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Q2NWQ7

- PUR9_SODGM

UniProt

Q2NWQ7 - PUR9_SODGM

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, SG0143
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-153-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SG0143
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018960Add
BLAST

Proteomic databases

PRIDEiQ2NWQ7.

Interactioni

Protein-protein interaction databases

STRINGi343509.SG0143.

Structurei

3D structure databases

ProteinModelPortaliQ2NWQ7.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NWQ7-1 [UniParc]FASTAAdd to Basket

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MQPPRPVRRA LLSVSDKTGI LAFARSLSER GVELLSTGGT ARLLAEAGLP    50
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRDIDDAIM REHDIAPIDM 100
VVVNLYPFAA TVARAECTRE EAVENIDIGG PTMVRSAAKN HKDVAIVVNS 150
ANYPAVVAEM DQHSGSLTLE TRFDLAIKAF EHTAAYDSMI ANYFGSQVPA 200
YHGDAKQPSG RFPRTLNLNF IKKQDMRYGE NSHQMAAFYT DPETPEASVA 250
TAQQLQGKAL SYNNIADTDA ALECVKTFTE AACVIVKHAN PCGVATSDTL 300
LAAYNRAYQT DPTSAFGGII AFNRPLDADT AKAIVSRQFV EVIIAPAVDD 350
DALGVLAGKQ NVRVLACGNL QQPSPGLDFK RVNGGLLVQE RDVGMVDLQD 400
LSVVTERQPT EEEMRDALFC WKVAKFVKSN AIVYARYQRT IGIGAGQMSR 450
VYSAKIAGIK AADEGLDVKG SAMASDAFFP FRDGIDAAAA VGVRCVIQPG 500
GSIHDNEIIA AANEHGIAMI FTHMRHFRH 529
Length:529
Mass (Da):57,156
Last modified:February 7, 2006 - v1
Checksum:i39066B5137AEB29A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE73418.1.
RefSeqiWP_011410007.1. NC_007712.1.
YP_453823.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE73418; BAE73418; SG0143.
GeneIDi3868509.
KEGGisgl:SG0143.
PATRICi23645946. VBISodGlo61428_0311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE73418.1 .
RefSeqi WP_011410007.1. NC_007712.1.
YP_453823.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NWQ7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 343509.SG0143.

Proteomic databases

PRIDEi Q2NWQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE73418 ; BAE73418 ; SG0143 .
GeneIDi 3868509.
KEGGi sgl:SG0143.
PATRICi 23645946. VBISodGlo61428_0311.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SGLO343509:GJJC-153-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiPUR9_SODGM
AccessioniPrimary (citable) accession number: Q2NWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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