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Q2P021 (GCSP_XANOM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:XOO3351
OrganismXanthomonas oryzae pv. oryzae (strain MAFF 311018) [Complete proteome] [HAMAP]
Taxonomic identifier342109 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 984984Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045628

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2P021 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: A6D61E47C931048F

FASTA984105,426
        10         20         30         40         50         60 
MSQTPSSLCD LEHHSAFVER HIGPNDAEIA QMLEVVGHAS LDALTDAIVP GNIKSPAPLA 

        70         80         90        100        110        120 
LPEAITEEEA LVKIRAIADK NTVYRNFIGQ GYYGTHTPKV ILRNILENPA WYTAYTPYQA 

       130        140        150        160        170        180 
EISQGRMEAL INFQTLCADL TGMQIANASL LDEATAAAEA MTLAKRSAKS RSDIFFVHDA 

       190        200        210        220        230        240 
VHPQTLELLR TRAEPLDIML RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ 

       250        260        270        280        290        300 
GGLVAVATDL LALTLIAAPG QWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 

       310        320        330        340        350        360 
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPDGLTR 

       370        380        390        400        410        420 
IARRTHRLAA ILAAALRGAG VTVGEHFFDT LHVKAIDADA IHARARAAGI NLRAIDSEAV 

       430        440        450        460        470        480 
GISLDETTTR ADVVALAQLF GAMADVDALD AATADALPQG LLRSSAFLTH PVFNTHHSEH 

       490        500        510        520        530        540 
ELLRYMRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA 

       550        560        570        580        590        600 
QLIDELEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEAHRD ICLIPESAHG 

       610        620        630        640        650        660 
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST HGVFEEDVVA 

       670        680        690        700        710        720 
ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 

       730        740        750        760        770        780 
KSHLAPFLPR AGLHAGEGQT AAIHGGGFNS GSGSGHSSRI GGMVSAAAYG SASILPISWM 

       790        800        810        820        830        840 
YVTMMGSAGL RKATQVALLN ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI 

       850        860        870        880        890        900 
GAEDIAKRLI DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG 

       910        920        930        940        950        960 
RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA RVDNVYGDKN 

       970        980 
VMCACIPVDA YKIPVDAYKE DAEA 

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References

[1]"Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."
Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.
Jpn. Agric. Res. Q. 39:275-287(2005)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF 311018.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008229 Genomic DNA. Translation: BAE70106.1.
RefSeqYP_452380.1. NC_007705.1.

3D structure databases

ProteinModelPortalQ2P021.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342109.XOO_3351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE70106; BAE70106; BAE70106.
GeneID3859885.
KEGGxom:XOO_3351.
PATRIC24116839. VBIXanOry49434_3823.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000002547.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycXORY342109:GIX9-3403-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_XANOM
AccessionPrimary (citable) accession number: Q2P021
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families