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Q2NUK1 (DDL_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:SG0899
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341175

Regions

Domain150 – 353204ATP-grasp
Nucleotide binding180 – 23556ATP By similarity

Sites

Metal binding3071Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 2 By similarity
Metal binding3221Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NUK1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: EDADEF14E288F191

FASTA36639,016
        10         20         30         40         50         60 
MEPRESGKQR VAVLFGGQST EHEVSLRSSM NVIRAIDRQK YDLTLIGVDK HGRWTLCDEQ 

        70         80         90        100        110        120 
DYLLNADNPA AIRLAPARCY LAVVPGQSGA QLIDAANGQP FPSIDVAFSV LHGASGEDGS 

       130        140        150        160        170        180 
VQGLLRVLNI PYAGPDVLGS AVCMDKDMTK RVLRDAGVPV TPSVTLLRTG DAAPDVDAII 

       190        200        210        220        230        240 
GQLGLPLFIK PASQGSSVGV SKVTDRAGFA AALALAFRYD AKVLVEQGIS GREIETAVLG 

       250        260        270        280        290        300 
NDSPEVSVCG EILANDEFYA YDTKYLKGAQ AGLVIPAALP APIADALRQM AREAYLALGC 

       310        320        330        340        350        360 
SVMARVDFFL TDQGQILLNE VNTLPGFTSI SMYPKLWEAS GLDYPALVDR LIVLARASAR 


QNAEIR 

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008232 Genomic DNA. Translation: BAE74174.1.
RefSeqYP_454579.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NUK1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING343509.SG0899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE74174; BAE74174; SG0899.
GeneID3868347.
KEGGsgl:SG0899.
PATRIC23649464. VBISodGlo61428_2040.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-941-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_SODGM
AccessionPrimary (citable) accession number: Q2NUK1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways