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Q2P316

- KMO_XANOM

UniProt

Q2P316 - KMO_XANOM

Protein

Kynurenine 3-monooxygenase

Gene

kmo

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

    Catalytic activityi

    L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    2. kynurenine 3-monooxygenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciXORY342109:GIX9-2341-MONOMER.
    UniPathwayiUPA00253; UER00328.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
    Alternative name(s):
    Kynurenine 3-hydroxylaseUniRule annotation
    Gene namesi
    Name:kmoUniRule annotation
    Ordered Locus Names:XOO2306
    OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
    Taxonomic identifieri342109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001957: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Kynurenine 3-monooxygenasePRO_0000361951Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342109.XOO_2306.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2P316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0654.
    HOGENOMiHOG000160701.
    KOiK00486.
    OMAiQPMISVK.
    OrthoDBiEOG6716J1.

    Family and domain databases

    HAMAPiMF_01971. Kynurenine_monooxygenase.
    InterProiIPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequencei

    Sequence statusi: Complete.

    Q2P316-1 [UniParc]FASTAAdd to Basket

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    MSPVSPRSLT LIGAGLAGCL LAILLSRRGW QITVYERRGD PRIKGYECGR    50
    SINLALAERG RHALRQAGAE ELVMAKAVMM RGRMVHPLVG EPQLQRYGRD 100
    DSEVIWSIHR AALNVALLDL AEQAGARVHF YRRLHTVDFD AGYARFIDDR 150
    DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS PLGERTEFLD HSYKELEIPP 200
    LPGGGFRIEG NALHIWPRGR YMFIALPNDG GTFTVTLFLP NAGEPSFATT 250
    RNGDEAFALF ARDFPDALPL IPQLKQHWEE HPPGLLGTLT LDRWHLDGRA 300
    LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR 350
    DDAGAIQQMA LENYLEMRDR VDDPEFLLQR QLEQQLQARW PTRFVPHYTM 400
    VTFLRTRYSI ALARSEIQRE ILVEATRGHS DLSRLDWAAL ETIVHARLEP 450
    LDGAH 455
    Length:455
    Mass (Da):50,983
    Last modified:February 7, 2006 - v1
    Checksum:iCC8AE451A359FC4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69061.1.
    RefSeqiYP_451335.1. NC_007705.1.

    Genome annotation databases

    EnsemblBacteriaiBAE69061; BAE69061; BAE69061.
    GeneIDi3856664.
    KEGGixom:XOO_2306.
    PATRICi24114375. VBIXanOry49434_2610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69061.1 .
    RefSeqi YP_451335.1. NC_007705.1.

    3D structure databases

    ProteinModelPortali Q2P316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342109.XOO_2306.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE69061 ; BAE69061 ; BAE69061 .
    GeneIDi 3856664.
    KEGGi xom:XOO_2306.
    PATRICi 24114375. VBIXanOry49434_2610.

    Phylogenomic databases

    eggNOGi COG0654.
    HOGENOMi HOG000160701.
    KOi K00486.
    OMAi QPMISVK.
    OrthoDBi EOG6716J1.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00328 .
    BioCyci XORY342109:GIX9-2341-MONOMER.

    Family and domain databases

    HAMAPi MF_01971. Kynurenine_monooxygenase.
    InterProi IPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
      Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
      Jpn. Agric. Res. Q. 39:275-287(2005)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF 311018.

    Entry informationi

    Entry nameiKMO_XANOM
    AccessioniPrimary (citable) accession number: Q2P316
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3