Reviewed, UniProtKB/Swiss-Prot Q2P320 (3HAO_XANOM)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Ordered Locus Names:

XOO2302

Organism

Xanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]

Taxonomic identifier

342109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Binds 2 Fe(2+) ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: HAMAP ferrous iron binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245483
Sites
	Metal binding	48	1	Iron 1; catalytic By similarity
	Metal binding	54	1	Iron 1; catalytic By similarity
	Metal binding	92	1	Iron 1; catalytic By similarity
	Metal binding	121	1	Iron 2 By similarity
	Metal binding	124	1	Iron 2 By similarity
	Metal binding	158	1	Iron 2 By similarity
	Metal binding	161	1	Iron 2 By similarity
	Binding site	44	1	Dioxygen By similarity
	Binding site	54	1	Substrate By similarity
	Binding site	96	1	Substrate By similarity
	Binding site	106	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2P320-1 [UniParc]. Last modified July 11, 2006. Version 2. Checksum: 4274767A24F2B088	FASTA	176	20,196
	10 20 30 40 50 60 MLIPPINLHA WIEEHRHLLK PPVGNKCIQQ DGFIIMIVGG PNARTDYHYD EGPEWFFQLE 70 80 90 100 110 120 GEMVLKVQDD GVARDIPIRA GEIFLLPPRV PHSPQRAAGS IGIVIERVRL PHEQDGLQWY 130 140 150 160 170 CPQCNHKLYE AMFPLKNIET DFPPVFDHFY RSLALRTCSQ CGHLHPAPER YAAVED

References

[1]

"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity." Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H. Jpn. Agric. Res. Q. 39:275-287(2005) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008229 Genomic DNA. Translation: BAE69057.1. Different initiation.
RefSeq	YP_451331.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3856660.
GenomeReviews	Gene locus XOO2302 in contig AP008229_GR.
KEGG	xom:XOO_2302.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2P320.
Enzyme and pathway databases
BioCyc	XORY342109:XOO2302-MON.
Family and domain databases
HAMAP	MF_00825. [Tree]
InterPro	IPR010329. 3hydroanth_dOase. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_XANOM

Accession

Primary (citable) accession number: Q2P320

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	November 4, 2008
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)