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Q2P310

- NADK_XANOM

UniProt

Q2P310 - NADK_XANOM

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Protein
NAD kinase
Gene
nadK, XOO2312
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor By similarity
Binding sitei147 – 1471NAD By similarity
Binding sitei155 – 1551NAD; via carbonyl oxygen By similarity
Binding sitei182 – 1821NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NAD By similarity
Nucleotide bindingi117 – 1182NAD By similarity
Nucleotide bindingi158 – 1636NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciXORY342109:GIX9-2347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:XOO2312
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001957: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258NAD kinaseUniRule annotation
PRO_0000229714Add
BLAST

Proteomic databases

PRIDEiQ2P310.

Interactioni

Protein-protein interaction databases

STRINGi342109.XOO_2312.

Structurei

3D structure databases

ProteinModelPortaliQ2P310.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2P310-1 [UniParc]FASTAAdd to Basket

« Hide

MTAPPRIAFL ASPAEPAVAA RARLVQRFGD HALDCADIVC ALGGDGFMLQ    50
TLHRHGASNK PVFGMKLGSV GFLMNQYRDD EDDLLERLQR AEPAYLRPLE 100
MQVQTESGAS AGSLAYNEVS LLRQTRQAAH LSIDLNGQTR IAELIGDGVM 150
VATPAGSTAY NYSAHGPILP LGSHTLALTP IAPYRPRRWR GAILKADTAV 200
RFRVLDPYKR PVSVTADSHE IRDVVEVTIR ESTQRQVTLL FDPEHNLEER 250
IFSEQFAV 258
Length:258
Mass (Da):28,398
Last modified:February 7, 2006 - v1
Checksum:iE5F36A38278FA7B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE69067.1.
RefSeqiWP_011408609.1. NC_007705.1.
YP_451341.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE69067; BAE69067; BAE69067.
GeneIDi3856670.
KEGGixom:XOO_2312.
PATRICi24114389. VBIXanOry49434_2617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008229 Genomic DNA. Translation: BAE69067.1 .
RefSeqi WP_011408609.1. NC_007705.1.
YP_451341.1. NC_007705.1.

3D structure databases

ProteinModelPortali Q2P310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342109.XOO_2312.

Proteomic databases

PRIDEi Q2P310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE69067 ; BAE69067 ; BAE69067 .
GeneIDi 3856670.
KEGGi xom:XOO_2312.
PATRICi 24114389. VBIXanOry49434_2617.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci XORY342109:GIX9-2347-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiNADK_XANOM
AccessioniPrimary (citable) accession number: Q2P310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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