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Q2P316 (KMO_XANOM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kynurenine 3-monooxygenase

EC=1.14.13.9
Alternative name(s):
Kynurenine 3-hydroxylase
Gene names
Name:kmo
Ordered Locus Names:XOO2306
OrganismXanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]
Taxonomic identifier342109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity. HAMAP-Rule MF_01971

Catalytic activity

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O. HAMAP-Rule MF_01971

Cofactor

FAD By similarity. HAMAP-Rule MF_01971

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. HAMAP-Rule MF_01971

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Kynurenine 3-monooxygenase HAMAP-Rule MF_01971
PRO_0000361951

Sequences

Sequence LengthMass (Da)Tools
Q2P316 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: CC8AE451A359FC4B

FASTA45550,983
        10         20         30         40         50         60 
MSPVSPRSLT LIGAGLAGCL LAILLSRRGW QITVYERRGD PRIKGYECGR SINLALAERG 

        70         80         90        100        110        120 
RHALRQAGAE ELVMAKAVMM RGRMVHPLVG EPQLQRYGRD DSEVIWSIHR AALNVALLDL 

       130        140        150        160        170        180 
AEQAGARVHF YRRLHTVDFD AGYARFIDDR DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS 

       190        200        210        220        230        240 
PLGERTEFLD HSYKELEIPP LPGGGFRIEG NALHIWPRGR YMFIALPNDG GTFTVTLFLP 

       250        260        270        280        290        300 
NAGEPSFATT RNGDEAFALF ARDFPDALPL IPQLKQHWEE HPPGLLGTLT LDRWHLDGRA 

       310        320        330        340        350        360 
LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR DDAGAIQQMA 

       370        380        390        400        410        420 
LENYLEMRDR VDDPEFLLQR QLEQQLQARW PTRFVPHYTM VTFLRTRYSI ALARSEIQRE 

       430        440        450 
ILVEATRGHS DLSRLDWAAL ETIVHARLEP LDGAH 

« Hide

References

[1]"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
Jpn. Agric. Res. Q. 39:275-287(2005)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF 311018.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008229 Genomic DNA. Translation: BAE69061.1.
RefSeqYP_451335.1. NC_007705.1.

3D structure databases

ProteinModelPortalQ2P316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342109.XOO_2306.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE69061; BAE69061; BAE69061.
GeneID3856664.
KEGGxom:XOO_2306.
PATRIC24114375. VBIXanOry49434_2610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0654.
HOGENOMHOG000160701.
KOK00486.
OMAQPMISVK.
OrthoDBEOG6716J1.
ProtClustDBCLSK903475.

Enzyme and pathway databases

BioCycXORY342109:GIX9-2341-MONOMER.
UniPathwayUPA00253; UER00328.

Family and domain databases

HAMAPMF_01971. Kynurenine_monooxygenase.
InterProIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Entry information

Entry nameKMO_XANOM
AccessionPrimary (citable) accession number: Q2P316
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways