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Q2P316

- KMO_XANOM

UniProt

Q2P316 - KMO_XANOM

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Protein

Kynurenine 3-monooxygenase

Gene
kmo, XOO2306
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. kynurenine 3-monooxygenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciXORY342109:GIX9-2341-MONOMER.
UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenase (EC:1.14.13.9)
Alternative name(s):
Kynurenine 3-hydroxylase
Gene namesi
Name:kmo
Ordered Locus Names:XOO2306
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001957: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Kynurenine 3-monooxygenaseUniRule annotationPRO_0000361951Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342109.XOO_2306.

Structurei

3D structure databases

ProteinModelPortaliQ2P316.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0654.
HOGENOMiHOG000160701.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG6716J1.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q2P316-1 [UniParc]FASTAAdd to Basket

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MSPVSPRSLT LIGAGLAGCL LAILLSRRGW QITVYERRGD PRIKGYECGR    50
SINLALAERG RHALRQAGAE ELVMAKAVMM RGRMVHPLVG EPQLQRYGRD 100
DSEVIWSIHR AALNVALLDL AEQAGARVHF YRRLHTVDFD AGYARFIDDR 150
DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS PLGERTEFLD HSYKELEIPP 200
LPGGGFRIEG NALHIWPRGR YMFIALPNDG GTFTVTLFLP NAGEPSFATT 250
RNGDEAFALF ARDFPDALPL IPQLKQHWEE HPPGLLGTLT LDRWHLDGRA 300
LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR 350
DDAGAIQQMA LENYLEMRDR VDDPEFLLQR QLEQQLQARW PTRFVPHYTM 400
VTFLRTRYSI ALARSEIQRE ILVEATRGHS DLSRLDWAAL ETIVHARLEP 450
LDGAH 455
Length:455
Mass (Da):50,983
Last modified:February 7, 2006 - v1
Checksum:iCC8AE451A359FC4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE69061.1.
RefSeqiYP_451335.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE69061; BAE69061; BAE69061.
GeneIDi3856664.
KEGGixom:XOO_2306.
PATRICi24114375. VBIXanOry49434_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE69061.1 .
RefSeqi YP_451335.1. NC_007705.1.

3D structure databases

ProteinModelPortali Q2P316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342109.XOO_2306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE69061 ; BAE69061 ; BAE69061 .
GeneIDi 3856664.
KEGGi xom:XOO_2306.
PATRICi 24114375. VBIXanOry49434_2610.

Phylogenomic databases

eggNOGi COG0654.
HOGENOMi HOG000160701.
KOi K00486.
OMAi QPMISVK.
OrthoDBi EOG6716J1.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00328 .
BioCyci XORY342109:GIX9-2341-MONOMER.

Family and domain databases

HAMAPi MF_01971. Kynurenine_monooxygenase.
InterProi IPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiKMO_XANOM
AccessioniPrimary (citable) accession number: Q2P316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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