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Q2NVX5

- PDXA_SODGM

UniProt

Q2NVX5 - PDXA_SODGM

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Metal bindingi166 – 1661Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi211 – 2111Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi266 – 2661Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei274 – 2741SubstrateUniRule annotation
    Binding sitei283 – 2831SubstrateUniRule annotation
    Binding sitei292 – 2921SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-450-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:SG0425
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3303304-hydroxythreonine-4-phosphate dehydrogenasePRO_1000061034Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi343509.SG0425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NVX5.
    SMRiQ2NVX5. Positions 1-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    KOiK00097.
    OMAiIMANEMA.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2NVX5-1 [UniParc]FASTAAdd to Basket

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    MGSNQRIVIT PGEPAGIGPD LVAALAQQAW PVELVICADP ALLTARAQQL    50
    GLPLRLHSYR PEQPATPRPA GELTVLAIDT PAPVAAGELN VANSHYVVET 100
    LARACDSCLN GEFAALLTGP VHKGVINDGG LPFSGHTEYF AQRSGRERVV 150
    MMLATESLRV ALATTHLPLL AVPGAVTRQS LDEVITILVH DLQQQFGIAQ 200
    PCIYVCGLNP HAGEGGHMGR EEIEVITPAL DTLRAKGYNL VGPLPADTLF 250
    QPKYLQQADA VLAMYHDQGL PVLKYQGFGR AVNITLGLPF IRTSVDHGTA 300
    LELAGSGQAE AGSIKTALNI AIDMIKHRNE 330
    Length:330
    Mass (Da):35,035
    Last modified:February 7, 2006 - v1
    Checksum:i940A4955DB83CDF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE73700.1.
    RefSeqiWP_011410288.1. NC_007712.1.
    YP_454105.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE73700; BAE73700; SG0425.
    GeneIDi3867536.
    KEGGisgl:SG0425.
    PATRICi23647543. VBISodGlo61428_1095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE73700.1 .
    RefSeqi WP_011410288.1. NC_007712.1.
    YP_454105.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NVX5.
    SMRi Q2NVX5. Positions 1-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG0425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE73700 ; BAE73700 ; SG0425 .
    GeneIDi 3867536.
    KEGGi sgl:SG0425.
    PATRICi 23647543. VBISodGlo61428_1095.

    Phylogenomic databases

    eggNOGi COG1995.
    KOi K00097.
    OMAi IMANEMA.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci SGLO343509:GJJC-450-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiPDXA_SODGM
    AccessioniPrimary (citable) accession number: Q2NVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3