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Q2P0G4 (Q2P0G4_XANOM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Siroheme synthase EMBL BAE69963.1
Gene names
Ordered Locus Names:XOO3208
OrganismXanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]
Taxonomic identifier342109 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas ›

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme By similarity. SAAS SAAS012409

Catalytic activity

Precorrin-2 + NAD+ = sirohydrochlorin + NADH. SAAS SAAS012409

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2. SAAS SAAS014776

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1. SAAS SAAS014776

Siroheme + 2 H+ = sirohydrochlorin + Fe2+. SAAS SAAS012409

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. SAAS SAAS012409

Cofactor biosynthesis; adenosylcobalamin biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. SAAS SAAS012409

Porphyrin metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. SAAS SAAS012409

Porphyrin metabolism; siroheme biosynthesis; siroheme from sirohydrochlorin: step 1/1. SAAS SAAS012409

Porphyrin metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. SAAS SAAS012409

Sequence similarities

Belongs to the precorrin methyltransferase family. RuleBase RU003960

Sequences

Sequence LengthMass (Da)Tools
Q2P0G4 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: E7CA82B15002C594

FASTA40142,197
        10         20         30         40         50         60 
MASAFPLLTD LRGRAVLVVG GGADAERATA QLLQAGALPL VGAPELTAQL RRWAQSRQLR 

        70         80         90        100        110        120 
WLEGRFDTAW LALPDQPVWL AIAASESATL NDAIRHAANA RRLLTHDAAP AASATAPVRP 

       130        140        150        160        170        180 
PAPRSAIGTL APGSVSLVGA GPGDPGLLTR HALRALRQAE VVLHDRLVSP QILRLARPGA 

       190        200        210        220        230        240 
RLIAVGKSAQ GHSTRQEQIH ALMLEHARAG HRVVRLKGGD SFVFGRGGEE LEFLRAHGIG 

       250        260        270        280        290        300 
FQVIPGITAA VACAAYAGIP LTHRDHAQSL RLITAHCKDS LDTLDWHALG QERQTLAFYM 

       310        320        330        340        350        360 
GVAGLDAIQQ RLLQAGRAAS TPFALVENGS RPQQRVITGT LASLATIARQ HAVAAPALLI 

       370        380        390        400 
LGEVAALAQT LHWFGNAPLS APLLPHSPLA TPDTPTLAHA A

« Hide

References

[1]"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
Jpn. Agric. Res. Q. 39:275-287(2005)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF 311018.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008229 Genomic DNA. Translation: BAE69963.1.
RefSeqYP_452237.1. NC_007705.1.

3D structure databases

ProteinModelPortalQ2P0G4.
ModBaseSearch...

Protein-protein interaction databases

STRING342109.XOO_3208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE69963; BAE69963; BAE69963.
GeneID3856496.
KEGGxom:XOO_3208.
PATRIC24116515. VBIXanOry49434_3661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0007.
HOGENOMHOG000013584.
KOK02302.
OMAATGHSEG.
ProtClustDBCLSK451715.

Enzyme and pathway databases

UniPathwayUPA00148; UER00211.
UPA00148; UER00222.
UPA00262; UER00211.
UPA00262; UER00222.
UPA00262; UER00376.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR012409. Sirohaem_synth.
IPR006367. Sirohaem_synthase_N.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
PIRSFPIRSF036426. Sirohaem_synth. 1 hit.
SUPFAMSSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
TIGR01470. cysG_Nterm. 1 hit.
PROSITEPS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2P0G4_XANOM
AccessionPrimary (citable) accession number: Q2P0G4
Entry history
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info