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Q2NW05 (TYPH_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:SG0395
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000069678

Sequences

Sequence LengthMass (Da)Tools
Q2NW05 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 75969D1A31F74E44

FASTA44346,913
        10         20         30         40         50         60 
MFLAQEIIRK KRDGEPLSDE EIRFFINGVY DNTVSEGQIA ALAMTIFFHD MDLQERVALT 

        70         80         90        100        110        120 
LAMRDSGHTL DWRREALGGP VVDKHSTGGV GDVTSLMLGP MIAACGGFVP MVSGRGLGHT 

       130        140        150        160        170        180 
GGTLDKLEAI PGLAIFLDDD AFRSQVKQVG VAIMGQTHSL APADKRIYAT RDITATVDSI 

       190        200        210        220        230        240 
PLITASILAK KLAEGLDALV MDVKVGSGAL MPTLAGSEAL AQAIVGVANG AGCRTIALLT 

       250        260        270        280        290        300 
DMNQVLASSA GNALEVREAV RFLTNDERNP RLFEVTMALC SEMLMIAGLA HSEDAARTAL 

       310        320        330        340        350        360 
VRALDSGEAA ERFGRMVAVQ GGPADFVQRY DLYLPVATLS KPVFPAGEGY IRSMDTRALG 

       370        380        390        400        410        420 
MTVVALGGGR QRARDAIDYS VGLTEMARLG DYVDANTPLA VVHAASEESW ARAAEAVRAA 

       430        440 
IQLGDVAPQA LPVVYRRITA AAD 

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008232 Genomic DNA. Translation: BAE73670.1.
RefSeqYP_454075.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NW05.
SMRQ2NW05. Positions 1-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING343509.SG0395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE73670; BAE73670; SG0395.
GeneID3867564.
KEGGsgl:SG0395.
PATRIC23647421. VBISodGlo61428_1034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
KOK00758.
OMADVWRRMI.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-420-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_SODGM
AccessionPrimary (citable) accession number: Q2NW05
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways