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Q2NUU7

- SYL_SODGM

UniProt

Q2NUU7 - SYL_SODGM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-838-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SG0803
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligasePRO_1000009435Add
BLAST

Proteomic databases

PRIDEiQ2NUU7.

Interactioni

Protein-protein interaction databases

STRINGi343509.SG0803.

Structurei

3D structure databases

ProteinModelPortaliQ2NUU7.
SMRiQ2NUU7. Positions 228-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiYAANYIL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NUU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQELYRPEEI ESTVQQHWHE NDTFKVTEDP CKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VIARYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW
110 120 130 140 150
TYANIDYMKN QLKLLGFGYD WSREVTTCRP DYYRWEQWFF TRLYEKGLVY
160 170 180 190 200
KKTSAVNWCP QDQTVLANEQ VIDGCCWRCD TKVERKEIPQ WFVKITAYAD
210 220 230 240 250
QLLYDLDKLE SWPEQVKTMQ RNWIGRSEGV EITFQVADSE ETLTVYTTRP
260 270 280 290 300
DTFMGTTYVA VAAGHPLSLQ AAASNPALAD FIQECRTTKV AEADMATMEK
310 320 330 340 350
KGMATGLHAV HPLTGEMLPV WVANFVLMDY GTGAVMAVPG HDQRDFEFAR
360 370 380 390 400
KYDLPVKPVI RNADGSEPDL SAQAMTEKGV LFNSGEFDGL DFQAGFNAIA
410 420 430 440 450
DALVAQGVGE RKVNYRLRDW GVSRQRYWGA PIPMMTLEDG TVVPTPEDQL
460 470 480 490 500
PVVLPEDVVM DGISSPLKAD PDWAKTTYNG QPALRETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPDYDR GMLDPAAANY WLPVDQYIGG IEHAIMHLMY FRFYHKLLRD
560 570 580 590 600
AGLVTSDEPA KRLLCQGMVL ADAFYYLTSS GERVWVSPLE VSVERDEKGR
610 620 630 640 650
IVKSTDASGR ELVYAGMSKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGANRFL KRVWKLAYEH PQQGPVGALD IDALNDEQKA
710 720 730 740 750
LRREVHKTIA KVTDDIGRRQ TFNTAIAAIM ELMNKLARAP QQTGQDRALL
760 770 780 790 800
QEALVAVVRM LYPFTPHACF TLWRALGGEG DIDNAPWPVA DEAAMVEDAK
810 820 830 840 850
LVVIQVNGKL RGRITVPADA DEALVCERAS QEHLVAKHLE GTTVRKVIYV
860
PGKLLNLVVG
Length:860
Mass (Da):97,024
Last modified:February 7, 2006 - v1
Checksum:iEA88CF33C5BFD2A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74078.1.
RefSeqiYP_454483.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74078; BAE74078; SG0803.
GeneIDi3868486.
KEGGisgl:SG0803.
PATRICi23649194. VBISodGlo61428_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74078.1 .
RefSeqi YP_454483.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NUU7.
SMRi Q2NUU7. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG0803.

Proteomic databases

PRIDEi Q2NUU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE74078 ; BAE74078 ; SG0803 .
GeneIDi 3868486.
KEGGi sgl:SG0803.
PATRICi 23649194. VBISodGlo61428_1912.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi YAANYIL.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SGLO343509:GJJC-838-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiSYL_SODGM
AccessioniPrimary (citable) accession number: Q2NUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3