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Q2P0G4

- Q2P0G4_XANOM

UniProt

Q2P0G4 - Q2P0G4_XANOM

Protein
Submitted name:

Siroheme synthase

Gene

XOO3208

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.SAAS annotation

    Catalytic activityi

    Precorrin-2 + NAD+ = sirohydrochlorin + NADH.SAAS annotation
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.SAAS annotation
    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.SAAS annotation
    Siroheme + 2 H+ = sirohydrochlorin + Fe2+.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. precorrin-2 dehydrogenase activity Source: InterPro
    3. sirohydrochlorin ferrochelatase activity Source: InterPro
    4. uroporphyrin-III C-methyltransferase activity Source: InterPro

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. siroheme biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseSAAS annotation, MethyltransferaseUniRule annotationSAAS annotation, OxidoreductaseSAAS annotation, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesisSAAS annotation, Porphyrin biosynthesisSAAS annotation

    Keywords - Ligandi

    NADSAAS annotation, S-adenosyl-L-methionineSAAS annotation

    Enzyme and pathway databases

    BioCyciXORY342109:GIX9-3260-MONOMER.
    UniPathwayiUPA00148; UER00211.
    UPA00148; UER00222.
    UPA00262; UER00211.
    UPA00262; UER00222.
    UPA00262; UER00376.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Siroheme synthaseImported
    Gene namesi
    Ordered Locus Names:XOO3208Imported
    OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)Imported
    Taxonomic identifieri342109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001957: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi342109.XOO_3208.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2P0G4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000013584.
    KOiK02302.
    OMAiQQRFIGQ.
    OrthoDBiEOG6DRPFR.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR012409. Sirohaem_synth.
    IPR006367. Sirohaem_synthase_N.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036426. Sirohaem_synth. 1 hit.
    SUPFAMiSSF53790. SSF53790. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    TIGR01470. cysG_Nterm. 1 hit.
    PROSITEiPS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2P0G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAFPLLTD LRGRAVLVVG GGADAERATA QLLQAGALPL VGAPELTAQL    50
    RRWAQSRQLR WLEGRFDTAW LALPDQPVWL AIAASESATL NDAIRHAANA 100
    RRLLTHDAAP AASATAPVRP PAPRSAIGTL APGSVSLVGA GPGDPGLLTR 150
    HALRALRQAE VVLHDRLVSP QILRLARPGA RLIAVGKSAQ GHSTRQEQIH 200
    ALMLEHARAG HRVVRLKGGD SFVFGRGGEE LEFLRAHGIG FQVIPGITAA 250
    VACAAYAGIP LTHRDHAQSL RLITAHCKDS LDTLDWHALG QERQTLAFYM 300
    GVAGLDAIQQ RLLQAGRAAS TPFALVENGS RPQQRVITGT LASLATIARQ 350
    HAVAAPALLI LGEVAALAQT LHWFGNAPLS APLLPHSPLA TPDTPTLAHA 400
    A 401
    Length:401
    Mass (Da):42,197
    Last modified:February 7, 2006 - v1
    Checksum:iE7CA82B15002C594
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69963.1.
    RefSeqiWP_011259880.1. NC_007705.1.
    YP_452237.1. NC_007705.1.

    Genome annotation databases

    EnsemblBacteriaiBAE69963; BAE69963; BAE69963.
    GeneIDi3856496.
    KEGGixom:XOO_3208.
    PATRICi24116515. VBIXanOry49434_3661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE69963.1 .
    RefSeqi WP_011259880.1. NC_007705.1.
    YP_452237.1. NC_007705.1.

    3D structure databases

    ProteinModelPortali Q2P0G4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342109.XOO_3208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE69963 ; BAE69963 ; BAE69963 .
    GeneIDi 3856496.
    KEGGi xom:XOO_3208.
    PATRICi 24116515. VBIXanOry49434_3661.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000013584.
    KOi K02302.
    OMAi QQRFIGQ.
    OrthoDBi EOG6DRPFR.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00211 .
    UPA00148 ; UER00222 .
    UPA00262 ; UER00211 .
    UPA00262 ; UER00222 .
    UPA00262 ; UER00376 .
    BioCyci XORY342109:GIX9-3260-MONOMER.

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR012409. Sirohaem_synth.
    IPR006367. Sirohaem_synthase_N.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036426. Sirohaem_synth. 1 hit.
    SUPFAMi SSF53790. SSF53790. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    TIGR01470. cysG_Nterm. 1 hit.
    PROSITEi PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
      Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
      Jpn. Agric. Res. Q. 39:275-287(2005)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF 311018Imported.

    Entry informationi

    Entry nameiQ2P0G4_XANOM
    AccessioniPrimary (citable) accession number: Q2P0G4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported, Multifunctional enzymeSAAS annotation

    External Data

    Dasty 3