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Q2P310

- NADK_XANOM

UniProt

Q2P310 - NADK_XANOM

Protein

NAD kinase

Gene

nadK

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei147 – 1471NADUniRule annotation
    Binding sitei155 – 1551NAD; via carbonyl oxygenUniRule annotation
    Binding sitei182 – 1821NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi117 – 1182NADUniRule annotation
    Nucleotide bindingi158 – 1636NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciXORY342109:GIX9-2347-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:XOO2312
    OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
    Taxonomic identifieri342109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001957: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258NAD kinasePRO_0000229714Add
    BLAST

    Proteomic databases

    PRIDEiQ2P310.

    Interactioni

    Protein-protein interaction databases

    STRINGi342109.XOO_2312.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2P310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiHESTVSI.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2P310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAPPRIAFL ASPAEPAVAA RARLVQRFGD HALDCADIVC ALGGDGFMLQ    50
    TLHRHGASNK PVFGMKLGSV GFLMNQYRDD EDDLLERLQR AEPAYLRPLE 100
    MQVQTESGAS AGSLAYNEVS LLRQTRQAAH LSIDLNGQTR IAELIGDGVM 150
    VATPAGSTAY NYSAHGPILP LGSHTLALTP IAPYRPRRWR GAILKADTAV 200
    RFRVLDPYKR PVSVTADSHE IRDVVEVTIR ESTQRQVTLL FDPEHNLEER 250
    IFSEQFAV 258
    Length:258
    Mass (Da):28,398
    Last modified:February 7, 2006 - v1
    Checksum:iE5F36A38278FA7B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69067.1.
    RefSeqiWP_011408609.1. NC_007705.1.
    YP_451341.1. NC_007705.1.

    Genome annotation databases

    EnsemblBacteriaiBAE69067; BAE69067; BAE69067.
    GeneIDi3856670.
    KEGGixom:XOO_2312.
    PATRICi24114389. VBIXanOry49434_2617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69067.1 .
    RefSeqi WP_011408609.1. NC_007705.1.
    YP_451341.1. NC_007705.1.

    3D structure databases

    ProteinModelPortali Q2P310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342109.XOO_2312.

    Proteomic databases

    PRIDEi Q2P310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE69067 ; BAE69067 ; BAE69067 .
    GeneIDi 3856670.
    KEGGi xom:XOO_2312.
    PATRICi 24114389. VBIXanOry49434_2617.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi HESTVSI.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci XORY342109:GIX9-2347-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
      Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
      Jpn. Agric. Res. Q. 39:275-287(2005)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF 311018.

    Entry informationi

    Entry nameiNADK_XANOM
    AccessioniPrimary (citable) accession number: Q2P310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3