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Q2NX35 (MTLD_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:SG0015
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011811

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NX35 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 4226CEC89748BA18

FASTA38241,274
        10         20         30         40         50         60 
MKVLHFGAGN IGRGFIGKLL ADAGVEVVFA DVNQQVLDAL NQRHQYQVRV VGEQAQVETV 

        70         80         90        100        110        120 
RGVSAVHSGS DDVVALIASV DLVTAAVGPQ ILERIAPAIA RGLVKRHDGG GTQPLNIIAC 

       130        140        150        160        170        180 
ENMVRGTSQL KQHVLNALEP RYHAWVDQHV GFVDSAVDRI VPPVEAGSDD PLAVTVESFS 

       190        200        210        220        230        240 
EWILDKTQFK GVPPALGGME LTDNLMAFME RKLFTLNTGH AITAYLGQLA GHQTIRDAIL 

       250        260        270        280        290        300 
DPAVRQTVKG AMEESGAVLI NRYGFDARKH AAYINKILQR FENPYLHDDV ERVGRQPLRK 

       310        320        330        340        350        360 
LGAGDRLIKP LRGTLEYGLG DANLVTGIAA AMHYHSDQDP QAKEWAALLA EVGPQAALAK 

       370        380 
VSGLEEDSEV VAQVVNAYNA MQ

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References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008232 Genomic DNA. Translation: BAE73290.1.
RefSeqYP_453695.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NX35.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2NX35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3867672.
GenomeReviewsGene locus SG0015 in contig AP008232_GR.
KEGGsgl:SG0015.
NMPDRfig|343509.6.peg.42.
PATRIC23645397. VBISodGlo61428_0045.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBQ2NX35.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycSGLO343509:SG0015-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_SODGM
AccessionPrimary (citable) accession number: Q2NX35
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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