ID   3HAO_XANOM              Reviewed;         176 AA.
AC   Q2P320;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   04-NOV-2008, entry version 26.
DE   RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase;
DE            EC=1.13.11.6;
DE   AltName: Full=3-hydroxyanthranilic acid dioxygenase;
DE            Short=HAD;
DE   AltName: Full=3-hydroxyanthranilate oxygenase;
DE            Short=3-HAO;
GN   OrderedLocusNames=XOO2302;
OS   Xanthomonas oryzae pv. oryzae (strain MAFF 311018).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=342109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.;
RT   "Genome sequence of Xanthomonas oryzae pv. oryzae suggests
RT   contribution of large numbers of effector genes and insertion
RT   sequences to its race diversity.";
RL   Jpn. Agric. Res. Q. 39:275-287(2005).
CC   -!- FUNCTION: Catalyzes the oxidative ring opening of 3-
CC       hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
CC       which spontaneously cyclizes to quinolinate (By similarity).
CC   -!- CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3-
CC       carboxymuconate semialdehyde.
CC   -!- COFACTOR: Binds 2 Fe(2+) ions per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the 3-HAO family.
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DR   EMBL; AP008229; BAE69057.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_451331.1; -.
DR   GeneID; 3856660; -.
DR   GenomeReviews; AP008229_GR; XOO2302.
DR   KEGG; xom:XOO_2302; -.
DR   HOGENOM; Q2P320; -.
DR   BioCyc; XORY342109:XOO2302-MON; -.
DR   GO; GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00825; -; 1.
DR   InterPro; IPR010329; 3hydroanth_dOase.
DR   Pfam; PF06052; 3-HAO; 1.
DR   TIGRFAMs; TIGR03037; anthran_nbaC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase.
FT   CHAIN         1    176       3-hydroxyanthranilate 3,4-dioxygenase.
FT                                /FTId=PRO_0000245483.
FT   METAL        48     48       Iron 1; catalytic (By similarity).
FT   METAL        54     54       Iron 1; catalytic (By similarity).
FT   METAL        92     92       Iron 1; catalytic (By similarity).
FT   METAL       121    121       Iron 2 (By similarity).
FT   METAL       124    124       Iron 2 (By similarity).
FT   METAL       158    158       Iron 2 (By similarity).
FT   METAL       161    161       Iron 2 (By similarity).
FT   BINDING      44     44       Dioxygen (By similarity).
FT   BINDING      54     54       Substrate (By similarity).
FT   BINDING      96     96       Substrate (By similarity).
FT   BINDING     106    106       Substrate (By similarity).
SQ   SEQUENCE   176 AA;  20196 MW;  4274767A24F2B088 CRC64;
     MLIPPINLHA WIEEHRHLLK PPVGNKCIQQ DGFIIMIVGG PNARTDYHYD EGPEWFFQLE
     GEMVLKVQDD GVARDIPIRA GEIFLLPPRV PHSPQRAAGS IGIVIERVRL PHEQDGLQWY
     CPQCNHKLYE AMFPLKNIET DFPPVFDHFY RSLALRTCSQ CGHLHPAPER YAAVED
//