Reviewed, UniProtKB/Swiss-Prot Q2NX35 (MTLD_SODGM)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SG0015

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000011811
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NX35-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 4226CEC89748BA18	FASTA	382	41,274
	10 20 30 40 50 60 MKVLHFGAGN IGRGFIGKLL ADAGVEVVFA DVNQQVLDAL NQRHQYQVRV VGEQAQVETV 70 80 90 100 110 120 RGVSAVHSGS DDVVALIASV DLVTAAVGPQ ILERIAPAIA RGLVKRHDGG GTQPLNIIAC 130 140 150 160 170 180 ENMVRGTSQL KQHVLNALEP RYHAWVDQHV GFVDSAVDRI VPPVEAGSDD PLAVTVESFS 190 200 210 220 230 240 EWILDKTQFK GVPPALGGME LTDNLMAFME RKLFTLNTGH AITAYLGQLA GHQTIRDAIL 250 260 270 280 290 300 DPAVRQTVKG AMEESGAVLI NRYGFDARKH AAYINKILQR FENPYLHDDV ERVGRQPLRK 310 320 330 340 350 360 LGAGDRLIKP LRGTLEYGLG DANLVTGIAA AMHYHSDQDP QAKEWAALLA EVGPQAALAK 370 380 VSGLEEDSEV VAQVVNAYNA MQ

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE73290.1.
RefSeq	YP_453695.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3867672.
GenomeReviews	Gene locus SG0015 in contig AP008232_GR.
KEGG	sgl:SG0015.
NMPDR	fig|343509.6.peg.42.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NX35.
Enzyme and pathway databases
BioCyc	SGLO343509:SG0015-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_SODGM

Accession

Primary (citable) accession number: Q2NX35

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)