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Q2NUU7

- SYL_SODGM

UniProt

Q2NUU7 - SYL_SODGM

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Protein
Leucine--tRNA ligase
Gene
leuS, SG0803
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-838-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SG0803
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotation
PRO_1000009435Add
BLAST

Proteomic databases

PRIDEiQ2NUU7.

Interactioni

Protein-protein interaction databases

STRINGi343509.SG0803.

Structurei

3D structure databases

ProteinModelPortaliQ2NUU7.
SMRiQ2NUU7. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiYAANYIL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NUU7-1 [UniParc]FASTAAdd to Basket

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MQELYRPEEI ESTVQQHWHE NDTFKVTEDP CKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VIARYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
TYANIDYMKN QLKLLGFGYD WSREVTTCRP DYYRWEQWFF TRLYEKGLVY 150
KKTSAVNWCP QDQTVLANEQ VIDGCCWRCD TKVERKEIPQ WFVKITAYAD 200
QLLYDLDKLE SWPEQVKTMQ RNWIGRSEGV EITFQVADSE ETLTVYTTRP 250
DTFMGTTYVA VAAGHPLSLQ AAASNPALAD FIQECRTTKV AEADMATMEK 300
KGMATGLHAV HPLTGEMLPV WVANFVLMDY GTGAVMAVPG HDQRDFEFAR 350
KYDLPVKPVI RNADGSEPDL SAQAMTEKGV LFNSGEFDGL DFQAGFNAIA 400
DALVAQGVGE RKVNYRLRDW GVSRQRYWGA PIPMMTLEDG TVVPTPEDQL 450
PVVLPEDVVM DGISSPLKAD PDWAKTTYNG QPALRETDTF DTFMESSWYY 500
ARYTCPDYDR GMLDPAAANY WLPVDQYIGG IEHAIMHLMY FRFYHKLLRD 550
AGLVTSDEPA KRLLCQGMVL ADAFYYLTSS GERVWVSPLE VSVERDEKGR 600
IVKSTDASGR ELVYAGMSKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS 650
PAEMTLEWQE SGVEGANRFL KRVWKLAYEH PQQGPVGALD IDALNDEQKA 700
LRREVHKTIA KVTDDIGRRQ TFNTAIAAIM ELMNKLARAP QQTGQDRALL 750
QEALVAVVRM LYPFTPHACF TLWRALGGEG DIDNAPWPVA DEAAMVEDAK 800
LVVIQVNGKL RGRITVPADA DEALVCERAS QEHLVAKHLE GTTVRKVIYV 850
PGKLLNLVVG 860
Length:860
Mass (Da):97,024
Last modified:February 7, 2006 - v1
Checksum:iEA88CF33C5BFD2A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74078.1.
RefSeqiWP_011410666.1. NC_007712.1.
YP_454483.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74078; BAE74078; SG0803.
GeneIDi3868486.
KEGGisgl:SG0803.
PATRICi23649194. VBISodGlo61428_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74078.1 .
RefSeqi WP_011410666.1. NC_007712.1.
YP_454483.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NUU7.
SMRi Q2NUU7. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG0803.

Proteomic databases

PRIDEi Q2NUU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE74078 ; BAE74078 ; SG0803 .
GeneIDi 3868486.
KEGGi sgl:SG0803.
PATRICi 23649194. VBISodGlo61428_1912.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi YAANYIL.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SGLO343509:GJJC-838-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiSYL_SODGM
AccessioniPrimary (citable) accession number: Q2NUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi