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Protein

Kynurenine 3-monooxygenase

Gene

kmo

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. kynurenine 3-monooxygenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciXORY342109:GIX9-2341-MONOMER.
UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:kmoUniRule annotation
Ordered Locus Names:XOO2306
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001957: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Kynurenine 3-monooxygenasePRO_0000361951Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342109.XOO_2306.

Structurei

3D structure databases

ProteinModelPortaliQ2P316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0654.
HOGENOMiHOG000160701.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG6716J1.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q2P316-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPVSPRSLT LIGAGLAGCL LAILLSRRGW QITVYERRGD PRIKGYECGR
60 70 80 90 100
SINLALAERG RHALRQAGAE ELVMAKAVMM RGRMVHPLVG EPQLQRYGRD
110 120 130 140 150
DSEVIWSIHR AALNVALLDL AEQAGARVHF YRRLHTVDFD AGYARFIDDR
160 170 180 190 200
DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS PLGERTEFLD HSYKELEIPP
210 220 230 240 250
LPGGGFRIEG NALHIWPRGR YMFIALPNDG GTFTVTLFLP NAGEPSFATT
260 270 280 290 300
RNGDEAFALF ARDFPDALPL IPQLKQHWEE HPPGLLGTLT LDRWHLDGRA
310 320 330 340 350
LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR
360 370 380 390 400
DDAGAIQQMA LENYLEMRDR VDDPEFLLQR QLEQQLQARW PTRFVPHYTM
410 420 430 440 450
VTFLRTRYSI ALARSEIQRE ILVEATRGHS DLSRLDWAAL ETIVHARLEP

LDGAH
Length:455
Mass (Da):50,983
Last modified:February 7, 2006 - v1
Checksum:iCC8AE451A359FC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE69061.1.
RefSeqiWP_011408607.1. NC_007705.1.
YP_451335.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE69061; BAE69061; BAE69061.
GeneIDi3856664.
KEGGixom:XOO_2306.
PATRICi24114375. VBIXanOry49434_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE69061.1.
RefSeqiWP_011408607.1. NC_007705.1.
YP_451335.1. NC_007705.1.

3D structure databases

ProteinModelPortaliQ2P316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342109.XOO_2306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE69061; BAE69061; BAE69061.
GeneIDi3856664.
KEGGixom:XOO_2306.
PATRICi24114375. VBIXanOry49434_2610.

Phylogenomic databases

eggNOGiCOG0654.
HOGENOMiHOG000160701.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG6716J1.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.
BioCyciXORY342109:GIX9-2341-MONOMER.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiKMO_XANOM
AccessioniPrimary (citable) accession number: Q2P316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 7, 2006
Last modified: February 4, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.