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Q2P378

- PANC_XANOM

UniProt

Q2P378 - PANC_XANOM

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Protein

Pantothenate synthetase

Gene

panC

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donorUniRule annotation
Binding sitei62 – 621Beta-alanineUniRule annotation
Binding sitei62 – 621PantoateUniRule annotation
Binding sitei156 – 1561PantoateUniRule annotation
Binding sitei179 – 1791ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPUniRule annotation
Nucleotide bindingi150 – 1534ATPUniRule annotation
Nucleotide bindingi187 – 1904ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXORY342109:GIX9-2278-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:XOO2244
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001957: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Pantothenate synthetasePRO_0000305578Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi342109.XOO_2244.

Structurei

3D structure databases

ProteinModelPortaliQ2P378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiIVRDSDH.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2P378-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQTLTDLSA LRALVNGWKR EGLRVALVPT MGNLHVGHYS LVMLARQYAD
60 70 80 90 100
RVVSSVFVNP TQFGPNEDFA CYPRTPEADL RGLEDAGCDA LWLPDVDTMY
110 120 130 140 150
PLGTALATPI HAPGVSDVLE GECRPGHFDG VCTVVARLFN QVQPDVAAFG
160 170 180 190 200
KKDYQQLAVI RQMVADLAFP IEILGGSIVR EADGLAMSSR NQYLSAEERP
210 220 230 240 250
TSANIHKVLL QMRDSYAVGT PRAQVEDAAS HALEQAGFRV DYAVVRLPDL
260 270 280
SEPGDGHTGA HVALIAARLG STRLIDNLEF
Length:280
Mass (Da):30,380
Last modified:February 7, 2006 - v1
Checksum:iC87412C7AFADD709
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE68999.1.
RefSeqiYP_451273.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE68999; BAE68999; BAE68999.
GeneIDi3858026.
KEGGixom:XOO_2244.
PATRICi24114230. VBIXanOry49434_2539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE68999.1 .
RefSeqi YP_451273.1. NC_007705.1.

3D structure databases

ProteinModelPortali Q2P378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342109.XOO_2244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE68999 ; BAE68999 ; BAE68999 .
GeneIDi 3858026.
KEGGi xom:XOO_2244.
PATRICi 24114230. VBIXanOry49434_2539.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi IVRDSDH.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci XORY342109:GIX9-2278-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiPANC_XANOM
AccessioniPrimary (citable) accession number: Q2P378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3