Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2NW99 (DSBD_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbD
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase
Short name=Disulfide reductase
Gene names
Name:dsbD
Ordered Locus Names:SG0301
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 590566Thiol:disulfide interchange protein DsbD HAMAP MF_00399
PRO_0000304400

Regions

Transmembrane193 – 21321Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane349 – 36921Helical; Potential
Transmembrane388 – 40821Helical; Potential
Transmembrane409 – 42921Helical; Potential
Transmembrane438 – 45821Helical; Potential
Domain457 – 590134Thioredoxin

Amino acid modifications

Disulfide bond128 ↔ 134Redox-active By similarity
Disulfide bond205 ↔ 327Redox-active By similarity
Disulfide bond505 ↔ 508Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NW99 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 6D2389126F0E9D2A

FASTA59064,142
        10         20         30         40         50         60 
MAQRRFTLIL LACLTCLPLL PAHAALFGNS HGNQFIPAEQ AFRFDFRQQG SQLTLSWDIH 

        70         80         90        100        110        120 
PGYYLYRQQI RLEPVNATLG AFTLPAGSRH HDEFYGDDVA IYRDELNITL PLAQAQNDSQ 

       130        140        150        160        170        180 
LRVTWQGCAE AGFCYPPETQ VIPLSAIAAA PPSGTGIGST ALIPAPPPAG GQGIITPAPP 

       190        200        210        220        230        240 
PQSNNLPFSP LWALLIGIGI AFTPCVLPMY PLISAVILGN RLQLSTARVL LLAVVYVMGM 

       250        260        270        280        290        300 
AITYTLLGVA VAAAGLQFQA VLQQPALLIG LAALFILLAL SMFGVFTLQL PSALQTHLAL 

       310        320        330        340        350        360 
WSNRQRQGTL PGVFIMGALA GLFCSPCTTA PLSAILLYIA QSGNLWFSGF TLWLYAVGMG 

       370        380        390        400        410        420 
IPLILVALFG HRLLPKRGPW MQQVKQGFGF VILALPVFLL ERVLGDSWGT RLWSLLGVAF 

       430        440        450        460        470        480 
FGWGFLLCLQ ARWRGARWLA VLMLGLTLIS ARPLQDWLWG APADMTSTTG AAPVFQPVQT 

       490        500        510        520        530        540 
LAQITQALNA APGKPVMLDL YADWCVACKE FDKYTFRDPA VVEQMSRFTL LQADVTANAP 

       550        560        570        580        590 
VQRMLLGQLQ VIGLPTILFF DSRGHEIPGS RLTGYMNAAD FTRHLRKLAP

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008232 Genomic DNA. Translation: BAE73576.1.
RefSeqYP_453981.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NW99.
SMRQ2NW99. Positions 34-149, 470-590.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2NW99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3868569.
GenomeReviewsGene locus SG0301 in contig AP008232_GR.
KEGGsgl:SG0301.
NMPDRfig|343509.6.peg.709.
PATRIC23646935. VBISodGlo61428_0797.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4232.
HOGENOMHBG640883.
OMAKPHTDEY.
PhylomeDBQ2NW99.
ProtClustDBPRK00293.

Enzyme and pathway databases

BioCycSGLO343509:SG0301-MONOMER.

Family and domain databases

HAMAPMF_00399. DbsD.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM_dom.
IPR022910. Thiol_diS_interchange_DbsD.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
KOK04084.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBD_SODGM
AccessionPrimary (citable) accession number: Q2NW99
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents