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Protein
Submitted name:

Siroheme synthase

Gene

XOO3208

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.SAAS annotation

Catalytic activityi

Precorrin-2 + NAD+ = sirohydrochlorin + NADH.SAAS annotation
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.SAAS annotation
S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.SAAS annotation
Siroheme + 2 H+ = sirohydrochlorin + Fe2+.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW
  2. methyltransferase activity Source: UniProtKB-KW
  3. precorrin-2 dehydrogenase activity Source: InterPro

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. siroheme biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseSAAS annotation, MethyltransferaseUniRule annotationSAAS annotation, OxidoreductaseSAAS annotation, Transferase

Keywords - Biological processi

Cobalamin biosynthesisSAAS annotation, Porphyrin biosynthesisSAAS annotation

Keywords - Ligandi

NADSAAS annotation, S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

BioCyciXORY342109:GIX9-3260-MONOMER.
UniPathwayiUPA00148; UER00211.
UPA00148; UER00222.
UPA00262; UER00211.
UPA00262; UER00222.
UPA00262; UER00376.

Names & Taxonomyi

Protein namesi
Submitted name:
Siroheme synthaseImported
Gene namesi
Ordered Locus Names:XOO3208Imported
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)Imported
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001957 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi342109.XOO_3208.

Structurei

3D structure databases

ProteinModelPortaliQ2P0G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000013584.
KOiK02302.
OMAiLSETLNW.
OrthoDBiEOG6DRPFR.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
TIGR01470. cysG_Nterm. 1 hit.
PROSITEiPS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2P0G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAFPLLTD LRGRAVLVVG GGADAERATA QLLQAGALPL VGAPELTAQL
60 70 80 90 100
RRWAQSRQLR WLEGRFDTAW LALPDQPVWL AIAASESATL NDAIRHAANA
110 120 130 140 150
RRLLTHDAAP AASATAPVRP PAPRSAIGTL APGSVSLVGA GPGDPGLLTR
160 170 180 190 200
HALRALRQAE VVLHDRLVSP QILRLARPGA RLIAVGKSAQ GHSTRQEQIH
210 220 230 240 250
ALMLEHARAG HRVVRLKGGD SFVFGRGGEE LEFLRAHGIG FQVIPGITAA
260 270 280 290 300
VACAAYAGIP LTHRDHAQSL RLITAHCKDS LDTLDWHALG QERQTLAFYM
310 320 330 340 350
GVAGLDAIQQ RLLQAGRAAS TPFALVENGS RPQQRVITGT LASLATIARQ
360 370 380 390 400
HAVAAPALLI LGEVAALAQT LHWFGNAPLS APLLPHSPLA TPDTPTLAHA

A
Length:401
Mass (Da):42,197
Last modified:February 7, 2006 - v1
Checksum:iE7CA82B15002C594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE69963.1.
RefSeqiYP_452237.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE69963; BAE69963; BAE69963.
KEGGixom:XOO_3208.
PATRICi24116515. VBIXanOry49434_3661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE69963.1.
RefSeqiYP_452237.1. NC_007705.1.

3D structure databases

ProteinModelPortaliQ2P0G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342109.XOO_3208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE69963; BAE69963; BAE69963.
KEGGixom:XOO_3208.
PATRICi24116515. VBIXanOry49434_3661.

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000013584.
KOiK02302.
OMAiLSETLNW.
OrthoDBiEOG6DRPFR.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.
UPA00148; UER00222.
UPA00262; UER00211.
UPA00262; UER00222.
UPA00262; UER00376.
BioCyciXORY342109:GIX9-3260-MONOMER.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
TIGR01470. cysG_Nterm. 1 hit.
PROSITEiPS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018Imported.

Entry informationi

Entry nameiQ2P0G4_XANOM
AccessioniPrimary (citable) accession number: Q2P0G4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, Multifunctional enzymeSAAS annotation

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.