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Q2P021

- GCSP_XANOM

UniProt

Q2P021 - GCSP_XANOM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciXORY342109:GIX9-3403-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:XOO3351
    OrganismiXanthomonas oryzae pv. oryzae (strain MAFF 311018)
    Taxonomic identifieri342109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001957: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 984984Glycine dehydrogenase (decarboxylating)PRO_1000045628Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi342109.XOO_3351.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2P021.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000002547.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2P021-1 [UniParc]FASTAAdd to Basket

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    MSQTPSSLCD LEHHSAFVER HIGPNDAEIA QMLEVVGHAS LDALTDAIVP    50
    GNIKSPAPLA LPEAITEEEA LVKIRAIADK NTVYRNFIGQ GYYGTHTPKV 100
    ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMQIANASL 150
    LDEATAAAEA MTLAKRSAKS RSDIFFVHDA VHPQTLELLR TRAEPLDIML 200
    RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ GGLVAVATDL 250
    LALTLIAAPG QWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
    RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
    VYHGPDGLTR IARRTHRLAA ILAAALRGAG VTVGEHFFDT LHVKAIDADA 400
    IHARARAAGI NLRAIDSEAV GISLDETTTR ADVVALAQLF GAMADVDALD 450
    AATADALPQG LLRSSAFLTH PVFNTHHSEH ELLRYMRSLA DKDLAMDRTM 500
    IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA QLIDELEAML 550
    VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEAHRD ICLIPESAHG 600
    TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST 650
    HGVFEEDVVA ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
    HKTFCIPHGG GGPGVGPCAV KSHLAPFLPR AGLHAGEGQT AAIHGGGFNS 750
    GSGSGHSSRI GGMVSAAAYG SASILPISWM YVTMMGSAGL RKATQVALLN 800
    ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI GAEDIAKRLI 850
    DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG 900
    RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA 950
    RVDNVYGDKN VMCACIPVDA YKIPVDAYKE DAEA 984
    Length:984
    Mass (Da):105,426
    Last modified:February 7, 2006 - v1
    Checksum:iA6D61E47C931048F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE70106.1.
    RefSeqiYP_452380.1. NC_007705.1.

    Genome annotation databases

    EnsemblBacteriaiBAE70106; BAE70106; BAE70106.
    GeneIDi3859885.
    KEGGixom:XOO_3351.
    PATRICi24116839. VBIXanOry49434_3823.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008229 Genomic DNA. Translation: BAE70106.1 .
    RefSeqi YP_452380.1. NC_007705.1.

    3D structure databases

    ProteinModelPortali Q2P021.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342109.XOO_3351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE70106 ; BAE70106 ; BAE70106 .
    GeneIDi 3859885.
    KEGGi xom:XOO_3351.
    PATRICi 24116839. VBIXanOry49434_3823.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000002547.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci XORY342109:GIX9-3403-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
      Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
      Jpn. Agric. Res. Q. 39:275-287(2005)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF 311018.

    Entry informationi

    Entry nameiGCSP_XANOM
    AccessioniPrimary (citable) accession number: Q2P021
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3