phosphate + H2O = L-histidinol + phosphate. HAMAP MF_01022
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP MF_01022 Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	In the N-terminal section; belongs to the histidinol-phosphatase family. In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histidinol-phosphatase activity Inferred from electronic annotation. Source: HAMAP imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Histidine biosynthesis bifunctional protein hisB HAMAP MF_01022		PRO_1000063452
Regions
	Region	1 – 168	168	Histidinol-phosphatase HAMAP MF_01022
	Region	169 – 375	207	Imidazoleglycerol-phosphate dehydratase HAMAP MF_01022

Sequences

	Sequence		Length	Mass (Da)
	Q2P3K1-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 9D784B4B6573ADE9	FASTA	375	41,887
	10 20 30 40 50 60 MTPILFVDRD GTLITEPADY QIDAYEKLRF VDHVIPAMLK LRDAGYQFVI VSNQDGLGSE 70 80 90 100 110 120 SFPRASFDGP NNLMLQIFAS QGIEFREVLI DCSWPSDNAP TRKPGVGLMV PYLQDRTIDW 130 140 150 160 170 180 ARSAMVGDRI TDIQFAQNLN IRGFQLRTDE FGGEWDWPGI AHELADAPRR AVVQRNTKET 190 200 210 220 230 240 RIRVELDLDR VAEPKTATGL PFFDHMLEQI GKHGGFALDI RAEGDLHIDE HHTIEDTGLA 250 260 270 280 290 300 LGQALREALG DKRGIGRYGF DPESSPWQVA GDTAQHGFTL PMDETIASAA LDFSGRPYFV 310 320 330 340 350 360 FDGQFKRDRL GDMPTELVPH FFRSICDASG VNLHLTVRGE NDHHKVEACF KALARALRQA 370 IRREGSALPT TKGAL

References

[1]

"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity." Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H. Jpn. Agric. Res. Q. 39:275-287(2005) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008229 Genomic DNA. Translation: BAE68876.1.
RefSeq	YP_451150.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3857258.
GenomeReviews	Gene locus XOO2121 in contig AP008229_GR.
KEGG	xom:XOO_2121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2P3K1.
OMA	Q2P3K1. MVSNQDG.
Enzyme and pathway databases
BioCyc	XORY342109:XOO2121-MON.
Family and domain databases
HAMAP	MF_01022. [Tree]
InterPro	IPR006549. HAD-SF_hydro_IIIA. IPR005954. HisB_N. IPR006543. Histidinol-phos. IPR000807. Imidazole_glycer-P_deHydtase. IPR013954. PNK3P_central-region. [Graphical view]
PANTHER	PTHR23133:SF2. Imidazole-GPD. 1 hit.
Pfam	PF00475. IGPD. 1 hit. PF08645. PNK3P. 1 hit. [Graphical view]
ProDom	PD002282. IGPD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01662. HAD-SF-IIIA. 1 hit. TIGR01261. hisB_Nterm. 1 hit. TIGR01656. Histidinol-ppas. 1 hit.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_XANOM

Accession

Primary (citable) accession number: Q2P3K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)