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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciXORY342109:GIX9-3403-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:XOO3351
OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
Taxonomic identifieri342109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Glycine dehydrogenase (decarboxylating)PRO_1000045628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2P021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000002547.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2P021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTPSSLCD LEHHSAFVER HIGPNDAEIA QMLEVVGHAS LDALTDAIVP
60 70 80 90 100
GNIKSPAPLA LPEAITEEEA LVKIRAIADK NTVYRNFIGQ GYYGTHTPKV
110 120 130 140 150
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMQIANASL
160 170 180 190 200
LDEATAAAEA MTLAKRSAKS RSDIFFVHDA VHPQTLELLR TRAEPLDIML
210 220 230 240 250
RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ GGLVAVATDL
260 270 280 290 300
LALTLIAAPG QWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG
310 320 330 340 350
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA
360 370 380 390 400
VYHGPDGLTR IARRTHRLAA ILAAALRGAG VTVGEHFFDT LHVKAIDADA
410 420 430 440 450
IHARARAAGI NLRAIDSEAV GISLDETTTR ADVVALAQLF GAMADVDALD
460 470 480 490 500
AATADALPQG LLRSSAFLTH PVFNTHHSEH ELLRYMRSLA DKDLAMDRTM
510 520 530 540 550
IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA QLIDELEAML
560 570 580 590 600
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEAHRD ICLIPESAHG
610 620 630 640 650
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST
660 670 680 690 700
HGVFEEDVVA ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPCAV KSHLAPFLPR AGLHAGEGQT AAIHGGGFNS
760 770 780 790 800
GSGSGHSSRI GGMVSAAAYG SASILPISWM YVTMMGSAGL RKATQVALLN
810 820 830 840 850
ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI GAEDIAKRLI
860 870 880 890 900
DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG
910 920 930 940 950
RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA
960 970 980
RVDNVYGDKN VMCACIPVDA YKIPVDAYKE DAEA
Length:984
Mass (Da):105,426
Last modified:February 7, 2006 - v1
Checksum:iA6D61E47C931048F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE70106.1.
RefSeqiWP_011409248.1. NC_007705.1.
YP_452380.1. NC_007705.1.

Genome annotation databases

EnsemblBacteriaiBAE70106; BAE70106; BAE70106.
KEGGixom:XOO_3351.
PATRICi24116839. VBIXanOry49434_3823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008229 Genomic DNA. Translation: BAE70106.1.
RefSeqiWP_011409248.1. NC_007705.1.
YP_452380.1. NC_007705.1.

3D structure databases

ProteinModelPortaliQ2P021.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE70106; BAE70106; BAE70106.
KEGGixom:XOO_3351.
PATRICi24116839. VBIXanOry49434_3823.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000002547.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciXORY342109:GIX9-3403-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
    Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
    Jpn. Agric. Res. Q. 39:275-287(2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF 311018.

Entry informationi

Entry nameiGCSP_XANOM
AccessioniPrimary (citable) accession number: Q2P021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.